Abstract
Organic nitrates are widely used in the management of patients with angina pectoris, and with increasing frequency for load reduction in patients with impaired left-ventricular function [1, 2]. The usefulness of isosorbide dinitrate (ISDN) was initially called in question because of extensive first-pass metabolism in the liver; ISDN is rapidly metabolized to isosorbide-2-mononitrate (IS-2-MN) and isosorbide-5-mononitrate (IS-5-MN) [3].
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References
Franciosa JA, Nordstrom LA, Cohn JN (1978) Nitrate therapy for congestive heart failure. JAMA 240:433
Franciosa JA, Blank RL, Cohn JN (1978) Nitrate effects on cardiac output and left ventricular outflow resistance in chronic congestive heart failure. Am J Med 64:207
Dietmann K, Sponer G, Voss E (1981) Pharmacodynamik, Pharmakokinetik und Metabolismus der Nitrate des Isosorbids am wachen Hund. Med Welt 32/14a:481
Baxter RH, Tait CM, McGuinness JB (1977) Vasodilator therapy in acute myocardial infarction. Br Heart J 39:1067
Biamino G, Oeff M, Anderson D, Lichey H J, Prokein E, Arntz R, Von Leitner ER, Schröder R (1982) Hemodynamic effects of isosorbide-5-mononitrate in patients with coronary artery disease at rest and under exercise. Med Dok, Boehringer, Mannheim
Chatterjee K, Parmley WW (1977) Vasodilator treatment for acute and chronic heart failure. Br Heart J 39:706
Abshagen U, Spörl-Radun S (1981) First data on effects and pharmacokinetics of isosorbide-5-mononitrate in normal man. Eur J Clin Pharmacol 19:423
Wendt RL (1972) Systemic and coronary vascular effects of the 2- and 5-mononitrate esters of isosorbide. J Pharmacol Exp Ther 180:732
Überbacher HJ, Glocke M, Abshagen U (1983) Langzeitverträglichkeit und koronartherapeu-tische Wirksamkeit von Isosorbid-5-mononitrat. Offene Multicenter-Studie unter Praxisbedingungen mit ISMO 20. Münch Med Wochenschr 125:76
Bödigheimer K, Nowak FG, Delius W (1981) Vergleichende invasive Untersuchung über die Wirkung von Isosorbid-5-mononitrat und Isosorbid-dinitrat bei chronischer Herzinsuffizienz. Med Welt 32:543
Überbacher HJ, Steinorth G, Glocke M, Abshagen U (1983) An open, long-term multi-centre study of the anti-anginal efficacy and safety of isosorbide-5-mononitrate at low doses in patients with coronary heart disease. Pharmacotherapeutica 3:331
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Tronconi, L., Raisaro, A., Recusani, F., Gazzaniga, P., Lanzarini, L. (1985). Efficacy of IS-5-MN (ISMO 20) in Patients with Coronary Artery Disease and Impaired Left-Ventricular Function. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_37
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DOI: https://doi.org/10.1007/978-3-642-70234-1_37
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