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Mononitrates pp 130–146Cite as

Clinical Relevance of Nitrate Tolerance

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Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

Abstract

Nitrates have been used for more than 100 years to curtail angina pectoris attacks [15, 54]. There can be no doubt whatsoever about their positive effects in the treatment of acute episodes. However, during the past few years, there has been increasing controversy in discussions concerning the maintenance of nitrate effects when prescribed as long-term therapy. While some groups have shown evidence of either a weakening, or indeed a loss, of efficacy [6, 38, 69, 83], others have not been able to confirm these findings [5, 20, 21, 48, 57, 72, 73, 86]. In summarizing the studies published to date on this subject it is intended here, to present a balanced picture, in order to draw practical conclusions from the comparison of arguments for and against nitrate tolerance.

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  1. S. Silber
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Editors and Affiliations

  1. Cardiovascular Division, University of Minnesota, Box 508, Mayo Memorial Building, 420 Delaware Street S. E., Minneapolis, 55455, MN, USA

    Jay N. Cohn Prof., M. D.

  2. Product Development, Boehringer Mannheim GmbH, Postfach 31 01 20, D-6800, Mannheim 31, Federal Republic of Germany

    Reiner Rittinghausen M. D.

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Silber, S. (1985). Clinical Relevance of Nitrate Tolerance. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_18

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  • DOI: https://doi.org/10.1007/978-3-642-70234-1_18

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