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Tolerance and Rebound Phenomena in Nitrate Therapy

  • Conference paper
Mononitrates

Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

Abstract

The phenomenon of tolerance to nitrates has been known for a long time; the first report on the subject dates back to 1888 [35, 1]. Blasini and coworkers, a few years ago, initiated controversial discussion about the clinical importance of nitrate tolerance [1–3, 7, 13, 22, 27, 31]. Several studies, using different nitrate formulations and different dosages and investigating different parameters have yielded controversial results [5–9, 11, 13–21, 24–27, 30–34, 38–41, 43, 44]. The present study questions whether tolerance depends on dosage and formulation and which parameters best prove clinically relevant tolerance to nitrates.

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Authors
  1. H. Ohlmeier
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  2. H. M. Mertens
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  3. H. Mannebach
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  4. U. Gleichmann
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Editor information

Editors and Affiliations

  1. Cardiovascular Division, University of Minnesota, Box 508, Mayo Memorial Building, 420 Delaware Street S. E., Minneapolis, 55455, MN, USA

    Jay N. Cohn Prof., M. D.

  2. Product Development, Boehringer Mannheim GmbH, Postfach 31 01 20, D-6800, Mannheim 31, Federal Republic of Germany

    Reiner Rittinghausen M. D.

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© 1985 Springer-Verlag Berlin Heidelberg

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Ohlmeier, H., Mertens, H.M., Mannebach, H., Gleichmann, U. (1985). Tolerance and Rebound Phenomena in Nitrate Therapy. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_16

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  • DOI: https://doi.org/10.1007/978-3-642-70234-1_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15107-4

  • Online ISBN: 978-3-642-70234-1

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