Kinetics of IS-5-MN and Its Glucuronide in Patients with Renal Failure
Patients with renal failure are sometimes suffering from coronary heart disease and deserve antianginal therapy. Although from kinetic studies with isosorbide-5-mono-nitrate (IS-5-MN) it is known that only a minimal amount of the unchanged drug is excreted via the kidneys (Abshagen et al. 1981) and single-dose studies in renal patients exhibited no difference of the kinetic behavior (Bogaert et al. 1981) it was of interest to see whether this could also be confirmed after multiple administration of the drug (ISMO 20) to patients with severe renal failure. Furthermore, we were interested in the kinetic behavior of the two primary metabolites of IS-5-MN in this group of patients, isosorbide (IS) and isosorbide-5-mononitrate-2-glucuronide (IS-5-MN-2-glu). The results of this study were compared with those of a metabolism study of IS-5-MN in healthy volunteers.
KeywordsRenal Clearance Volunteer Group Severe Renal Failure Fitted Curf Renal Patient
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