Abstract
Thyroid function in uremia has not been studied as extensively in children as it has been in adults. The data available point to a low T3 and T4 syndrome, but it is not clear whether these patients are hypothyroid or not [1–5]. In addition, little is known about free hormone concentration with respect to the various dialytic modalities for this age group of patients. This work was designed to study thyroid function in children undergoing CAPD. The data presented indicate that CAPD does not correct the low T3 and T4 syndrome. In addition, stunted TSH response to TRH is present.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Czernichow P, Dauzet MC, Broyer M, Rappaport R (1976) Abnormal TSH, PRL and GH response to TSH releasing factor in chronic uremia. J Clin Endocrinol Metab 43:630
Wassner JJ, Buckingham BA, Kershar AJ, Malekzadeh MH, Pennisi AJ, Fine RN (1977) Thyroid function in children with chronic renal failure. Nephron 19:236
Chan JCM, Hung W (1978) Hemodialysis and thyroid function in children. J Dial Transplant 2:387
Waters W, Bulla M, Tekook A (1982) Thyroid function in children on regular hemodialysis. In: Bulla M (ed) Renal insufficiency in children. Springer, Berlin Heidelberg New York, p 129
De Santo NG, Fine RN, Carella C, Leumann E, Amato G, Fine S, Nuzzi F, Capasso G, Capodicasa G, Lama G, Scoppa F, and Giordano C. Thyroidal status in uremic children. Kidney Int (in press)
Giordano C, Carella C, De Santo NG, Mioli V, Bazzato G, Amato G, Tarchini A, Coli U, Landini S (1982) Hormonal status of patients on CAPD and HD. In: La Greca G (ed) Proceedings 1st international course on peritoneal dialysis. Wichtig, Milan, p 330
Giordano C, De Santo NG, Carella C, Mioli V, Bazzato G, Di Leo Va, Amato G, Tarchini A, Coli V, Landini S (1982) Thyroid status in uremia, effects of hemodialysis and CAPD. Int JArtif Organs 5:394
Giordano C, De Santo NG, Carella C, Mioli V, Bazzato G, Amato G, Tarchini A, Coli V, Capasso G, Landini V, Capodicasa G, Nuzzi F, Esposito A. Thyroidal function during hemodialysis and CAPD. Proceedings 4th ISAO Conference. Artif Organs (in press)
Giordano C, De Santo NG, Carella C, Mioli V, Bazzato G, Amato G, Di Leo VA, Tarchini G, Coli U, Capodicasa G, Landini G, Nuzzi F, De Simon V, Esposito A (1984) TSH response to TRH in hemodialysis and CAPD patients. Int J Artif Organs 7:7
Giordano C, De Santo NG, Carella C, Capodicasa G, Amato G, Nuzzi F, Mioli V, Bazzato G, De Simone V, Tarchini A, Landini A, Coli U, Bordoni V, Mottola G, Capuano F (1984) Thyroid status and nephron loss. A study in patients with chronic renal failure, end stage renal disease and/or on hemodialysis. Int J Artif Organs 7:119
Ramirez G, Jubitz W, Gutch CF, Bloomer HA, Siegler R, Kolff WJ (1973) Thyroid abnormalities in renal failure. A study on 53 patients on chronic hemodialysis. Ann Intern Med 79:504
Carter JN, Eastman CJ, Corcoran P, Lazarus L (1974) Effects of severe illness on thyroid function. Lancet 2:971
Spector DA, Davis JP, Helderman JH, Bell B, Utiger RD (1976) Thyroid function and metabolic state in chronic renal failure. Ann Intern Med 85:274
Savdie E, Stewart JH, Mahony JF, Hayer JM, Lazarus L, Simons LA (1978) Circulating thyroid hormone levels and adequacy of dialysis. Clin Nephrol 9:68
Weissel M, Stummval HK, Wolf A, Fritsche H (1977) Thyroid hormone in chronic renal failure. Ann Intern Med 86:644
Kalk WJ, Morley JE, Gold GH, Meyers A (1980) Thyroid function tests in patients on regular hemodialysis. Nephron 25:173
Farrington K, Boss AMB, Varghese Z, Kingstone D, Baillod RA, Moorhead JF (1980) Thyroid function tests in dialyzed patients. Dial Transplant 9:846
Czekalski S, Malczeva B, Sobieszczyk S, Kozak W, Eder M, Grycynska M, Backzyk K, Kosowicz J (1981) Comparison of some circulating pituitary thyroid and gonadal hormone levels in non dialyzed and dialyzed males with chronic renal failure. Dial Transplant 10:438
Nogimori T (1981) A Clinical study on thyroid hormone secretion and metabolism in patients with chronic renal failure on hemodialysis. Folia Endocrinol (Jpn) 57:903
Gavin LA, McMahon FA, Castle JN, Cavalier RC (1970) Alternions in serum thyroid hormones and thyroxin binding globulin in patients with nephrosis. J Clin Endocrinol Metab 49:63
Kaptein EM, MacIntyre SS, Weiner SM, Spencer CA, Nicoloff JT (1981) Free thyroxine estimates in non thyroidal illness. Comparison of eight methods. J Clin Endocrinol Metab 52:1073
Penny R, Spencer CA, Frasier DS, Nicoloff JT (1983) Thyroid stimulating hormone and thyroglobulin levels decrease with chronological age in children and adolescents. J Clin Endocrinol Metab 56:177
De Santo NG, Carella C, Fine RN, Leumann E, Fine S, Amato G, Capodicasa G, Nuzzi F, Capasso G, Lama G, Scoppa F, De Simone V, Giordano C (1984) Data presented at Bari Seminars in nephrology 29–31 March
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
De Santo, N.G. et al. (1985). Thyroid Function in Children on CAPD. In: Fine, R.N., Schärer, K., Mehls, O. (eds) CAPD in Children. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70213-6_16
Download citation
DOI: https://doi.org/10.1007/978-3-642-70213-6_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70215-0
Online ISBN: 978-3-642-70213-6
eBook Packages: Springer Book Archive