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Calmodulin Gene Structure and Expression

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Calcium and Cell Physiology

Abstract

Calmodulin (CaM) is now recognized as a major intracellular Ca2+ receptor that function in a regulatory capacity for a diverse array of enzymatic reactions and biochemical pathways. The pleiotropic nature of CaM-regulated events has sparked intensive research efforts concerning the biology, structure and mechanism of action of CaM (Means et al. 1982; Klee and Vanaman 1982). This protein seems to be constitutively expressed in a number of hormonally regulated systems (Means et al. 1982; Means and Dedman 1980) but is found in elevated concentrations in virally transformed cells (Watterson et al. 1976; Chafouleas et al. 1981) and is acutely regulated at the Gl/S boundary of the cell cycle (Chafouleas et al. 1982; Chafouleas et al. 1984). As a prelude to understanding the molecular mechanism that control these changes in CaM, we have initiated a series of studies employing recombinant DNA technology to isolate and sequence the nucleic acids involved in CaM metabolism.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Baylor College of Medicine, Houston, TX, 77030, USA

    J. A. Putkey

Authors
  1. A. R. Means
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  2. L. Lagace
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  3. R. C. M. Simmen
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  4. J. A. Putkey
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Editor information

Editors and Affiliations

  1. Gödecke Research Institute, Gödecke AG, Mooswaldallee 1–9, 7800, Freiburg, Germany

    Dieter Marmé

  2. Institute of Biology III, University of Freiburg, Schänzlestr. 1, 7800, Freiburg, Germany

    Dieter Marmé

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© 1985 Springer-Verlag, Berlin Heidelberg

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Means, A.R., Lagace, L., Simmen, R.C.M., Putkey, J.A. (1985). Calmodulin Gene Structure and Expression. In: Marmé, D. (eds) Calcium and Cell Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70070-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-70070-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70072-9

  • Online ISBN: 978-3-642-70070-5

  • eBook Packages: Springer Book Archive

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