Calcium and Cell Physiology pp 311-327
Calcium Regulation of Histamine Secretion from Mast Cells
The mast cell is centrally involved in the immunopathology of acute allergic and inflammatory disease (Pepys and Edwards 1979). These cells are widely distributed in the human body, but are found at the highest concentrations in those areas which come into direct contact with foreign substances, namely in association with blood vessels and nerves in the loose connective tissue of the bronchi, conjunctiva, gut, ear, nose, throat and skin. As such, they are uniquely placed to participate in a variety of allergic disorders and have been incriminated in the aetiology of asthma, rhinitis, conjunctivitis and inflammatory diseases of the gut and skin (Pepys and Edwards 1979).
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