Abstract
The mast cell is centrally involved in the immunopathology of acute allergic and inflammatory disease (Pepys and Edwards 1979). These cells are widely distributed in the human body, but are found at the highest concentrations in those areas which come into direct contact with foreign substances, namely in association with blood vessels and nerves in the loose connective tissue of the bronchi, conjunctiva, gut, ear, nose, throat and skin. As such, they are uniquely placed to participate in a variety of allergic disorders and have been incriminated in the aetiology of asthma, rhinitis, conjunctivitis and inflammatory diseases of the gut and skin (Pepys and Edwards 1979).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alm PE (1983) Cyclic AMP levels during stimulation and inhibition of histamine release from rat mast cells by the calmodulin inhibitor trifluoperazine. Int Arch Allergy Appl Immunol 71: 103–111
Ammellal M, Landry Y (1983) Lanthanides are transported by ionophore A23187 and mimic calcium in the histamine secretion process. Br J Pharmacol 80: 365–370
Axelrod J, Hirata F (1982) Phospholipid methylation and the receptor-induced release of histamine from cells. Trends Pharmacol Sci 3: 156–158
Bennet JP, Cockcroft S, Gomperts BD (1979) Ionomycin stimulates mast cell histamine secretion by forming a lipid-soluble calcium complex. Nature (Lond) 282:851–853
Bennet JP, Cockcroft S, Gomperts BD (1981) Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range. Biochem J 317: 335–345
Beynon RC, Church MK, Holgate ST (1983) Inhibitors of transmethylation decrease histamine release from rat peritoneal and human dispersed lung mast cells. Br J Pharmacol 79: 242 P
Brostrom CO, Wolff DJ (1981) Properties and functions of calmodulin. Biochem Pharmacol 30:1395–1405
Burt DS, Stanworth DR (1983) Changes in cellular levels of cyclic AMP in rat mast cells during secretion of histamine induced by immunoglobulin E decapeptide and ACTH (1–24) peptide. Comparison with immunological and ionophore triggers. Biochim Biophys Acta 762: 458–465
Cheung WY (1980a) Calmodulin plays a pivotal role in cellular regulation. Science (Wash DC) 207: 19–27
Cheung WY (ed) (1980b) Calcium and cell function, vol I. Calmodulin. Academic, New York
Cochrane DE, Distel DI (1982) Association of 45 calcium with rat mast cells stimulated by 48/80: effects of inactivation, calcium and metabolic inhibition. J Physiol (Lond) 330: 413–427
Cockcroft S (1981) Does phosphatidylinositol breakdown control the Ca’+-gating mechanism? Trends Pharmacol Sci 2: 340–342
Cockcroft S, Gomperts BD (1979) Evidence for a role of phosphatidylinositol turnover in stimulus-secretion coupling. Biochem J 178: 681–687
Cockcroft S, Gomperts BD (1980) The ATP4- receptor of rat mast cells. Biochem J 188: 789–798
Crews FT, Morita Y, Hirata F, Axelrod J, Siraganian RP (1980) Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemic basophils. Biochem Biophys Res Commun 93: 42–49
Crews FT, Morita Y, McGivney A, Hirata F, Siraganian RP, Axelrod J (1981) IgE-mediated histamine release in rat basophilic leukemia cells: receptor activation, phospholipid methylation, Cat+ flux and release of arachidonic acid. Arch Biochem Biophys 212: 561–571
Cumella J, Middleton E, Drzewiecki G (1983) Effect of calmodulin (CaM) antagonists on basophil histamine release (HR). J Allergy Clin Immunol 71: 94
Dahlquist R (1974) Relationship of uptake of sodium and 45 calcium to ATP-induced histamine release from rat mast cells. Acta Pharmacol Toxicol 35: 11–22
Douglas WW, Kagayama M (1977) Calcium and stimulus-secretion coupling in the mast cell: stimu- lant and inhibitory effects of calcium-rich media on exocytosis. J Physiol (Lond) 270: 691–703
Douglas WW, Nemeth EF (1982) On the calcium receptor activating exocytosis: inhibitory effects of calmodulin-interacting drugs on rat mast cells. J Physiol (Lond) 323: 229–244
Ennis M, Truneh A, White JR, Pearce FL (1980) Calcium pools involved in histamine release from rat mast cells. Int Arch Allergy Appl Immunol 62: 467–471
Ennis M, Truneh A, Pearce FL (1981) Lectin-induced histamine secretion from isolated rat and guinea pig mast cells. Biochem Pharmacol 30: 2179–2181
Foreman JC, Mongar JL (1973) The action of lanthanum and manganese on anaphylactic histamine secretion. Br J Pharmacol 48: 527–537
Foreman JC, Mongar JL, Gomperts BD (1973) Calcium ionophores and movement of calcium ions following the physiological stimulus to a secretory process. Nature (Lond) 245: 249–251
Foreman JC, Garland LG, Mongar JL (1976) The role of calcium in secretory processes: model studies in mast cells. In: Duncan CJ (ed) Calcium in biological systems. Cambridge University Press, Cambridge, pp 193–218
Foreman IC, Hallett MB, Mongar JL (1977) The relationship between histamine secretion and 45calcium uptake by mast cells. J Physiol (Lond) 271: 193–214
Gil DW, Brown SA, Seeholzer SH, Wildey GM (1983) Phosphatidylinositol turnover and cellular function. Life Sci 32: 2043–2046
Gillespie E, Lichtenstein LM (1972) Histamine release from human leukocytes: studies with deuterium oxide, colchicine, and cytochalasin B. J Clin Invest 51: 2941–2947
Gillespie E, Lichtenstein LM (1975) Histamine release from human leukocytes: relationships between cyclic nucleotide, calcium, and antigen concentrations. J Immunol 115: 1572–1576
Gomperts BD, Baldwin JM, Micklem KJ (1983) Rat mast cells permeabilized with Sendai virus secrete histamine in response to Ca2+ buffered in the micromolar range. Biochem J 210: 737–745
Grosman N, Diamant B (1974) Studies on the role of calcium in anaphylactic histamine release from isolated rat mast cells. Acta Pharmacol Toxicol 35: 284–292
Grosman N, Diamant B (1978) Binding of 45 calcium to isolated rat mast cells in connection with histamine release. Agents Actions 8: 338–346
Hirata F, Axelrod J (1980) Phospholipid methylation and biological signal transmission. Science (Wash DC) 209: 1082–1090
Hirata F, Axelrod J, Crews FT (1979) Concanavalin A stimulates methylation and phosphatidylserine decarboxylation in rat mast cells. Proc Natl Acad Sci USA 76: 4813–4816
Holgate ST, Lewis RA, Austen KF (1980a) The role of cyclic nucleotides in mast cell activation and secretion. In: Fougereau M, Dausset J (eds) Immunology 80. Academic, London, pp 846–859
Holgate ST, Lewis RA, Austen KF (1980b) Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine-and ribose-modified adenosine analogs. Proc Natl Acad Sci USA 77: 6800–6804
Holgate ST, Lewis RA, Austen KF (1980c) 3,5-Cyclic adenosine monophosphatedependent protein kinase of the rat serosal mast cell and its immunologic activation. J Immunol 124:2093–2099
Holgate ST, Lewis RA, Maguire JF, Roberts LJ, Oates JA, Austen KF (1980d) Effects of prostaglandin DZ on rat serosal mast cells: discordance between immunologic mediator release and cyclic AMP levels. J Immunol 125: 1367–1373
Hughes PI, Holgate ST, Roath S, Church MK (1983) The relationship between cyclic AMP changes and histamine release from basophil-rich human leucocytes. Biochem Pharmacol 17: 2557–2563
Ishizaka T (1982) Biochemical analysis of triggering signals induced by bridging of IgE receptors. Fed Proc Fed Am Soc Exp Biol 14: 17–21
Ishizaka T, Hirata F, Ishizaka K, Axelrod J (1980) Stimulation of phospholipid methylation, Ca2+ influx and histamine release by bridging of IgE receptors on rat mast cells. Proc Natl Acad Sci USA 77: 1903–1906
Ishizaka T, Hirata F, Ishizaka K, Axelrod J (1981a) Transmission and regulation of triggering signals induced by bridging of IgE receptors on rat mast cells. In: Becker EL, Simon AS, Austen KF (eds) Biochemistry of the acute allergic reactions. Liss, New York, pp 213–227
Ishizaka T, Hirata F, Sterk AR, Ishizaka K, Axelrod JA (1981b) Bridging of IgE receptors activates phospholipid methylation and adenylate cyclase in mast cell plasma membranes. Proc Natl Acad Sci USA 78:6812–6816
Ishizaka T, Conrad DH, Schulman ES, Sterk AR, Ishizaka K (1983) Biochemical analysis of initial triggering events of IgE-mediated histamine release from human lung mast cells. J Immunol 130: 2357–2362
Kaliner M (1977) Human lung tissue and anaphylaxis. Evidence that cyclic nucleotides modulate the immunologic release of mediators through effects on microtubular assembly. J Clin Invest 60: 951–959
Kaliner M, Austen KF (1974) Cyclic nucleotides and modulation of effector systems of inflammation. Biochem Pharmacol 23: 763–771
Kano T, Cochrane DE, Douglas WW (1973) Exocytosis (secretory granule extrusion) induced by injection of calcium into mast cells. Can J Physiol Pharmacol 51: 1001–1004
Kazimierczak W, Diamant B (1978) Mechanisms of histamine release in anaphylactic and anaphylactoid reactions. Progr Allergy 24: 295–365
Kennerly DA, Sullivan TJ, Parker CW (1979) Activation of phospholipid metabolism during mediator release from stimulated mast cells. J Immunol 122: 152–159
Klee CB, Crouch TH, Richman PG (1980) Calmodulin. Annu Rev Biochem 49: 489–515
König W, Pfeiffer F, Kunau HW (1981) Effect of arachidonic acid metabolites on the histamine release from human basophils and rat mast cells. Int Arch Allergy Appl Immunol 66 (Suppl 1): 149–151
Lagunoff D, Martin TW, Read G (1983) Agents that release histamine from mast cells. Annu Rev Pharmacol Toxicol 23: 331–351
Lewis RA, Austen KF (1981) Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent components. Nature (Lond) 293: 103–108
Lewis RA, Holgate ST, Roberts LJ, Maguire JF, Oates JA, Austen KF (1979) Effects of indomethacin on cyclic nucleotide levels and histamine release from rat serosal mast cells. J Immunol 123: 1663–1668
McGivney A, Crews FT, Hirata F, Axelrod J, Siraganian RP (1981a) Rat basophilic leukemia cell lines defective in phospholipid methyltransferase enzymes, Ca2+ influx and histamine release: reconstitution by hybridization. Proc Natl Acad Sci USA 78: 6176–6180
McGivney A, Morita Y, Crews FT, Hirata F, Axelrod J, Siraganian RP (1981b) Phospholipase activation in the IgE-mediated and Ca2+ ionophore A23187-induced release of histamine from rat basophil leukemia cells. Arch Biochem Biophys 212: 572–580
MacGlashan DW, Schleimer RP, Peters SP et al. (1983) Comparative studies of human basophils and mast cells. Fed Proc Fed Am Soc Exp Biol 42: 2504–2509
Magro AM (1982) Effect of inhibitors of arachidonic acid metabolism upon IgE and non-IgEmediated histamine release. Int J Immunopharmacol 4: 15–20
Marone G, Kagey-Sobotka A, Lichtenstein LM (1979) Effects of arachidonic acid and its metabolites on antigen-induced histamine release from human basophils in vitro. J Immunol 123: 1669–1677
Marone G, Kagey-Sobotka A, Lichtenstein LM (1981) Control mechanisms of histamine release from human basophils in vitro: the role of phospholipase A2 and of lipoxygenase metabolites. Int Arch Allergy Appl Immunol 66 (Suppl 1): 144–148
Marone G, Columbo M, Poto S, Bianco P, Torella G, Condorelli M (1983a) Possible role of calmodulin in human inflammatory reactions. Monogr Allergy 18: 290–299
Marone G, Columbo M, Poto S, Conorelli M (1983b) Modulation of histamine release from human basophils by calmodulin antagonists. J Allergy Clin Immunol 71: 94
Marquardt DL, Parker CW, Sullivan TJ (1978) Potentiation of mast cell mediator release by adenosine. J Immunol 120: 871–878
Means AR, Dedman JR (1980) Calmodulin — an intracellular calcium receptor. Nature (Lond) 285: 73–77
Means AR, Tash JS, Chafouleas JG (1982) Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. Physiol Rev 62: 1–38
Metcalfe DD, Kaliner M, Donlon MA (1981) The mast cell. CRC Crit Rev Immunol 3: 23–74
Michel RH (1983) Polyphosphoinositide breakdown as the initiating reaction in receptor stimulated inositol phospholipid metabolism. Life Sci 32: 2083–2085
Michell RH, Kirk CJ (1982) The unknown meaning of receptor-stimulated inositol lipid metabolism. Trends Pharmacol Sci 2: 140–141
Morita Y, Siraganian RP (1981) Inhibition of IgE-mediated histamine release from rat basophil leukemia cells and rat mast cells by inhibitors of transmethylation. J Immunol 127: 1339–1344
Morita Y, Chiang PK, Siraganian RP (1981) Effect of inhibitors of transmethylation on histamine release from human basophils. Biochem Pharmacol 30: 785–791
Nemeth EF, Douglas WW (1980) Differential inhibitory effects of the arachidonic acid analogue ETYA on rat mast cell exocytosis evoked by secretagogues utilizing cellular or extracellular calcium. Eur J Pharmacol 67: 439–450
Nemeth EF, Douglas WW (1982) Lipoxygenase inhibitors exert secretagogue-specific effects on mast cell exocytosis. Eur J Pharmacol 79: 315–318
Peachell PT, Pearce FL (1984) Some studies on the release of histamine from mast cells treated with polymyxin. Agents Actions 14: 379–385
Pearce FL (1982a) Calcium and histamine secretion from mast cells. Prog Med Chem 19: 59–109
Pearce FL (1982b) Functional heterogeneity of mast cells from different species and tissues. Klin Wochenschr 60: 954–957
Pearce FL (1983) Mast cell heterogeneity. Trends Pharmacol Sci 4: 165–167
Pearce FL (to be published 1984) Biochemical events involved in the release of anaphylactic mediators from mast cells. Asthma Rev
Pearce FL, Messis PD (1982) Phosphatidic acid induces histamine secretion from rat peritoneal mast cells. Int Arch Allergy Appl Immunol 68: 93–95
Pearce FL, White JR (1981) Effect of lanthanide ions on histamine secretion from rat peritoneal mast cells. Br J Pharmacol 72: 341–347
Pearce FL, White JR (1984) Calcium efflux and histamine secretion from rat peritoneal mast cells. Agents Actions 14: 392–396
Pearce FL, Ennis M, Truneh A, White JR (1981) Role of intra-and extracellular calcium in histamine release from rat peritoneal mast cells. Agents Actions 11: 51–54
Pearce FL, Barrett KE, White JR (1983) Histamine secretion from mast cells treated with chlortetracycline (aureomycin): a novel calcium ionophore. Agents Actions 13: 117–122
Pepys J, Edwards AM (eds) (1979) The mast cell: its role in health and disease. Pitman, Tunbridge Wells
Peters SP, Siegel MI, Kagey-Sobotka A, Lichtenstein LM (1981) Lipoxygenase products modulate histamine release in human basophils. Nature (Lond) 292: 455–457
Ranadive NS, Dhanani N (1980) Movement of calcium ions and release of histamine from rat mast cells. Int Arch Allergy Appl Immunol 61: 9–18
Ranadive NS, Lewis R (1982) Extracellular effect of calcium on compound 48/80 stimulated mast cells. Can J Biochem Cell Biol 61: 79–84
Samuelsson B (1983) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science (Wash DC) 220: 568–575
Schellenberg RR (1980) Enhanced phospholipid metabolism in rat mast cells stimulated to release histamine. Immunology 41: 123–129
Sieghart W, Theoharides TC, Alper SL, Douglas WW, Greengard P (1978) Calcium-dependent protein phosphorylation during secretion by exocytosis in the mast cell. Nature (Lond) 275: 329–331
Spataro AC, Bosmann HB (1976) Mechanism of action of disodium cromoglycate-mast cell calciumion influx after a histamine-releasing stimulus. Biochem Pharmacol 25: 505–510
Stenson WF, Parker CW, Sullivan TJ (1980) Augmentation of IgE-mediated release of histamine by 5-hydroxyeicosatetraenoic acid and 12-hydroxyeicosatetraenoic acid. Biochem Biophys Res Commun 96: 1045–1052
Sugiyama K (1971) Significance of ATP splitting activity of rat peritoneal mast cells in the histamine release induced by exogenous ATP. Jpn J Pharmacol 21: 531–539
Sullivan TJ, Parker CW (1979) Possible role of arachidonic acid and its metabolites in mediator release from rat mast cells. J Immunol 122: 431–436
Sullivan TJ, Parker KL, Eisen SA, Parker CW (1975) Modulation of cyclic AMP in purified rat mast cells. II. Studies on the relationship between intracellular cyclic AMP concentrations and histamine release. J Immunol 114: 1480–1485
Sullivan TJ, Parker KL, Kulczycki A, Parker CW (1976) Modulation of cylclic AMP in purified rat mast cells. III. Studies on the effects of concanavalin A and anti-IgE on cyclic AMP concentrations during histamine release. J Immunol 117: 713–716
Suzuki T, Ohishi K, Uchida M (1983) Effects of calmodulin inhibitor on histamine release from rat peritoneal mast cells induced by concanavalin A and ionophore A23187. Biochem Pharmacol 14: 273–275
Theoharides TC, Douglas WW (1978) Secretion in mast cells induced by calcium trapped within phospholipid vesicles. Science (Wash DC) 201: 1143–1145
Truneh A, Pearce FL (1981) Characteristics of and calcium requirements for histamine release from rat peritoneal mast cells treated with concanavalin A. Int Arch Allergy Appl Immunol 66: 68–75
Vincenzi FF (1981) The pharmacologcal implications of calmodulin. Trends Pharmacol Sci 2: 7–8
Weiss B, Prozialeck WC, Wallace TL (1982) Interaction of drugs with calmodulin. Biochemical, pharmacological and clinical implications. Biochem Pharmacol 31: 2217–2226
White JR, Pearce FL (1981) Role of membrane bound calcium in histamine secretion from rat peritoneal mast cells. Agents Actions 11: 324–329
White JR, Pearce FL (1983) Use of chlortetracycline to monitor calcium mobilization during histamine secretion from mast cells: a cautionary note. Anal Biochem 132: 1–5
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag, Berlin Heidelberg
About this chapter
Cite this chapter
Peachell, P.T., Pearce, F.L. (1985). Calcium Regulation of Histamine Secretion from Mast Cells. In: Marmé, D. (eds) Calcium and Cell Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70070-5_16
Download citation
DOI: https://doi.org/10.1007/978-3-642-70070-5_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70072-9
Online ISBN: 978-3-642-70070-5
eBook Packages: Springer Book Archive