Abstract
The original analysis for the inhalation method of measuring regional Cerebral Blood Flow (rCBF) was described solely in terms of compartmental analysis, and did not mention other possible flow indices (Obrist et al. 1975). At the same time, however, a problem was discovered in the use of the k1 (or f1) parameter, and an Initial Slope Index (ISI) was adapted from the intraarterial injection method (Olesen et al. 1971) and suggested as more reliable than f1 under certain conditions, for inhalation studies (Risberg et al. 1975).
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References
Obrist WD, Wilkinson WE (1980) The noninvasive Xe-133 method: Evaluation of CBF indices. In: Bes A, Geraud G (eds.) Cerebral circulation. Excerpta Medica, Amsterdam, pp. 119–124
Obrist WD, Thompson HK, Wang HS, Wilkinson WE (1975) Regional cerebral blood flow estimated by 133xenon inhalation. Stroke 6:245–256
Olesen J, Paulson OB, Lassen NA (1971) Regional cerebral blood flow in man determined by the initial slope of the clearance of intraarterially injected 133Xe. Stroke 2: 519–540
Prohovnik I (1984) Clinical studies of rCBF by two-dimensional noninvasive 133Xe clearance. In Spencer RP (ed) Interventional nuclear medicine. Grune and Stratton, New York, pp. 63 - 108
Prohovnik I, Knudsen E, Risberg J (1983) Accuracy of models and algorithms for determination of fast-compartment flow by noninvasive 133Xe clearance. In: Magistretti PL (ed) Functional radionuclide imaging of the brain. Raven Press, New York, pp. 87–115
Risberg J, Ali Z, Wilson EM, Wills EL, Halsey JH (1975) Regional cerebral blood flow by 133xenon inhalation: Preliminary evaluation of an initial slope index in patients with unstable flow compartments. Stroke 6: 142–148
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© 1985 Springer-Verlag Berlin Heidelberg
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Prohovnik, I., Knudsen, E., Risberg, J. (1985). Theoretical Evaluation and Simulation Test of the Initial Slope Index for Noninvasive rCBF. In: Hartmann, A., Hoyer, S. (eds) Cerebral Blood Flow and Metabolism Measurement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70054-5_7
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DOI: https://doi.org/10.1007/978-3-642-70054-5_7
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