Theory for Noninvasive Measurement of Oxygen Extraction Fraction by Intravenous Bolus Injection or Bolus Inhalation of 15-Oxygen
Oxygen extraction fraction (OEF) in human subjects has been measured by the continuous inhalation (Jones et al. 1976) or bolus inhalation method (Mintun et al. 1983). However, arterial sampling is necessary to measure the arterial tracer concentration. We have developed a theory and a mathematical procedure by which OEF can be measured noninvasively in humans by positron emission tomography (PET). Our model has not only a possibility of being noninvasive, but also many advantages over the previously established methods. Three tracers are administered by intravenous bolus injection or bolus inhalation: (1) O-15 labeled O2 as an OEF tracer, (2) a diffusible tracer, as a reference tracer for the OEF study, and also as a cerebral blood flow (CBF) tracer, (3) carbon monoxide, as a cerebral blood volume (CBV) tracer.
KeywordsPositron Emission Tomography Cerebral Blood Flow Cerebral Blood Volume Diffusible Tracer Noninvasive Measurement
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- Mintun MA, Raichle ME, Martin WRW, Herscovitch P (1983) Oxygen utilization measured by O-15 radiotracers and PET. J Nucl Med 24: p63Google Scholar