Theory for Noninvasive Measurement of Oxygen Extraction Fraction by Intravenous Bolus Injection or Bolus Inhalation of 15-Oxygen

  • S. Takagi
  • K. Ehara
  • P. J. Kenny
  • A. J. Gilson

Abstract

Oxygen extraction fraction (OEF) in human subjects has been measured by the continuous inhalation (Jones et al. 1976) or bolus inhalation method (Mintun et al. 1983). However, arterial sampling is necessary to measure the arterial tracer concentration. We have developed a theory and a mathematical procedure by which OEF can be measured noninvasively in humans by positron emission tomography (PET). Our model has not only a possibility of being noninvasive, but also many advantages over the previously established methods. Three tracers are administered by intravenous bolus injection or bolus inhalation: (1) O-15 labeled O2 as an OEF tracer, (2) a diffusible tracer, as a reference tracer for the OEF study, and also as a cerebral blood flow (CBF) tracer, (3) carbon monoxide, as a cerebral blood volume (CBV) tracer.

Keywords

Catheter Carbon Monoxide Beach Convolution 

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References

  1. Jones T, Chesler DA, Ter-Pogossian MM (1976) The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man. Brit J Radiol 49: 339–343PubMedCrossRefGoogle Scholar
  2. Mintun MA, Raichle ME, Martin WRW, Herscovitch P (1983) Oxygen utilization measured by O-15 radiotracers and PET. J Nucl Med 24: p63Google Scholar
  3. Subramanyam R, Alpert NM, Hoop B Jr, Brownell GL, Taveras JM (1978) A model for regional cerebral oxygen distribution during continuous inhalation of 15O2, C15O, and C15O2. J Nucl Med 19: 48–53PubMedGoogle Scholar

Copyright information

© Springer-Verlag Heidelberg 1985

Authors and Affiliations

  • S. Takagi
    • 2
  • K. Ehara
    • 1
  • P. J. Kenny
    • 1
  • A. J. Gilson
    • 1
  1. 1.Baumritter Institute of Nuclear MedicineMount Sinai Medical CenterMiami BeachUSA
  2. 2.Department of NeurologyTokai University, School of MedicineIsehara, KanagawaJapan

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