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Ethanol and Fibrogenesis in the Liver

  • Chapter
Alcohol Related Diseases in Gastroenterology

Abstract

Rapid advances in connective tissue research offer a new perspective on molecular and cellular events in alcoholic liver fibrosis, and also provide new quantitative approaches to monitoring its clinical course. Recently detected biological activities of distinct proteins of the interstitial matrix may be of fundamental importance for differentiated growth and regeneration in the liver (Rojkind and Kershenobich 1983), and the function of micro- and macrocirculation, of hepatocytes, and of Kupffer cells may be severely disturbed by the development of excess connective tissue. The tridimensional pattern of scarring in liver acini plays a pivotal role in the pathophysiology of collateral circulation and portal hypertension (Rappaport et al. 1983), and many problems of alcoholic liver disease are closely linked to hepatic fibrogenesis. This chapter will briefly review the morphologic pattern and functional implications of alcoholic liver fibrosis, describe the composition of the fibrotic matrix and its pathogenesis, and then discuss the clinical assessment of fibrogenesis in alcoholic liver disease.

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  1. Medizinische Klinik und Poliklinik, Abteilung für Innere Medizin mit Schwerpunkt Gastroenterologie, Freie Universität Berlin, Hindenburgdamm 30, 1000, Berlin 45, Federal Republik of Germany

    E. G. Hahn & D. Schuppan

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  1. E. G. Hahn
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  2. D. Schuppan
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  1. Medizinische Universitätsklinik Heidelberg Innere Medizin IV (Gastroenterologie), Bergheimer Strasse 58, D-6900, Heidelberg 1, Germany

    Helmut Karl Seitz  & Burkhard Kommerell  & 

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Hahn, E.G., Schuppan, D. (1985). Ethanol and Fibrogenesis in the Liver. In: Seitz, H.K., Kommerell, B. (eds) Alcohol Related Diseases in Gastroenterology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70048-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-70048-4_7

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