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Pathology of Alcoholic Liver Disease with Special Emphasis on Alcoholic Hepatitis

  • Chapter
Alcohol Related Diseases in Gastroenterology

Abstract

It has been widely recognized that alcoholism is one of the major sociomedical problems of modern society. It is also known that excessive alcohol intake is a factor in a significant percentage of all deaths, roughly 10% in the United States. It is associated with half of all traffic deaths, many involving teenagers. Cirrhosis of the liver, which ranks among the ten leading causes of death, is largely attributable to excessive alcohol consumption (Lieber 1978; Eckardt et al. 1981).

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References

  • Afshami P, Littenberg GD, Wollman J, Kaplowitz N (1978) Significance of microscopic cholangitis in alcoholic liver disease. Gastroenterology 75: 1045–1050

    Google Scholar 

  • Bailey RJ, Krasner N, Eddleston ALWF, Williams R, Tee DEH, Doniach D, Kennedy LA, Bachelor JR (1976) Histocompatibility antigens, autoantibodies, and immunoglobulins in alcoholic liver disease. Br Med J 2: 727–729

    PubMed  CAS  Google Scholar 

  • Basile A, Vitale G, Macor C, Scudeller G (1981) Hepatitis B virus infection in alcoholic cirrhosis. Br Med J 282: 1705–1706

    Google Scholar 

  • Bell H, Nordhagen R (1978) Association between HLA-BW40 and alcoholic liver diseases with cirrhosis. Br Med J 1: 822

    PubMed  CAS  Google Scholar 

  • Bernstein IM, Webster KH, Williams RC Jr, Strickland RG (1974) Reduction in circulating T lymphocytes in alcoholic liver disease. Lancet 2: 488–490

    PubMed  CAS  Google Scholar 

  • Berry RE Jr, Boland JP (1979) The economic cost of alcohol abuse. Free Press, New York

    Google Scholar 

  • Biava C (1964) Mallory alcoholic hyaline: a heretofore unique lesion of hepatocellular ergastoplasm. Lab Invest 13: 301–320

    Google Scholar 

  • Birschbach HR, Harinasuta W, Zimmerman HJ (1974) Alcoholic steatonecrosis. II. Prospective study of prevalence of Mallory bodies in biopsy specimens and comparison of severity of hepatic disease in patients with and without this histological feature. Gastroenterology 66: 1195–1202

    PubMed  CAS  Google Scholar 

  • Bjøneboe M, Prytz H (1976) The mononuclear phagocyte functions of the liver. In: Ferguson A, MacSween RNM (eds) Immunologic Aspects of the liver and intestinal tract. Garden City Press, Lancaster, pp 251–289

    Google Scholar 

  • Bjøneboe M, Prytz H, Orskov F (1972) Antibodies to intestinal microbes in serum of patients with cirrhosis of the liver. Lancet 1: 58–60

    Google Scholar 

  • Brunt PW, Kew MC, Shemer PJ, Sherlock S (1974) Studies in alcoholic liver disease in Britain. I. Clinical and pathological patterns related to natural history. Gut 15: 52–58

    PubMed  CAS  Google Scholar 

  • Buffet C, Attali P, Papoz L, Chaput JC, Etienne JP (1982) Evidence for previous hepatitis B virus infection in alcoholic cirrhosis. Digest Dis Sci 27: 473–474

    PubMed  CAS  Google Scholar 

  • Chalmers DM, Bullen AW, Levi AJ (1981) Evidence for previous hepatitis B virus infection in alcoholic cirrhosis. Br Med J 282: 819

    CAS  Google Scholar 

  • Cherrick GR, Potheir L, Dufour JJ, Sherlock S (1958) Immunologic response to tetanus toxoid inoculation in patients with hepatic cirrhosis. N Engl J Med 261: 340–342

    Google Scholar 

  • Christoffersen P, Poulsen H (1979) Alcoholic liver disease. In: MacSween RNM, Anthony PP, Scheuer PJ (eds) Pathology of the liver. Churchill Livingstone, Edinburgh, pp 232–247

    Google Scholar 

  • Christoffersen P, Braendstrup O, Juhl E, Poulsen H (1971) Lipogranulomas in human liver biopsies with fatty change. Acta Pathol Microbiol Scand [A] 79: 150–158

    CAS  Google Scholar 

  • Cochrane AMG, Moussouros A, Portmann B, McFarlane IG, Thomson AD, Eddieston ALWF, Williams R (1977) Lymphocyte cytotoxicity for isolated hepatocytes in alcoholic liver disease. Gastroenterology 72: 918–923

    PubMed  CAS  Google Scholar 

  • Delacroix DL, Reynaert M, Pauwels S, Geubel AP, Vaerman JP (1982) High serum levels of secretory IgA in liver disease. Dig Dis Sci 27: 333–340

    PubMed  CAS  Google Scholar 

  • Denk H, Eckerstorfer R (1977) Colchicine-induced Mallory body formation in the mouse. Lab Invest 36: 563–565

    PubMed  CAS  Google Scholar 

  • Denk H, Franke WW, Eckerstorfer R (1979) Formation and involution of Mallory bodies (“alcoholic hyalin”) in murine and human liver revealed by immunofluorescence microscopy with antibodies to prekeratin. Proc Natl Acad Sci USA 76: 4112–4116

    PubMed  CAS  Google Scholar 

  • Denk H, Franke WW, Dragosics B, Zeiler I (1981) Pathology of cytoskeleton of liver cells: demonstration of Mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes. Hepatology 1: 9–20

    PubMed  CAS  Google Scholar 

  • Eckardt MJ, Harford TC, Kaelber CT, Parker ES, Rosenthal LS, Ryback RS, Salmoiraghi GC, Vanderveen EV, Warren K (1981) Health hazards associated with alcohol consumption. JAMA 246: 648–666

    PubMed  CAS  Google Scholar 

  • Edmondson HA, Peters RL, Reynolds TB, Kuzma DT (1963) Sclerosing hyaline necrosis of the liver in the chronic alcoholic. A recognizable clinical syndrome. Ann Intern Med 59: 646–673

    PubMed  CAS  Google Scholar 

  • Edmondson HA, Peters RL, Frankel HH, Borowsky S (1967) The early stage of liver injury in the alcoholic. Medicine 46: 119–129

    PubMed  CAS  Google Scholar 

  • Feinman L, Lieber CS (1972) Hepatic collagen metabolism: effect of alcohol consumption in rats and baboons. Science 176: 795

    PubMed  CAS  Google Scholar 

  • Fessler JH, Fessler LI (1978) Biosynthesis of procollagen. Annu Rev Biochem 47: 129–162

    PubMed  CAS  Google Scholar 

  • Flax MH, Tisdale WA (1964) An electron microscopic study of alcoholic hyalin. Am J Pathol 44: 441–453

    PubMed  CAS  Google Scholar 

  • Franke WW, Denk H, Schmid E, Osborn M, Weber K (1979) Ultrastructural biochemical and immunologic characterization of Mallory bodies in griseofulvin-treated mice. Fimbriated rods of filaments containing prekeratin-like polypeptides. Lab Invest 40: 207–220

    Google Scholar 

  • Frei A, Zimmerman A, Weigand K (1982) Serum procollagen-III-aminopeptide (pp) as index of liver fibrosis — new morphometric evidence. Hepatology 2: 733

    Google Scholar 

  • French SW (1981) The Mallory body: structure, composition and pathogenesis. Hepatology 1: 76–83

    PubMed  CAS  Google Scholar 

  • French SW, Davies PL (1975) The Mallory body in the pathogenesis of alcoholic liver disease. In: Khanna JM, Israel Y, Kalent H (eds) Alcoholic liver pathology. Addiction Research Foundation, Toronto, pp 113–114

    Google Scholar 

  • French SW, Sim JS, Franks KE (1977) Alcoholic hepatitis. In: Fisher MM, Rankin JG (eds) Alcohol and the liver. Plenum, New York, pp 261–288

    Google Scholar 

  • Galambos JT (1972) Natural history of alcoholic hepatitis. III. Histological changes. Gastroenterology 63: 1026–1035

    PubMed  CAS  Google Scholar 

  • Gerber MA, Popper H (1972) Relation between central canals and portal tracts in alcoholic hepatitis. A contribution to the pathogenesis of cirrhosis in alcoholics. Human Pathol 3: 199–207

    CAS  Google Scholar 

  • Gluud C, Aldershvile J, Dietrichson O, Hardt F, Iversen K, Juhl E, Nielsen JO, Ryder LP, Skinhoj P, Srejgaard A (1980) A human leucozyte antigen in patients with alcoholic liver cirrhosis. Scand J Gastroenterology 15: 337–341

    CAS  Google Scholar 

  • Goldberg SJ, Mendenhall CL, Connell AM, Chedid A (1977) “Nonalcoholic” chronic hepatitis in the alcoholic. Gastroenterology 72:598–604

    Google Scholar 

  • Goudeau A, Maupas P, Dubois F, Coursaget P, Bougnoux P (1981) Hepatitis B infection in alcoholic liver disease and primary hepatocellular carcinoma in France. Prog Med Virol 27: 26–34

    PubMed  CAS  Google Scholar 

  • Hall EM, Ophulus W (1925) Progressive alcoholic cirrhosis. Report of four cases. Am J Pathol 1: 477–493

    PubMed  CAS  Google Scholar 

  • Harinasuta U, Zimmerman HJ (1971) Alcoholic steatonecrosis. I. Relationship between severity of hepatic disease and presence of Mallory bodies in the liver. Gastroenterology 60: 1036–1046

    PubMed  CAS  Google Scholar 

  • Havens WP Jr (1959) Liver disease and antibody formation. Int Arch Allergy Appl Immunol 14: 75–83

    PubMed  Google Scholar 

  • Helman RA, Temko MH, Nye SW, Fallon HJ (1971) Alcoholic hepatitis: natural history and evaluation of prednisolone therapy. Ann Intern Med 74: 311–321

    PubMed  CAS  Google Scholar 

  • Inoue K (1979) The clinicopathological features of the alcoholic liver injury in Japan and its etiological relationship to hepatitis B virus. Gastroenterol Jpn 12: 230–240

    Google Scholar 

  • Iseri OA, Gottlieb LS (1971) Alcoholic hyaline and megamitochondria as separate and distinct entities in liver disease associated with alcoholism. Gastroenterology 60: 1027–1035

    PubMed  CAS  Google Scholar 

  • Ishii H, Kanno T, Shigeta Y, Yasuraoka S, Kano S, Takeshita E, Tsuchiya M (1976) Hepatic gamma glutamyl transpeptidase activity: its activation by chronic ethanol administration. Gastroenterology 71: A–20/913

    Google Scholar 

  • Ishii H, Yasuraoka S, Shigeta Y, Kamiya T, Okuno F, Miyamoto K, Tsuchiya M (1978) Hepatic and intestinal gamma glutamyl transpeptidase activity: its activation by chronic ethanol administration. Life Sci 23: 1393–1398

    PubMed  CAS  Google Scholar 

  • Ishii H, Okuno F, Shigeta Y, Tsuchiya M (1980) Significance of serum gamma glutamyl transpeptidase as a marker of alcoholism. Pharmacol Biochem Behav 13: 95–99

    PubMed  CAS  Google Scholar 

  • Ishii H, Inagaki Y, Tsuchimoto K, Yamauchi H, Takagi S, Shigeta Y, Tsuchiya M (1982) Increased incidence of “non alcoholic” chronic hepatitis in alcoholics: evidence for autoantibodies to hepatocyte and antibody dependent cell-mediated cytotoxicity ( ADCC ). Hepatology 2: 704

    Google Scholar 

  • Iturriaga H, Pereda T, Estevez A, Ugarte G (1977) Serum immunoglobulin changes in alcoholic patients, Ann Clin Res 9: 39–43

    PubMed  CAS  Google Scholar 

  • Jensen DMBS, McFarlane IG, Portmann BS, Eddleston ALWF, Williams R (1978) Detection of antibodies detected against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis. N Engl J Med 299: 1–7

    PubMed  CAS  Google Scholar 

  • Karasawa T, Shikata T, Kushida T, Kaneda H, Ohknbo H (1979) Pathological study on alcoholic liver diseases in high and low incidence countries: comparison between Cincinnati, USA and Tokyo, Japan. Kanzo 20: 115–123

    Google Scholar 

  • Klion FM, Schaffner F (1968) Ultrastructural studies in alcoholic liver disease. Digestion 1: 2–14

    PubMed  CAS  Google Scholar 

  • Kowaloff FM, Phang JM, Granger AS, Downing SJ (1977) Regulation of proline oxidase activity by lactate. Pro Natl Acad Sci USA 74: 5368–5371

    CAS  Google Scholar 

  • Lane BP, Lieber CS (1966) Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets. Am J Pathol 49: 593–603

    PubMed  CAS  Google Scholar 

  • Lang JM, Ruscher H, Hasselmann JP, Grandjean P, Bigel P, Mayer S (1980) Decreased autologous rosette-forming T lymphocytes in alcoholic cirrhosis. Absence of correlation with other T cell markers and with delayed cutaneous hypersensitivity. Int Arch Allergy Appl Immunol 61: 337–343

    PubMed  CAS  Google Scholar 

  • Leevy CM (1962) Fatty liver: a study of 270 patients with biopsy proven fatty liver and a review of the literature. Medicine 41: 249–276

    PubMed  CAS  Google Scholar 

  • Leevy CM, Popper H, Sherlock S (1976) Diseases of the liver and biliary tract. Standardization of nomenclature, diagnostic criteria and diagnostic methodology. DHEW Publication No. (NIH) 76–725

    Google Scholar 

  • Leevy CM, Kanagasundaram N, Matsumoto K, Chen T (1979) Alcoholic hyalin and immunologic reactivity. In: Eddleston ALWF, Weber JCP, Williams R (eds) Immune reactions in liver disease. Pitman Medical, Tunbridge Wells, pp 195–207

    Google Scholar 

  • Lieber CS (1978) A public health strategy against alcoholism and its complications. Am J Med 65: 722–725

    PubMed  CAS  Google Scholar 

  • Lieber CS (1981) Metabolism and metabolic effects of ethanol. Semin Liver Dis 1: 189–202

    PubMed  CAS  Google Scholar 

  • Lieber CS (1982) Medical disorders of alcoholism: pathogenesis and treatment. Saunders, Philadelphia, p 263

    Google Scholar 

  • Lieber CS (1983) Precursor lesions of cirrhosis. Alcoholism 18: 5–20

    Google Scholar 

  • Lindy S, Pedersen FB, Turto H, Uitoo J (1971) Lactate, lactate dehydrogenase and protocollagen proline hydroxylase in rat skin autograft. Hoppe Seylers Z Physiol Chem 352: 113–118

    PubMed  CAS  Google Scholar 

  • Lishner MW, Alexander JF, Galambos JT (1971) Natural history of alcoholic hepatitis. I. The acute disease. Am J Dig Dis 16: 481–494

    Google Scholar 

  • Lundy J, Raaf JH, Deakins S, Wanebo HJ, Jacobs DA, Lee T-d, Jacobowitz D, Spear C, Oettgen HF (1975) The acute and chronic effects of alcohol on the human immune system. Surg Gynecol Obstet 141: 212–219

    PubMed  CAS  Google Scholar 

  • Mallory FB (1911) Cirrhosis of the liver. Five different types of lesions from which it may arise. Bull Johns Hopkins Hospital 22: 69–75

    Google Scholar 

  • Mann SW, Fuller GC, Rodil JV, Vidins EI (1979) Hepatic prolyl hydroxylase and collagen synthesis in patients with alcoholic liver disease. Gut 20: 825–832

    PubMed  CAS  Google Scholar 

  • Maruyama K, Feinman L, Okazaki I, Lieber CS (1981) Direct measurement of neutral collagenase activity in liver homogenates from baboons and humans. Biochim Biophys Acta 658: 124–131

    PubMed  CAS  Google Scholar 

  • Maruyama K, Feinman L, Fainsilber Z, Nakano M, Okazaki I, Lieber CS (1982) Mammalian collagenase increases in early alcoholic liver disease and decrease with cirrhosis. Life Sci 30: 1379–1384

    PubMed  CAS  Google Scholar 

  • Melendez M, Vargas-Tank L, Fuentes C, Armas-Merino R, Castillo D, Wolff C, Wegmann ME, Soto J (1979) Distribution of HLA histocompatibility antigens, ABO blood groups and RH antigens in alcoholic liver disease. Gut 20: 288–290

    Google Scholar 

  • Mills PR, Pennington TH, Kay P, McSween RNM, Watkinson G (1979) Hepatitis Bs antibody in alcoholic cirrhosis. J Clin Pathol 32: 778–782

    PubMed  CAS  Google Scholar 

  • Mills PR, Follett EAC, Urguhart GeD, Clements G, Watkinson G, MacSween RNM (1981) Evidence for previous hepatitis B virus infection in alcoholic cirrhosis. Br Med J 282: 437–438

    CAS  Google Scholar 

  • Miyamoto K, Ishii H, Takata H, Takagi S, Shigeta Y, Sekiguchi S, Suyama K, Kohno H, Tsuchiya M (1983) Association of HLA-B40 and DRW 9 with Japanese alcoholic liver cirrhosis. Pharmacol Biochem Behav [Suppl 1] 18: 467–471

    Google Scholar 

  • Morgan MY, Ross MGR, Ng CM, Adams DM, Thomas HC, Sherlock S (1980) HLA-B8, immunoglobulins, and antibody responses in alcohol-related liver disease. J Clin Pathol 33: 488–492

    PubMed  CAS  Google Scholar 

  • Morton JA, Fleming KA, Trowell JM, McGee JO’D (1980) Mallory bodies–immunohistochemical detection by antisera to unique non-prekeratin components. Gut 21: 727–733

    PubMed  CAS  Google Scholar 

  • Mutchnick MG, Lederman HM, Missirian A, Hohnson AG (1981) In vitro synthesis of IgG by peripheral blood lymphocytes in chronic liver disease. Clin Exp Immunol 43: 370–375

    PubMed  CAS  Google Scholar 

  • Nakano M, Worner TM, Lieber CS (1982) Perivenular fibrosis in alcoholic liver injury: ultrastructure and histologic progression. Gastroenterology 83: 777–785

    PubMed  CAS  Google Scholar 

  • Nei J, Matsuda Y, Takada A (1983) Chronic hepatitis induced by alcohol. Dig Dis Sci 28: 207–215

    PubMed  CAS  Google Scholar 

  • Niemela O, Risteli L, Sotaniemi EA (1983) Aminoterminal propeptide of type III procollagen in serum in alcoholic liver disease. Gastroenterology 85: 254–259

    PubMed  CAS  Google Scholar 

  • Okazaki I, Feinman L, Lieber CS (1977) Hepatic mammalian collagenase: development of an assay and demonstration of reversal activity after ethanol consumption. Gastroenterology 73: 1236

    Google Scholar 

  • Okazaki I, Feinman L, Maruyama K, Fainsilber Z, Nakano M, Lieber CS (1983) Development of an assay for mammalian hepatic collagenase and study of the effect of ethanol on enzyme activity. In: Lieber CS (ed) Biological approach to alcoholism. U.S. Department of Health and Human Services (ADM 83–1261), Washington, D.C., pp 392–398

    Google Scholar 

  • Paronetto F (1981) Immunologic factors in alcoholic liver disease. Semin Liver Dis 1: 232–243

    PubMed  CAS  Google Scholar 

  • Petersen PU (1977) Alcoholic hyalin, microfilaments and microtubules in alcoholic hepatitis. Acta Pathol Microbiol Scand 85: 384–394

    CAS  Google Scholar 

  • Pettigrew NM, Goudie RB, Russell RI (1972) Evidence for a role of hepatitis virus B in chronic alcoholic liver disease. Lancet 2: 724

    PubMed  CAS  Google Scholar 

  • Popper H (1977) The pathogenesis of alcoholic cirrhosis. In: Fisher MM, Rankin JG (eds) Alcohol and the liver. Plenum, New York, pp 289–305

    Google Scholar 

  • Popper H, Lieber CS (1980) Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am J Path 98: 695–716

    PubMed  CAS  Google Scholar 

  • Popper H, Szanto PB, Parathasarathy M (1955) Florid cirrhosis - a review of 35 cases. Am J Clin Pathol 25: 889–901

    PubMed  CAS  Google Scholar 

  • Porta EA, Hartroft WS, de la Iglesia FA (1967) Structural and ultrastructural hepatic lesions associated with acute and chronic alcoholism in man and experimental animals. In: Maickel RP (ed) Biochemical factors in alcoholism. Pergamon, Oxford, pp 201–238

    Google Scholar 

  • Rohde H, Vargas L, Hahn E, Kalbfleisch H, Bruguera M, Timpl R (1979) Radioimmunoassay for type III procollagen peptide and its application to human liver disease. Eur J Clin Invest 9: 451–459

    PubMed  CAS  Google Scholar 

  • Rubin E, Lieber CS (1968) Alcohol-induced hepatic injury in nonalcoholic volunteers. N Engl J Med 278: 869–876

    PubMed  CAS  Google Scholar 

  • Rubin E, Lieber CS (1974) Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. N Engl J Med 290: 128–135

    PubMed  CAS  Google Scholar 

  • Scott BB, Rajah SM, Losowsky MS (1977) Histocompatibility antigens in chronic liver disease. Gastroenterology 72: 122–125

    PubMed  CAS  Google Scholar 

  • Smith WI Jr, Van Thiel DH, Whiteside T, Janoson B, Magovern I, Puet T, Rabin BS (1980) Altered immunity in male patients with alcoholic liver disease: evidence for defective immune regulation. Alcoholism Clin Exp Res 4: 199–206

    Google Scholar 

  • Sorrell MF, Leevy CM (1972) Lymphocyte transformation and alcoholic liver injury. Gastroen¬terology 63: 1020–1025

    CAS  Google Scholar 

  • Svoboda DJ, Manning RT (1964) Chronic alcoholism with fatty metamorphosis of the liver. Am J Pathol 44: 645–662

    PubMed  CAS  Google Scholar 

  • Takagi S (1979) Altered humoral and cell-mediated immunity in chronic alcoholics. Its relation to the development of liver injury. J. Keio Med. Soc. 76: 184–195

    CAS  Google Scholar 

  • Theofilopoulos AN, Dixon FI (1980) Immune complexes in human diseases. Am J Pathol 100: 531–594

    Google Scholar 

  • Thomas HC, Freni M, Sanchez-Tapias J, DeVilliers D, Jain S, Sherlock S (1976) Peripheral blood lymphocyte populations in chronic liver disease. Clin Exp Immunol 26: 222–227

    PubMed  CAS  Google Scholar 

  • Tsuchimoto K (1982) Detection of antibody and antibody dependent cell-mediated cytotoxicity (ADCC) against Chang liver cell in alcohol liver disease. Jpn J Gastroenterol 79: 1581–1588

    CAS  Google Scholar 

  • Van Waes L, Lieber CS (1977a) Early perivenular sclerosis in alcoholic fatty liver: an index of progressive liver injury. Gastroenterology 73: 646–650

    PubMed  Google Scholar 

  • Van Waes L, Lieber CS (1977b) Glutamate dehydrogenase, a reliable marker of liver cell necrosis in the alcoholic. Br Med J 2: 1508–1510

    PubMed  Google Scholar 

  • Villa E, Rubbiani L, Barchi T, Ferretti I, Grisendi A, De Palma M, Bellentani S, Manerti F (1982) Susceptibility of chronic symptomless HBsAg carriers to ethanol-induced hepatic damage. Lancet 2: 1243–1244

    PubMed  CAS  Google Scholar 

  • Wands JR, Dienstag JL, Weake JR, Koff RS (1978) Proliferative and secretory B cell activity in severe alcoholic liver disease. Gastroenterology 75: 992

    Google Scholar 

  • Yokoo H, Minick OT, Batti F, Kent G (1972) Morphologic variants of alcoholic hyalin. Am J Pathol 69: 25–40

    PubMed  CAS  Google Scholar 

  • Zakim D, Boyer TD, Montgomery C, Kanas N (1982) Alcoholic liver disease. In: Zakim D, Boyer T (eds) A texbook of liver disease. Saunders, Philadelphia, pp 739–789

    Google Scholar 

  • Zetterman RK, Leevy CM (1975) Immunologic reactivity and alcoholic liver disease. Bull N Y Acad Med 51: 533–544

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine Division of Gastroenterology and Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, 160, Japan

    H. Ishii, I. Okazaki & M. Tsuchiya

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  1. H. Ishii
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  2. I. Okazaki
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  3. M. Tsuchiya
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  1. Medizinische Universitätsklinik Heidelberg Innere Medizin IV (Gastroenterologie), Bergheimer Strasse 58, D-6900, Heidelberg 1, Germany

    Helmut Karl Seitz  & Burkhard Kommerell  & 

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Ishii, H., Okazaki, I., Tsuchiya, M. (1985). Pathology of Alcoholic Liver Disease with Special Emphasis on Alcoholic Hepatitis. In: Seitz, H.K., Kommerell, B. (eds) Alcohol Related Diseases in Gastroenterology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70048-4_16

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