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Ethanol and the Immune System

  • Chapter
Alcohol Related Diseases in Gastroenterology

Abstract

Although the metabolic pathways of ethanol are well understood, the pathogenesis of tissue damage and the development of cirrhosis are far from clear. While alcohol is considered by some investigators to be a hepatotoxic substance that produces a dose- and time-related hepatotoxic damage (Peguignot et al. 1974; Lelbach 1976; Rankin 1977), several observations militate against this hypothesis: the variation of hepatotoxic damage in patients with similar alcohol intake is considerable and only a small percentage of alcoholic patients develop cirrhosis and/or alcoholic hepatitis (Galambos 1974). In the search for alternative explanations, alterations of the immune response have been assuming a growing importance and a number of altered immune reactions have been observed in patients with prolonged alcohol abuse.

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  1. Immunopathology Laboratory, Veterans Administration Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA

    F. Paronetto

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  1. Medizinische Universitätsklinik Heidelberg Innere Medizin IV (Gastroenterologie), Bergheimer Strasse 58, D-6900, Heidelberg 1, Germany

    Helmut Karl Seitz  & Burkhard Kommerell  & 

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Paronetto, F. (1985). Ethanol and the Immune System. In: Seitz, H.K., Kommerell, B. (eds) Alcohol Related Diseases in Gastroenterology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70048-4_15

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  • DOI: https://doi.org/10.1007/978-3-642-70048-4_15

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