Neurology pp 337-339 | Cite as

Discussion of Clinical Trials Relating to Peripheral Neuropathies

  • A. K. Asbury
Conference paper


Two major types of peripheral neuropathy have been the subject of clinical trials. These are diabetic polyneuropathy and acquired demyelinating polyneuropathies, acute and chronic. The acute form is Guillain-Barré syndrome (GBS), and the chronic form is known as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Hughes has, quite rightly, emphasized only the controlled studies of these polyneuropathies.


Glycemic Control Peripheral Neuropathy Plasma Exchange Diabetic Neuropathy Mayo Clin Proc 
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  1. 1.
    Asbury AK (1984) Strategies in the clinical investigation of peripheral neuropathies. In: Sobue I (ed) Peripheral neuropathy. Excerpta Medica, Amsterdam, pp 75–79 (International Congress Series 662 )Google Scholar
  2. 2.
    GBS Study Group (1985) Plasmapheresis and acute Guillain-Barré syndrome. Neurology 35: 1096–1104Google Scholar
  3. 3.
    Graf RJ, Halter JB, Pfeifer MA, Halar E, Brozovich F, Porte DF Jr (1981) Glycemic control and nerve conduction abnormalities in non-insulin dependent diabetic subjects. Ann Intern Med 94: 307–311PubMedGoogle Scholar
  4. 4.
    Greene DA, Brown MJ, Braunstein SN, Schwartz SS, Asbury AK, Winegrad AI (1981) Comparison of clinical course and sequential electrophysiological tests in diabetes with symptomatic polyneuropathy and its implications for clinical trials. Diabetes 30: 139–147PubMedCrossRefGoogle Scholar
  5. 5.
    Service FJ, Dabue JR, O’Brien PC, Zimmerman BR, Swanson CJ, Brennan MD, Dyck PJ (1983) Effect of blood glucose control on peripheral nerve function in diabetic patients. Mayo Clin Proc 58: 283–289PubMedGoogle Scholar
  6. 6.
    Service FJ, Rizza RA, Daube JR, O’Brien PC, Dyck PJ (1985) Near normal glycemia improved nerve conduction and vibratory sensation in diabetic neuropathy. Diabetologia (in press)Google Scholar
  7. 7.
    Windebank AJ (1983) Diabetic control and peripheral neuropathy — editorial. Mayo Clin Proc 58: 344–346PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • A. K. Asbury
    • 1
  1. 1.Department of NeurologyHospital of the University of PennsylvaniaPhiladelphiaUSA

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