Skip to main content
SpringerLink
Log in

Clinical Relevance

  • Conference paper
Transmitter Molecules in the Brain

Part of the book series: Basic and Clinical Aspects of Neuroscience ((BASIC,volume 2))

Abstract

This section considers the involvement of neurotransmitters in the major mental illnesses and in degenerative disorders of the central nervous system: Parkinson’s disease, Huntington’s disease and Alzheimer-type dementia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408–417

    Article  PubMed  CAS  Google Scholar 

  2. Bowen DM, Davison AN, Francis PT, Palmer AM, Pearce BR (1985) Neurotransmitter and metabolic dysfunction in Alzheimer’s dementia: relationship to histopathological features. In: Rose FC (ed) Modern approaches to the dementias; Interdisciplinary topics in gerontology, vol 19. Karger, Basel, pp 156–174

    Google Scholar 

  3. Christie JE, Shering A, Ferguson J, Glen AIM (1981) Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia. Br J Psychiatry 138: 46–50

    Article  PubMed  CAS  Google Scholar 

  4. Crow TJ (1980) Molecular pathology of schizophrenia: more than one disease process? Br Med J 280: 1–9

    Article  Google Scholar 

  5. De Souza EB, Whitehouse PJ, Kuhar MJ, Price DL, Vale WW (1986) Reciprocal changes in corticotropin-releasing factor ( CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer’s disease. Nature 319: 593–595

    Article  PubMed  Google Scholar 

  6. Garattini S, Samanin R (1984) Drugs: guide and caveats to explanatory and descriptive approaches. I. A critical evaluation of the current status of antidepressant drugs. J Psychiatr Res 18: 373–390

    Article  PubMed  CAS  Google Scholar 

  7. Goodwin GM, De Souza RJ, Green AR (1985) Presynaptic serotonin receptor-mediated response in mice attenuated by anti-depressant drugs and electroconvulsive shock. Nature 317: 531–533

    Article  PubMed  CAS  Google Scholar 

  8. Gusella JF, Wexler NS, Conneally M, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, Young AB, Shoulson I, Bonilla E, Martin JB (1983) A polymorphic DNA marker genetically linked to Huntington’s disease. Nature 306: 234–238

    Article  PubMed  CAS  Google Scholar 

  9. Hardy J, Adolfsson R, Alafuzoff I, Bucht G, Marcusson J, Nyberg P, Perdahl E, Wester P, Winblad B (1985) Transmitter defi-cits in Alzheimer’s disease. Neurochem Int 7: 545–563

    Article  PubMed  CAS  Google Scholar 

  10. Hornykiewicz O (1979) Brain dopamine in Parkinson’s disease and other neurological disturbances. In: Horn AS, Korf J, Westerink BHC (eds) The neurobiology of dopamine. Academic, London, pp 633–654

    Google Scholar 

  11. Johnstone EC, Crow TJ, Frith CD, Stevens M, Kreel L, Husband J (1978) The dementia of dementia praecox. Acta Psychiatr Scand 57: 305–324

    Article  PubMed  CAS  Google Scholar 

  12. Mackay A, Iversen L, Rossor M, Spokes E, Bird E, Arregui A, Creese I, Snyder S (1982) Increased brain dopamine and dopamine receptors in schizophrenia. Arch Gen Psychiatry 39: 991–997

    PubMed  CAS  Google Scholar 

  13. Reynolds GP (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature 305: 527–529

    Article  PubMed  CAS  Google Scholar 

  14. Rossor MN, Mountjoy CQ, Roth M, Reynolds GP (1985) Ascending systems in Alzheimer’s disease. In: Rose FC (ed) Modern approaches to the dementias; Interdisciplinary topics in gerontology, vol 19. Karger, Basel, pp 198–212

    Google Scholar 

  15. Roth M (1986) The association of clinical and neurological findings and its bearing on the classification and aetiology of Alzheimer’s disease. Br Med Bull 42: 42–50

    PubMed  CAS  Google Scholar 

  16. Siever LJ, Uhde TW (1984) New studies and perspectives on the noradrenergic receptor system in depression: effects of the α2-adrenergic agonist clonidine. Biol Psychiatry 19: 131–156

    PubMed  CAS  Google Scholar 

  17. Spokes EGS (1980) Neurochemical alterations in Huntington’s chorea. A study of post-mortem brain tissue. Brain 103: 179–210

    Article  PubMed  CAS  Google Scholar 

  18. Sulser F (1983) Deamplification of noradrenergic signal transfer by antidepressants; a unified catecholamine-serotonin hypothesis of affective disorders. Psychopharmacol Bull 19: 300–304

    PubMed  CAS  Google Scholar 

  19. Terry RD, Katzman R (1983) Senile dementia of the Alzheimer type. Ann Neurol 14: 497–506

    Article  PubMed  CAS  Google Scholar 

  20. Weinberger DR (1984) Computed tomography (CT) findings in schizophrenia: speculation on the meaning of it all. J Psychiatr Res 18: 477–490

    Article  PubMed  CAS  Google Scholar 

  21. Yates CM, Simpson J, Gordon A, Maloney AFJ, Allison Y, Ritchie IM, Urquhart A (1983) Catecholamines and cholinergic enzymes in presenile and senile Alzheimer-type dementia and Down’s syndrome. Brain Res 280: 119–126

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside, Edinburgh, UK

    Janice E. Christie

Authors
  1. Janice E. Christie
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Christie, J.E. (1987). Clinical Relevance. In: Transmitter Molecules in the Brain. Basic and Clinical Aspects of Neuroscience, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69950-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69950-4_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13701-6

  • Online ISBN: 978-3-642-69950-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation