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Biological Response to Nitrogen Oxide

  • K. Jacyszyn
  • W. Lesiecki
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 8)

Abstract

The human organism responds to the low concentration of nitrogen oxides (NOx) contained in the atmosphere by a reaction to increase the levels of methaemoglobin, (MetHb) an increase in reduced glutathione (GSH), in the activity of glucose-6-phosphate dehydrogenase and first of all an increase in the activity of methaemoglobin reductase (MetHb-Red). The same results were found in groups of rabbits, which have been injected with different doses of sodium nitrite (NaNO2). With the use of native and pure enzymes investigations “in vitro” showed activation and then inhibition of enzymes with rising concentration of NaNO2.

Key words

Nitrogen oxide Induction Enzymatical reduction system 

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • K. Jacyszyn
    • 1
  • W. Lesiecki
    • 1
  1. 1.Department of ToxicologyMedical Academy of WroclawPoland

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