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The Induction and Assessment of Rat Gastric Mucosal Lesions

  • G. K. Salmon
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 8)

Abstract

A technique for examination of the rat gastric mucosa by the use of a flexible endoscope was described. The procedure does not require prior surgery and can be repeated over long time periods making it specifically useful for evaluation of chronic lesion. The insertion of a fine nylon cannula down through the endoscope permits the direct application of controlled doses of irritants onto a defined region of the gastric mucosa. The latter procedure allows for detection of early macroscopic changes with the facility for repeat observation in individual animals.

Key words

Endoscopy Gastroscopy Rat Gastric mucosa 

References

  1. Fukawa K, Kawano O, Misaki N, Uchida M and Irino O (1983) Experimental studies on gastric ulcer (4) sequential observation and evaluation of gastric ulcers by endoscope in the rat. Japan J Pharmacol 33, 175–179CrossRefGoogle Scholar
  2. Meyrat P, Kappeler M, Halter F (1982) A simple method for repeated gastroscopy in the rat: its application in the research on cytoprotection. Scand J Gastroenterol 78, 54Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • G. K. Salmon
    • 1
  1. 1.Smith Kline and French Research LtdWelwyn, HertsUK

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