The Leukemogenic Effect of Haloperidol in AKC3 F1 Hybrid Mice
The side effect of some medicaments may have carcinogenic effects. In 1982 Fey et al. found monocytic-like leukemia in animal experiments after administration of Haloperidol. That is why it was decided to compare the leukemogenic effects of Haloperidol and Droperidol in AKC3 F1 mice which have a low incidence of leukemia. The animals got the medicaments in 5 mg/kg body weight once a week for 7 weeks. In the 8th month autopsy, histological examination and flow cytometric analyses were carried out. According to the results Haloperidol but not Droperidol had a leukemogenic effect. The leukemia involved all lymphoid organs, except the thymus. This is very surprising because the target role of thymus is well known in chemically induced leukemia.