The Leukemogenic Effect of Haloperidol in AKC3 F1 Hybrid Mice

  • I. Ember
  • V. Thomázy
  • L. Mátyus
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 8)

Abstract

The side effect of some medicaments may have carcinogenic effects. In 1982 Fey et al. found monocytic-like leukemia in animal experiments after administration of Haloperidol. That is why it was decided to compare the leukemogenic effects of Haloperidol and Droperidol in AKC3 F1 mice which have a low incidence of leukemia. The animals got the medicaments in 5 mg/kg body weight once a week for 7 weeks. In the 8th month autopsy, histological examination and flow cytometric analyses were carried out. According to the results Haloperidol but not Droperidol had a leukemogenic effect. The leukemia involved all lymphoid organs, except the thymus. This is very surprising because the target role of thymus is well known in chemically induced leukemia.

Key words

Leukemogens Carcinogens Haloperidol Droperidol 

Reference

  1. Fey F, Wunderlich B, Teichmann G, Kohler S (1982) Carcinogenesis 3: 223–224PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • I. Ember
    • 1
  • V. Thomázy
    • 1
  • L. Mátyus
    • 1
  1. 1.Department of Hygiene, Department of Pathology, Department of BiophysicsUniversity Medicine SchoolDebrecenHungary

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