Abstract
Lymphotropic Papovavirus (LPV) is a new member of the Polyomavirus genus of the Papovaviridae (zur Hausen and Gissmann, 1979). It was isolated from an African Green Monkey B-lymphoblastoid line and subsequently adapted to the human B-lymphoma line BJA-B. LPV shows a highly restricted host range in vitro. Only continuously growing cells of primate B-lymphocyte origin, i.e. B-lymphoma lines and B-lymphoblastoid cell lines immortalised by Epstein Barr Virus (EBV) are permissive to productive infection by LPV particles (zur Hausen and Gissmann, 1979; Brade et al., 1981; Takemoto et al., 1982). Normal lymphocytes, even with mitogenic stimulation are not permissive to LPV.
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© 1984 Springer-Verlag Berlin · Heidelberg
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Pawlita, M., Mosthaf, L., Clad, A., Gruss, P. (1984). Genome Structure and Host Range Restriction of the Lymphotropic Papovavirus (LPV): Identification of a Viral Lymphocyte Specific Enhancer Element. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_5
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DOI: https://doi.org/10.1007/978-3-642-69860-6_5
Publisher Name: Springer, Berlin, Heidelberg
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