Abstract
Recent work from many laboratories has demonstrated that the chromosomal locus containing the myc oncogene is the site of an extraordinary number of rearrangements. These rearrangements take the form of translocations, amplifications, and retroviral insertions and examples have been found in chickens, mice, and humans. In addition, such alterations in the myc locus appear to be associated with neoplasias of primarily lymphoid origin although myc amplification has also been observed in human neuroendocrine tumors and small cell lung carcinomas (see other papers in this volume).
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References
Abrams HD, Rohrsehneider LR, Eisenman RN (1982) Nuclear location of the putative transforming protein of avian myelocytomatosis virus. Cell 29: 427–439
Alitalo K, Ramsay G, Bishop JM, Pfeifer SO, Colby WW, Levinson AD (1983a) Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature 306: 274–277
Alitalo K, Schwab M, Lin CC, Varmus HE, Bishop JM (1983b) Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci USA 80: 1707–1711
Bernard O, Cory S, Gerondakis S, Webb E, Adams JM (1983) Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumors. EMBO J 2: 2375–2383
Bunte T, Greiser-Wilke I, Donner P, Moelling K (1982) Association of gag-myc proteins from avian myelocytomatosis virus wild-type and mutants with chromatin. EMBO J 1: 919–927
Campisi J, Gray HE, Pardee AB, Dean M, Sonenshein GE (1984) Cell cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell 36: 241–247
Donner P, Greiser-Wilke I, Moelling K (1982) Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus. Nature 296: 262–266
Eisenman RN, Linial M, Groudine M, Shaikh R, Brown S, Neiman PE (1980) Recombination in the avian oncoviruses as a model for the generation of defective transforming viruses. Cold Spring Harbor Symp Quant Biol 44: 1235–1247
Hann SR, Abrams HD, Rohrsehneider LR, Eisenman RN (1983) Proteins encoded by the v-myc and c-myc oncogenes: Identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Cell 34: 789–798
Hann SR, Bender MA, Eisenman RN (1984) Analysis and purification of v-myc proteins using anti-peptide antibodies. In: Cancer Cells 2/Oncogenes and Viral Genes. GF VandeWoude, AJ Levine, WC Topp and JD Watson eds. Cold Spring Harbor Laboratory, New York
Hayman MJ (1983) Avian acute leukemia viruses. Current Topics in Microbiology and Immunology 98: 109–126
Kelly K, Cochran BH, Stiles CD, Leder P (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35: 603–610
Land H, Parada LP, and Weinberg RA (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304: 596–602
Pachl C, Schubach W, Eisenman R, Linial M (1983) Expression of c-myc RNA in bursal lymphoma cell lines: Identification of c-myc-encoded proteins by hybrid-selected translation. Cell 33: 335–344
Palmieri S, Kahn P, Graf T (1983) Quail embryo fibroblasts transformed by four v-myc-containing virus isolates show enhanced proliferation but are non-tumorigenic. EMBO J 2: 2385–2389
Rabbitts TH, Hamlyn PH, Baer R (1983) Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. Nature 306: 760–765
Royer-Pokora B, Beug H, Clavier M, Winkhardt H-J, Friis RR, Graf T (1978) Transformation parameters in chicken fibroblasts transformed by AEV and MC29 avian leukemia viruses. Cell 13: 751–760
Saito H, Hayday A, Wiman K, Hayward WS, Tonegawa S (1983) Activation of the c-myc gene by translocation: A model for translational control. Proc Natl Acad Sci USA 80: 7476–7480
Watson DK, Psallidopoulos MC5 Samuel KP, Della-Favera R, Papas TS (1983) Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product. Proc Natl Acad Sci USA 80: 3642–3645
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© 1984 Springer-Verlag Berlin · Heidelberg
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Eisenman, R.N., Hann, S.R. (1984). myc-Encoded Proteins of Chickens and Men. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_33
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DOI: https://doi.org/10.1007/978-3-642-69860-6_33
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