Abstract
The characteristic chromosomal translocation found in many B cell tumors results in the joining of a c-myc oncogene (from murine chromosome 15) to an immunoglobulin heavy chain switch region (chromosome 12—Perry, 1983; Robertson, 1983). This translocation has several consequences. One is that the c-myc gene is frequently truncated, losing part or all of its 5′-most exon (Stanton et al., 1983; ar-Rushdi, et al., 1983; Gelman, et al., 1983; Saito, et al., 1983). A second is increased transcription of the truncated c-myc gene; this transcription often originates from adventitious promotors in the first intron (Stanton, et al., 1983; Hamlyn and Rabbitts, 1983; Mushinski et al., 1983; Adams et al., 1983; Erikson, et al., 1983a). Many have hypothesized that a third consequence of this rearrangement is oncogenesis. In virtually all chicken lymphomas induced by avian leukosis virus, the c-myc gene has been activated by proviral insertion (Hayward, et al., 1981). On the other hand, in erythroblastoid tumors induced by the same virus, c-myc is never activated (however, c-erb is activated—Fung, et al., 1983). The conclusion from chickens, that activation of c-myc is necessary for lymphomagenesis, would also seem to apply to activation of murine c-myc by translocation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adams, J.M., Gerondakis, S., Webb, E., Corcoran, L.M., and Cory, S. 1983. Proc. Natl. Acad. Sci. USA 80: 1982.
ar-Rushdi, A., Nishikura, K., Erikson, J., Watt, R., Rovera, G., and Croce, C.M. 1983. Science 222: 390.
Battey, J., Moulding, C., Taub, R., Murphy, W., Stewart, T., Potter, H., Lenoir, G., and Leder, P. 1983. Cell 34: 779.
Calame, K., Kim, S., Lalley, D., Hill, R., Davis, M., and Hood, L. 1982. Proc, Natl, Acad, Sci, USA 79: 6994.
Cory, S., Gerondakis, S., and Adams, J. M. 1983. EMBO Journal 2: 697.
Croce, C.M., Thierfelder, W., Erikson, J., Nishikura, K., Finan, J., Lenoir, G.M., and Nowell, P.C. 1983. Proc. Natl. Acad. Sci. USA 80: 6922.
Davis, M.M., Kim, S.K., and Hood, L. 1980. Cell 22: 1.
Dunnick, W., Shell, B.E., and Dery, C. 1983. Proc. Natl. Acad. Sci. USA 80: 7269.
Erikson, J., Ar-Rushdi, A., Drivinga, H.L., Nowell, P.C., and Croce, C.M. 1983a. Proc. Natl. Acad. Sci. USA 80: 820.
Erikson, J., Nishikura, K., ar-Rushdi, A., Finan, J., Emanuel, B., Lenoir, G., Nowell, P.C., and Croce, C.M. 1983b. Proc. Natl. Acad. Sci. USA 80: 7581.
Fung, Y.-K.T., Lewis, W.G., Crittenden, L.B., and Kung, H.-J. 1983. Cell 33: 357.
Gelmann, E.P., Psallidopoulos, M.C., Papas, T.S., and Favera, R.D. 1983. Nature 306: 799.
Hamlyn, P.H. and Rabbitts, T.H. 1983. Nature 304: 135.
Hayward, W.S., Neel, B.G., and Astrin, S.M. 1981. Nature 290: 475.
Leder, P., Battey, J., Lenoir, G., Moulding, C., Murphy, W., Potter, H., Stewart, T., and Taub, R. 1983. Science 222: 765.
Marcu, K.B., Lang, R.B., Stanton, L.W., and Harris, L.J. 1982. Nature 298: 87.
Mushinski, J. F., Bauer, S. R., Potter, M., and Reddy, E. P. 1983. Proc. Natl. Acad. Sci. USA 80: 1073.
Neuberger, M.S., and Calabi, F. 1983. Nature 305: 240.
Nikaido, T., Yamawaki-Kataoka, Y., and Honjo, T. 1982. J. Biol. Chem. 257: 7322.
Nishikura, K., ar-Rushdi, A., Erikson, J., Watt, R., Rovera, G., and Croce, C.M. 1983. Proc. Natl. Acad. Sci. USA 80: 4822.
Perry, R.P. 1983. Cell 33: 647.
Razin, A., and Riggs, A.D. 1980. Science 210: 604.
Rigby, P. W. J., Dieckmann, M., Rhodes, C., and Berg, P. 1977. J. Molec, Biol. 113: 237.
Robertson, M. 1983. Nature 306: 733.
Saito, H., Hayday, A.C., Wiman, K., Hayward, W.S., and Tonegawa, S. 1983. Proc. Natl. Acad. Sci. USA 80: 7476.
Southern, E.M. 1975. J. Molec. Biol. 98: 503.
Stanton, L.W., Watt, R., and Marcu, K.B. 1983. Nature 303: 401.
Stanton, L.W., Yang, J.-Q., Eckhardt, L.A., Harris, L.J., Birshtein, B.K., and Marcu, K.B. 1984. Proc. Natl. Acad. Sci. USA, in press.
Subak-Sharpe, J.H. 1967. Brit. Med. Bull. 23: 161.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Dunnick, W., Baumgartner, J., Fradkin, L., Schultz, C. (1984). DNA Sequences Involved in the Rearrangement and Expression of the Murine c-myc Gene. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-69860-6_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69862-0
Online ISBN: 978-3-642-69860-6
eBook Packages: Springer Book Archive