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HLA-D Region Monoclonal Antibodies

  • Conference paper
Histocompatibility Testing 1984

Abstract

This is the first Histocompatibility Testing Workshop in which monoclonal antibodies have been featured as reagents separated from conventional antisera. In view of the virtually unlimited supply of a monoclonal antibody, its usually very high titre and its exquisite specificity for a particular epitope it appears to be an ideal reagent for the accurate definition of HLA specificity. The questions that this study was planned to answer were:

  1. 1.

    Do monoclonal antibodies work as well or better than conventional antisera for the definition of known antigens?

  2. 2.

    Can they identify new specificities?

  3. 3.

    Can they contribute extra information not easily obtainable with conventional antisera?

  4. 4.

    Can monoclonal antibodies be used in serological tissue typing in the same way as conventional antisera or do they need special handling?

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References

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Author information

Authors and Affiliations

  1. Imperial Cancer Research Fund, P.O. Box 123, Lincoln’s Inn Fields, London, WC2A 3PX, UK

    J. G. Bodmer & L. J. Kennedy

  2. Department of Pathology, Hokkaido University, School of Medicine, Kata 14 jo, Nishi 5, Kata-Ku, Sapporo, Japan

    M. Aizawa

  3. Tissue Typing Laboratory, Department of Clinical Immunology, Royal Perth Hospital, Perth, Western Australia, Australia, 6000

    R. L. Dawkins

  4. Hospital St. Louis, Institut de Recherches Sur les Maladies du Sang, 2 Place du Docteur Fournier, 75475, Paris Cedex 10, France

    V. Lepage

  5. Cattedra di Genetica Medica, Via Portuense 292, 00149, Rome, Italy

    M. C. Mazzilli

  6. Istituto di Genetica Medica, Via Santena 19, 10126, Torino, Italy

    P. Richiardi

Authors
  1. J. G. Bodmer
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  2. L. J. Kennedy
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  3. M. Aizawa
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  4. R. L. Dawkins
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  5. V. Lepage
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  6. M. C. Mazzilli
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  7. P. Richiardi
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Editor information

Editors and Affiliations

  1. Labor für Immungenetik, Kinderpoliklinik der Universität, Pettenkoferstraße 8a, 8000, München 2, Bundesrepublik Deutschland

    Ekkehard D. Albert

  2. Biometrische Abteilung, Diabetes Forschungsinstitut an der Universität, Auf’m Hennekamp 65, 4000, Düsseldorf 1, Bundesrepublik Deutschland

    Max P. Baur

  3. Institut für Blutgruppenserologie der Universität, Spitalgasse 4, 1090, Wien, Österreich

    Wolfgang R. Mayr

  4. Essen, Germany

    J. Bertrams  & H. Grosse-Wilde  & 

  5. Ulm, Germany

    S. Goldmann

  6. Heidelberg, Germany

    G. Opelz

  7. Bonn, Germany

    C. Rittner

  8. Munich, Germany

    D. J. Schendel , S. Scholz  & R. Wank ,  & 

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© 1984 Springer-Verlag Berlin Heidelberg

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Cite this paper

Bodmer, J.G. et al. (1984). HLA-D Region Monoclonal Antibodies. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_92

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  • DOI: https://doi.org/10.1007/978-3-642-69770-8_92

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69772-2

  • Online ISBN: 978-3-642-69770-8

  • eBook Packages: Springer Book Archive

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