Abstract
DQw2 (MB2) was originally defined in 1979 by a cluster of five Seventh Workshop B-cell antisera as a new HLA-D region antigen associated with DR3 and DR7 [1], This determinant is similar to Te24 [2] and DC3 [3]. During the Eighth Workshop, DQw2 could be defined by a serum cluster with high correlation values [4]. However, most sera in this cluster also contained DR7 antibodies, making DQw2 assignment on DR7 cells more difficult. Although DQw2 has been suggested to present a cross-reacting group of DR3 + DR7 antigens, recent biochemical data from different laboratories have demonstrated that DQw2 resides on class II molecules different from DR molecules and perhaps equivalent to the murine I-A molecules [5, 6]. This would suggest that DQw2 may be controlled by a distinct HLA-D gene. Disease association studies have shown strong associations of DQw2 with celiac disease and dermatitis herpetiformis.
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© 1984 Springer-Verlag Berlin Heidelberg
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Marrari, M., Duquesnoy, R.J. (1984). Antigen Report: HLA-DQw2. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_89
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DOI: https://doi.org/10.1007/978-3-642-69770-8_89
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