Antigen Report: HLA-DRw8

Abstract

The definition of DRw8 at the last Histocompatibility Workshop was based on the reactions of five sera with r values between 0.40 and 0.58 [1]. For this Workshop, analysis of DRw8 was studied in relation to DR5 and DRw6. More extensive serum reaction patterns are presented in all three reports to permit a better comparison of these cross-reacting specificities (Table 1). The segregation pattern of the sera shown in Table 1 were studied in informative Workshop families. The mode of selection is given in details in the Joint Reports on DR5 (Bétuel et al., this volume) and on DRw6 (Schreuder et al., this volume). Examples of such haplotypes are presented in Table 2. Several DRw8-related patterns were observed in which all DRw52 (MT2), DR5 + w8 + w13 (6.6) and DRw8 sera were positive.