Restriction of Human Influenza A Virus-Specific T Cell Clones by HTC-Defined Subtypes of HLA-Dw6
Human antigen-specific proliferative T lymphocyte clones (TLCs) generally recognize nominal antigen in association with self class II MHC molecules on the antigen-presenting cell (APC). Alloantisera against HLA-DR antigens could inhibit antigen recognition, and studies using panels of APCs have shown that the restriction elements (REs) for the recognition of antigen were strongly correlated with HLA-DR/D antigens . The use of cloned lines of antigen-specific TLCs has suggested that several class II HLA-antigens can act as REs for antigen recognition by T cells [2, 3]. However, the question is still open of whether the HLA determinants activating alloreactive T cell responses are recognized as REs by self-restricted antigen-specific TLCs. In this report we demonstrate a close relationship between the REs for influenza virus-specific TLCs and the allodeterminants defined by HTCs.
KeywordsChlamydia Trachomatis Restriction Element Lymphocyte Clone Autologous APCs Suppressor Cell Induction
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