Restriction of Human Influenza A Virus-Specific T Cell Clones by HTC-Defined Subtypes of HLA-Dw6

  • B. Fleischer
  • M. Blaurock
  • P. Wernet
  • G. Pawelec
Conference paper

Abstract

Human antigen-specific proliferative T lymphocyte clones (TLCs) generally recognize nominal antigen in association with self class II MHC molecules on the antigen-presenting cell (APC). Alloantisera against HLA-DR antigens could inhibit antigen recognition, and studies using panels of APCs have shown that the restriction elements (REs) for the recognition of antigen were strongly correlated with HLA-DR/D antigens [1]. The use of cloned lines of antigen-specific TLCs has suggested that several class II HLA-antigens can act as REs for antigen recognition by T cells [2, 3]. However, the question is still open of whether the HLA determinants activating alloreactive T cell responses are recognized as REs by self-restricted antigen-specific TLCs. In this report we demonstrate a close relationship between the REs for influenza virus-specific TLCs and the allodeterminants defined by HTCs.

Keywords

Influenza Nylon Tetanus Ferrone 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • B. Fleischer
    • 1
  • M. Blaurock
    • 2
  • P. Wernet
    • 2
  • G. Pawelec
    • 2
  1. 1.Department of ImmunologyUniversität UlmUlmFederal Republic of Germany
  2. 2.Immunology LaboratoryMedizinische KlinikTübingenFederal Republic of Germany

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