Structural Polymorphism in DQw3 Light Chains

  • Naoshi Ishikawa
  • M. Kasahara
  • H. Ikeda
  • K. Ogasawara
  • S. Hawkin
  • T. Takenouchi
  • A. Wakisaka
  • I. Kikuchi
  • M. Aizawa

Abstract

The DQ alloantigen system, originally described by Duquesnoy et al. [1], encodes three distinctive allelic antigens that are closely associated with particular HLA-DR antigens. Although the molecular relationship between DQ and DR antigens has long been a matter of controversy because of extremely strong linkage disequilibria between DQ and DR loci, recent biochemical evidence unequivocally shows that DQ antigens are molecularly separate from DR [2] and that they represent the human homologues of murine I-A antigens [3], whereas DR antigens are the human counterparts of murine I-E antigens [4].

Keywords

Electrophoresis Polypeptide Dodecyl Tated Allo 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • Naoshi Ishikawa
    • 1
  • M. Kasahara
  • H. Ikeda
  • K. Ogasawara
  • S. Hawkin
  • T. Takenouchi
  • A. Wakisaka
  • I. Kikuchi
  • M. Aizawa
  1. 1.Department of PathologyHokkaido University School of MedicineSapporoJapan

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