Structural Polymorphism in DQw3 Light Chains
The DQ alloantigen system, originally described by Duquesnoy et al. , encodes three distinctive allelic antigens that are closely associated with particular HLA-DR antigens. Although the molecular relationship between DQ and DR antigens has long been a matter of controversy because of extremely strong linkage disequilibria between DQ and DR loci, recent biochemical evidence unequivocally shows that DQ antigens are molecularly separate from DR  and that they represent the human homologues of murine I-A antigens , whereas DR antigens are the human counterparts of murine I-E antigens .
KeywordsStructural Polymorphism Chain Subunit Serologic Specificity Light Chain Subunit Homozygous Typing Cell
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