Private Specificities of Human IA-Like Molecules Detected by T Cell Lines
Among a number of human T cell lines tested, two alloreactive and two GAT-specific, HLA-restricted lines were found to be inhibited by monoclonal antibodies against human IA-like (DQ) molecules. When tested in panel studies, the specificities detected were distinct from any known HLA antigens, but were associated with DR and DQ antigens. This indicates that, in addition to the “supertypic” or public specificities, the human IA-like molecules carry private specificities recognized by T cells.
KeywordsChronic Lymphocytic Leukemia Panel Study Responder Cell Panel Cell Cell Subline