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Anti-Idiotypic Antibodies in Women with Successful Pregnancy

  • D. P. Singal
  • L. Butler
  • S.-K. Liao
  • S. Joseph
Conference paper

Abstract

We have recently shown that anti-idiotypic antibodies capable of inhibiting responses in MLC and CML can be induced by transplantation and transfusion [1–3]. Based on these observations, we reasoned that such antibodies may also be induced in women alloimmunized by pregnancy. To test this hypothesis, we tested sera from women for anti-idiotypic antibodies directed against husband- specific idiotypes on wife’s lymphocytes.

Keywords

Parous Woman Multiparous Woman Autologous Serum Responder Cell Mixed Leukocyte Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Nagarkatti PS, Singal DP (1983) Blood-transfusion-induced suppression of cytotoxic T lymphocyte responses in mice. Transplantation 36: 520–525PubMedCrossRefGoogle Scholar
  2. 2.
    Nagarkatti PS, Joseph S, Singal DP (1983) Induction of antibodies by blood transfusions capable of inhibiting responses in MLC. Transplantation 36: 695–699PubMedCrossRefGoogle Scholar
  3. 3.
    Singal DP, Joseph S (1982) Role of blood transfusions on the induction of antibodies directed against recognition sites on T lymphocytes in renal transplant patients. Hum Immunol 4: 93–108PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • D. P. Singal
    • 1
  • L. Butler
    • 1
  • S.-K. Liao
    • 1
  • S. Joseph
    • 1
  1. 1.Department of PathologyMcMaster University HamiltonCanada

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