We have recently shown that anti-idiotypic antibodies capable of inhibiting responses in MLC and CML can be induced by transplantation and transfusion [1–3]. Based on these observations, we reasoned that such antibodies may also be induced in women alloimmunized by pregnancy. To test this hypothesis, we tested sera from women for anti-idiotypic antibodies directed against husband- specific idiotypes on wife’s lymphocytes.
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