Anti-Idiotypic Antibodies in Women with Successful Pregnancy

  • D. P. Singal
  • L. Butler
  • S.-K. Liao
  • S. Joseph
Conference paper

Abstract

We have recently shown that anti-idiotypic antibodies capable of inhibiting responses in MLC and CML can be induced by transplantation and transfusion [1–3]. Based on these observations, we reasoned that such antibodies may also be induced in women alloimmunized by pregnancy. To test this hypothesis, we tested sera from women for anti-idiotypic antibodies directed against husband- specific idiotypes on wife’s lymphocytes.

Keywords

Sera 

References

  1. 1.
    Nagarkatti PS, Singal DP (1983) Blood-transfusion-induced suppression of cytotoxic T lymphocyte responses in mice. Transplantation 36: 520–525PubMedCrossRefGoogle Scholar
  2. 2.
    Nagarkatti PS, Joseph S, Singal DP (1983) Induction of antibodies by blood transfusions capable of inhibiting responses in MLC. Transplantation 36: 695–699PubMedCrossRefGoogle Scholar
  3. 3.
    Singal DP, Joseph S (1982) Role of blood transfusions on the induction of antibodies directed against recognition sites on T lymphocytes in renal transplant patients. Hum Immunol 4: 93–108PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • D. P. Singal
    • 1
  • L. Butler
    • 1
  • S.-K. Liao
    • 1
  • S. Joseph
    • 1
  1. 1.Department of PathologyMcMaster University HamiltonCanada

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