The Second Complement Component, C2, in the Ninth Workshop
Since the invention of the hemolytic overlay technique to reveal the presence of C2 in gels after isoelectric focusing [1, 4, 5], studies have been made in several populations [reviewed in 6], initially in Caucasoids and latterly in Mongoloids. In all groups studied, polymorphism of C2 has been shown. In Caucasoids there is one common allele, C2*l, which accounts for some 96% of C2 genes, and a less common allele, C2*2 (or C2*B), which accounts for about 4%. There are then a few much rarer variants.
KeywordsComplement Region Founder Haplotype Human Major Histocompatibility Complex Class Complete Haplotype Diabetes Research Institute
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