Abstract
In addition to the amino acid requirement for protein synthesis, all animals need an extra supply to replace irreversible amino acid losses by gluconeogenesis and other ongoing, oxidative and biosynthetic reactions. During intestinal absorption, this need is met by the breakdown of ingested proteins, but when absorption ceases, internal sources must be called into play. Because free amino acids are not stored in mammalian cells or extracellular spaces to any significant extent, this supply (or its nitrogen equivalent) can only come from the degradation of endogenous proteins.
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Mortimore, G.E., Pösö, A.R. (1984). Mechanism and Control of Deprivation-Induced Protein Degradation in Liver: Role of Glucogenic Amino Acids. In: Häussinger, D., Sies, H. (eds) Glutamine Metabolism in Mammalian Tissues. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69754-8_9
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DOI: https://doi.org/10.1007/978-3-642-69754-8_9
Publisher Name: Springer, Berlin, Heidelberg
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