Contractile Function of the Ischemic Myocardium
Almost 50 years have passed since Tennant and Wiggers established that coronary occlusion rapidly resulted in a loss of myocardial systolic shortening distal to the occlusion. Since then, many more works have been done to elucidate the electrophysiological, biochemical or mechanical changes attending ischemia, to assess their reversibility and to determine pharmacological meants to prevent or correct some consequences of ischemia. The problem is however very complex and many questions remain unsettled. The purpose of this review is to summarize recent findings to the contractile function during ischemia and to evaluate their implications in patients with ischemic heart disease.
KeywordsIschemia Lactate Alanine Catecholamine Propranolol
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