Expression of Cellular Oncogenes

  • R. Müller
  • I. M. Verma
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 112)


Acutely oncogenic retroviruses induce a broad spectrum of malignant tumors (for review see Graf and Beug 1978; Teich et al. 1982). They all contain genomic sequences that are responsible for the induction of neoplastic transformation in vivo and in vitro. These sequences, termed viral oncogenes (v-onc), originated from the normal cellular genome (Bishop and Varmus 1982). Cellular homologs (c-one) of 20 different retroviral oncogenes have now been identified in a variety of species throughout the vertebrate phylum (Table 1) (Stehelin et al. 1976; Bishop and Varmus 1982; Bishop 1983), and in some instances even in invertebrates (Shilo and Weinberg 1982). Another category of c-one genes has been detected in the DNA of malignant cells by virtue of these genes’ ability to induce neoplastic transformation when “transfected” into a mouse fibroblastic cell line in vitro (for review see Cooper 1982). In several cases, however, it has been shown that such sequences are in fact the cellular homologs of v-onc genes (Der et al. 1982; Parada et al. 1982; Santos et al. 1982; McCoy et al. 1983; Shimizu et al. 1983c).


Rous Sarcoma Virus Avian Myeloblastosis Virus Cellular Oncogene Avian Sarcoma Virus Murine Sarcoma Virus 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • R. Müller
    • 1
  • I. M. Verma
    • 2
  1. 1.European Molecular Biology LaboratoryHeidelbergGermany
  2. 2.Molecular Biology and Virology LaboratoryThe Salk InstituteSan DiegoUSA

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