The Genetics of Murine Leukemia Viruses

  • S. P. Goff
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 112)


The murine leukemia viruses are prototypical replication-competent retroviruses. These viruses were among the first known oncogenic agents in mammals and have been the subjects of intensive study for more than 3 decades (Gross 1970). We now have a detailed understanding of the life cycle of these viruses and of some of the genetic effects they can have on the host cell; we are even beginning to discover how these viruses cause leukemia. Today, these viruses remain popular systems for the study of gene transfer and expression, site-specific recombination in mammalian cells, mutagenesis, and the processes of induction and progression of tumors. Most recently, their similarity to the human T-cell leukemia viruses (HTLVs) (Poiesz et al. 1982) and to sequences endogenous to the human genome (Repaske et al. 1983) has stimulated interest in a still larger scientific community.


Leukemia Virus Murine Leukemia Virus Rous Sarcoma Virus Nonpermissive Temperature Ecotropic Murine Leukemia Virus 
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© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • S. P. Goff
    • 1
  1. 1.Department of Biochemistry and Institute for Cancer ResearchColumbia University, College of Physicians and SurgeonsNew YorkUSA

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