The Genetics of Murine Leukemia Viruses
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The murine leukemia viruses are prototypical replication-competent retroviruses. These viruses were among the first known oncogenic agents in mammals and have been the subjects of intensive study for more than 3 decades (Gross 1970). We now have a detailed understanding of the life cycle of these viruses and of some of the genetic effects they can have on the host cell; we are even beginning to discover how these viruses cause leukemia. Today, these viruses remain popular systems for the study of gene transfer and expression, site-specific recombination in mammalian cells, mutagenesis, and the processes of induction and progression of tumors. Most recently, their similarity to the human T-cell leukemia viruses (HTLVs) (Poiesz et al. 1982) and to sequences endogenous to the human genome (Repaske et al. 1983) has stimulated interest in a still larger scientific community.
KeywordsLeukemia Virus Murine Leukemia Virus Rous Sarcoma Virus Nonpermissive Temperature Ecotropic Murine Leukemia Virus
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