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The Genetics of Murine Leukemia Viruses

  • S. P. Goff
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 112)

Abstract

The murine leukemia viruses are prototypical replication-competent retroviruses. These viruses were among the first known oncogenic agents in mammals and have been the subjects of intensive study for more than 3 decades (Gross 1970). We now have a detailed understanding of the life cycle of these viruses and of some of the genetic effects they can have on the host cell; we are even beginning to discover how these viruses cause leukemia. Today, these viruses remain popular systems for the study of gene transfer and expression, site-specific recombination in mammalian cells, mutagenesis, and the processes of induction and progression of tumors. Most recently, their similarity to the human T-cell leukemia viruses (HTLVs) (Poiesz et al. 1982) and to sequences endogenous to the human genome (Repaske et al. 1983) has stimulated interest in a still larger scientific community.

Keywords

Leukemia Virus Murine Leukemia Virus Rous Sarcoma Virus Nonpermissive Temperature Ecotropic Murine Leukemia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • S. P. Goff
    • 1
  1. 1.Department of Biochemistry and Institute for Cancer ResearchColumbia University, College of Physicians and SurgeonsNew YorkUSA

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