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Bovine Leukemia Virus

  • J. Ghysdael
  • C. Bruck
  • R. Kettmann
  • A. Burny
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 112)

Abstract

The most common neoplasm of the bovine species is, by far, lymphoid leukosis. Two classes of bovine leukosis have been distinguished on the basis of their pathology and seroepidemiology. Sporadic bovine leukosis (SBL) is observed throughout the world as solitary cases within a herd. It is a noncontagious disease with no known viral etiology. Lymphoid tumors, multicentric, cutaneous, or thymic, are generally observed in young animals (4 months to 1 year old) and tumor cells appear to be of non-B-cell lineage. Enzootic bovine leukosis (EBL) is a highly contagious disease induced by a retrovirus exogenous to the bovine species, bovine leukemia virus (BLV). It is a chronic disease, evolving over extended periods (1–8 years), with tumors developing in only a small number of infected animals.

Keywords

Long Terminal Repeat Natl Cancer Inst Bovine Leukemia Virus Bovine Leukemia Virus Infection Persistent Lymphocytosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson LJ, Jarrett WFH, Crighton GW (1968) A classification of lymphoid neoplasms of domestic animals. Natl Cancer Inst Monogr 32:343–353Google Scholar
  2. Baliga V, Ferrer J (1977) Expression of the bovine leukemia virus and its internal antigen in blood lymphocytes. Proc Soc Exp Biol Med 156:388–391PubMedGoogle Scholar
  3. Baumgartener LE, Olson C (1982) Host range of bovine leukosis virus: preliminary report. Curr Top Vet Med Anim Sci 15:338–347Google Scholar
  4. Baumgartener L, Olson C, Onuma M (1976) Effect of pasteurization and heat treatment on bovine leukemia virus. J Am Vet Med Assoc 169:1189–1191PubMedGoogle Scholar
  5. Bech-Nielsen S, Piper CE, Ferrer JF (1978) Natural mode of transmission of the bovine leukemia virus: role of blood-sucking insects. J Am Vet Med Assoc 39:1089–1092Google Scholar
  6. Benton CV, Soria AE, Gilden RV (1978) Direct syncytial assay for the quantitation of bovine leukemia virus. Infect Immun 20:307–309PubMedGoogle Scholar
  7. Bruck C, Mathot S, Portetelle D, Berte C, Franssen JD, Herion P, Burny A (1982a) Monoclonal antibodies define eight independent antigenic regions on the bovine leukemia virus (BLV) envelope glycoprotein gp51. Virology 122:342–352PubMedGoogle Scholar
  8. Brack C, Portetelle D, Burny A, Zavada J (1982b) Topographical analysis by monoclonal antibodies of BLV gp51 epitopes involved in viral functions. Virology 122:353–362Google Scholar
  9. Brack C, Rensonnet N, Portetelle D, Cleuter Y, Mammerickx M, Burny A, Mamoun R, Guillemain B, Van der Maaten M, Ghysdael J (1984) Biologically active epitopes of Bovine leukemia virus glycoprotein gp51 : their dependence on protein glycosylation and genetic variability. Virology, in pressGoogle Scholar
  10. Burki F (1982) Experiences and progress achieved with BLV elimination from Austrian livestock. Curr Top Vet Med Anim Sci 15:516–527Google Scholar
  11. Burny A, Bex F, Chantrenne H, Cleuter Y, Dekegel D, Ghysdael J, Kettmann R, Leclercq M, Leunen J, Mammerickx M, Portetelle D (1978 a) Bovine leukemia virus involvement in enzootic bovine leukosis. Adv Cancer Res 28:251–311PubMedGoogle Scholar
  12. Burny A, Bex F, Brack C, Cleuter Y, Dekegel D, Ghysdael J, Kettmann R, Leclercq M, Mammerickx M, Portetelle D (1978 b) Biochemical studies on enzootic and sporadic types of bovine leukosis. In: Chandra P (ed) Antiviral mechanisms in the control of neoplasia. Plenum, New York, pp 83–99Google Scholar
  13. Burny A, Brack C, Chantrenne H, Cleuter Y, Dekegel D, Ghysdael J, Kettmann R, Leclercq M, Leunen J, Mammerickx M, Portetelle D (1980) Bovine leukemia virus: molecular biology and epidemiology. In: Klein G (ed) Viral oncology. Raven, New York, pp 231–289Google Scholar
  14. Burridge MJ, Thurmond MC, Puhr DM, Wilcox CJ, Simerl NA (1982) Preliminary studies on impact of bovine leukemia virus infection on dairy productivity. Curr Top Vet Med Anim Sci 15:599–603Google Scholar
  15. Callahan R, Lieber MM, Todaro GJ, Graves DC, Ferrer JF (1976) Bovine leukemia virus genes in the DNA of leukemic cattle. Science 192:1005–1007PubMedGoogle Scholar
  16. Casey JW, Nicolson MO (1982) Susceptibility to productive infection by the bovine leukemia virus is governed at the proviral level. Fed Proc 41 (3): 1275Google Scholar
  17. Coffin JM, Varmus HE, Bishop JM, Essex M, Hardy WD, Martin GS, Rosenberg NE, Scolnick EM, Weinberg RA, Vogt PK (1981) Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol 40:953–957PubMedGoogle Scholar
  18. Copeland TD, Morgan MA, Oroszlan S (1983) Submitted for publicationGoogle Scholar
  19. Cornefert-Jensen F, Hare WC, Stock ND (1969) Studies on bovine lymphosarcoma. Formation of syncytia and detection of virus particles in mixed cell cultures. Int J Cancer 4:507–519PubMedGoogle Scholar
  20. Couez D, Deschamps J, Kettmann R, Stephens RM, Gilden RW, Burny A (1984) Nucleotide sequence analysis of the long terminal repeat of integrated bovine leukemia virus DNA and adjacent viral and host sequences. J Virol 49:615–620PubMedGoogle Scholar
  21. Deschamps J, Kettmann R, Burny A (1981) Experiments with cloned complete tumor-derived bovine leukemia virus information prove that the virus is totally exogenous to its target animal species. J Virol 40:605–609PubMedGoogle Scholar
  22. Devare SG, Chander S, Samagh BS, Stephenson JR (1977) Evaluation of radioimmunoprecipitation for the detection of bovine leukemia virus infection in domestic cattle. J Immunol 119:277–282PubMedGoogle Scholar
  23. Devare SG, Oroszlan S, Stephenson JR (1978) Application of radioimmunologic techniques to epidemiologic studies of lymphosarcoma in domestic cattle. Ann Rech Vet 9:689–697PubMedGoogle Scholar
  24. Devare SG, Stephenson JR, Sarma PS, Aaronson SA, Chander S (1976) Bovine lymphosarcoma: development of a radioimmunologic technique for detection of the etiologic agents. Science 194:1428–1430PubMedGoogle Scholar
  25. De Vries G (1982) Progress and problems in the eradication of EBL in the Netherlands. Cun- Top Vet Med Anim Sci 15:510–513Google Scholar
  26. Diglio CA, Ferrer JF (1976) Induction of syncytia by the bovine C-type leukemia virus. Cancer Res 36:1056–1067PubMedGoogle Scholar
  27. Drescher B, Rössler H, Venker P, Wittmann W (1979) Purification and characterization of bovine leukemia virus DNA polymerase. Arch Geschwulstforsch 49:569–579PubMedGoogle Scholar
  28. Driscoll DM, Olson C (1977) Bovine leukemia virus associated antigens in lymphocyte cultures. Am J Vet Res 38:1897–1898PubMedGoogle Scholar
  29. Ferrer J (1982) Use of the radioimmunoassay in a program aimed at the evadication of bovine leukemia virus (BLV) infection from a high incidence herd. Curr Top Vet Med Anim Sci 15:532–542Google Scholar
  30. Ferrer JF, Diglio CA (1976) Development of an in vitro infectivity assay for the C-type bovine leukemia virus. Cancer Res 36:1068–1073PubMedGoogle Scholar
  31. Ferrer JF, Stock ND, Lin PS (1971) Detection of replicating C-type viruses in continuous cell cultures established from cows with leukemia: effect of the culture medium. J Natl Cancer Inst 47:613–621PubMedGoogle Scholar
  32. Ferrer JF, Piper CE, Baliga V (1977) Diagnosis of BLV infection in cattle of various ages. In: Burny A (ed) Bovine leucosis : various methods of molecular virology. Comm Eur Communities, Luxembourg, pp 326–336Google Scholar
  33. Fujimoto Y, Miller J, Olson C (1969) The fine structure of lymphosarcoma in cattle. Pathol Vet 6:15–29PubMedGoogle Scholar
  34. Gerard-Marchand R, Hamlin I, Lennert K, Rilke F, Stanfeld AG, Van Unnik JAM (1974) Classification of non-Hodgkin’s lymphomas. Lancet ii : 406–408Google Scholar
  35. Ghysdael J, Kettmann R, Burny A (1978) Translation of bovine leukemia virus genome information in heterologous protein synthesizing systems programmed with virion RNA and in cell-lines persistently infected by BLV. Ann Rech Vet 9:627–634PubMedGoogle Scholar
  36. Ghysdael J, Kettmann R, Burny A (1979) Translation of BLV virion RNAs in heterologous protein synthesizing systems. J Virol 29:1087–1098PubMedGoogle Scholar
  37. Gilden RV, Long CW, Hanson M, Toni R, Charman HP, Oroszlan S, Miller JM, Van der Maaten MJ (1975) Characteristics of the major internal protein and DNA-dependent DNA polymerase of bovine leukemia virus. J Gen Virol 29:305–314PubMedGoogle Scholar
  38. Graves DC, Ferrer JF (1976) In vitro transmission and propagation of the bovine leukemia virus in monolayer cell cultures. Cancer Res 36:4152–4159PubMedGoogle Scholar
  39. Graves DC, Jones LV (1981) Early syncytium formation by bovine leukemia virus. J Virol 38:1055–1063PubMedGoogle Scholar
  40. Graves DC, Diglio CA, Ferrer JF (1977) A reverse transcriptase assay for detection of bovine leukemia virus. Am J Vet Res 38:1739–1744PubMedGoogle Scholar
  41. Guillemain B, Mamoun R, Levy D, Irgens K, Astier T, Parodi AL (1977) A quantitative study of early polykaryocytosis in mixed cultures of bovine leukemia virus infected bovine cells and mouse sarcoma virus infected cat cells. In: Burny A (ed) Bovine leucosis: various methods of molecular virology. Commission of the European Communities, Luxembourg, pp 347–356Google Scholar
  42. Gupta P, Ferrer JF (1982) Expression of bovine leukemia virus genome is blocked by a non-immunoglobulin protein in plasma from infected cattle. Science 215:405–407PubMedGoogle Scholar
  43. Hare WCD, Yang TJ, McFeely RA (1967) A survey of chromosome findings in 47 cases of bovine lymphosarcoma (leukemia), J Natl Cancer Inst 38:383–387PubMedGoogle Scholar
  44. Hayward WS, Neel BG, Astrin SM (1981) Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290:475–480PubMedGoogle Scholar
  45. Heuertz S, Hors-Cayla MC (1981) Cattle gene mapping by somatic cell hybridization study of 17 enzyme markers. Cytogenet Cell Genet 30:137–145PubMedGoogle Scholar
  46. Hinuma Y, Nagata K, Hanaoka M, Nakai N, Matsumoto T, Kinoshita K, Shirawa S, Miyoshi I (1981) Adult T cell leukemia: antigen in an ATL cell-line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 78:6476–6480PubMedGoogle Scholar
  47. Horvath Z (1982) Experimental transmission of bovine leukosis to sheep (Clinicopathological considerations). Curr Top Vet Med Anim Sci 15:269–281Google Scholar
  48. House JA, House C (1977) Studies on the bovine leukemia glycoprotein immunodiffusion test. In: Burny A (ed) Bovine leucosis : various methods of molecular virology. Commission of European Committees, Luxembourg, pp 237–246Google Scholar
  49. Huber NL, Digiacomo RF, Evermann JF, Studer E (1981) Bovine leukemia virus infection in a large holstein herd : prospective comparison of production and reproductive performance in antibody-negative and antibody-positive cows. Am J Vet Res 42:1477–1481PubMedGoogle Scholar
  50. Irgens K, Pinelli C, Guillemain B, Levy D, Parodi AL (1977) Early syntcytia formation induced by BLV producing cells in mixed cultures. In: Burny A (ed) Bovine leucosis: various methods of molecular virology. Communities, Luxembourg, pp 311–322Google Scholar
  51. Jarrett WFH, Mackey LJ (1974) Bull WHO 50:1–142Google Scholar
  52. Kaaden OR, Frenzel B, Dietzschold B, Weiland F, Mussgay M (1977) Isolation of a pl5 polypeptide from bovine leukemia virus and detection of specific antibodies in leukemic cattle. Virology 77:501–509PubMedGoogle Scholar
  53. Kaaden OR, Fischer W, Meerman A, Liebisch A (1982) Transmission of BLV by Ixodes ricinus ticks. Curr Top Vet Med Anim Sci 15:358–360Google Scholar
  54. Kashmiri SVS, Mehdi R, Ferrer JF (1983) Detection, purification and characterization of two species of covalently closed circular proviral DNA molecules of bovine leukemia virus. J Virol 45:1172–1176PubMedGoogle Scholar
  55. Kawakami TG, Moore AL, Theilen GH, Munn RJ (1970) Comparison of virus-like particles from leukotic cattle to feline leukosis virus. Bibl Haematol 36:471–475PubMedGoogle Scholar
  56. Kenyon SJ, Piper CE (1977) Properties of density gradient-fractionated peripheral blood leukocytes from cattle infected with bovine leukemia virus. Infect Immun 16:898–903PubMedGoogle Scholar
  57. Kenyon SJ, Gupta P, Ferrer JF (1982) Presence of the bovine leukemia virus (BLV) in milk of naturally infected cows. Curr Top Vet Med Anim Sci 15:289–297Google Scholar
  58. Kettmann R, Portetelle D, Mammerickx M, Cleuter Y, Dekegel D, Galoux M, Ghysdael J, Burny A, Chantrenne H (1976) Bovine leukemia virus: an exogenous RNA oncogenic virus. Proc Natl Acad Sci USA 73:1014–1018PubMedGoogle Scholar
  59. Kettmann R, Burny A, Cleuter Y, Ghysdael J, Mammerickx M (1978) Distribution of bovine leukemia virus proviral DNA sequences in tissues of animals with enzootic bovine leucosis. Leukemia Res 2:23–32Google Scholar
  60. Kettmann R, Cleuter Y, Mammerickx M, Meunier-Rotival M, Bernardi G, Burny A, Chantrenne H (1980 a) Genomic integration of bovine leukemia provirus: comparison of persistent lymphocytosis with lymph node tumor form of enzootic bovine leukosis. Proc Natl Acad Sci USA 77:2577–2581PubMedGoogle Scholar
  61. Kettmann R, Marbaix G, Cleuter Y, Portetelle D, Mammerickx M, Burny A (1980b) Genomic integration of bovine leukemia provirus and lack of viral RNA expression in the target cells of cattle with different responses to BLV infection. Leukemia Res 4:509–519Google Scholar
  62. Kettmann R, Deschamps J, Cleuter Y, Couez D, Burny A, Marbaix G (1982) Leukemogenesis by bovine leukemia virus: proviral DNA integration and lack of RNA expression of viral long terminal repeat and 3´ proximate cellular sequences. Proc Natl Acad Sci USA 79:2465–2469PubMedGoogle Scholar
  63. Kettmann R, Westin EH, Marbaix G, Deschamps J, Wong-Staal F, Gallo RC, Burny A (1983 a) Lack of expression of cellular homologues of retroviral onc genes in bovine tumors. In: Neth R et al (ed) Modern trends in human leukemia V. Springer, Berlin Heidelberg New York, pp 218–221Google Scholar
  64. Kettmann R, Deschamps J, Couez D, Claustriaux JJ, Palm R, Burny A (1983 b) J Virol 47:146–150PubMedGoogle Scholar
  65. Kumar SP, Paul PS, Pomeroy KA, Johnson DW, Muscoplat CC, Van der Maaten MJ, Miller JM, Sorensen DK (1978) Frequency of lymphocytes bearing Fc receptors and surface immunoglobulins in normal persistent lymphocytotic and leukemic cows. Am J Vet Res 39:45–49PubMedGoogle Scholar
  66. Langston A, Ferdinand GA, Ruppanner R, Theilen GH, Drlica S, Behymer D (1978) Comparison of production variables of bovine leukemia virus antibody-negative and antibody-positive cows in two California dairy herds. Am J Vet Res 39:1093–1098PubMedGoogle Scholar
  67. Lennert K, Stein H, Kasserling E (1975) Cytological and functional criteria for the classification of malignant lymphomas. Br J Cancer 31 [suppl II]: 29–43Google Scholar
  68. Long CW, Henderson LE, Oroszlan S (1980) Isolation and characterization of low molecular-weight DNA binding proteins from retroviruses. Virology 104:491–496PubMedGoogle Scholar
  69. Maas-Inderwiesen F, Albrecht A, Bause I, Osmers M, Schmidt FW (1978) Zum Einfluß der Leukose- bekämpfung auf die Entwicklung der enzootischen Rinderleukose in Niedersachsen. Dtsch Tier- ärztl Wochenschr 85:309–314Google Scholar
  70. Mammerickx M (1972 a) Etude epizootologique sur les leucoses des animaux en Belgique de 1961 à 1970. Ann Med Vet 116:157–166Google Scholar
  71. Mammerickx M (1972 b) La transmission verticale et horizontale de la leucose bovine enzootique. Premiers résultats après cinq and d’expérimentation. Ann Med Vet 116:647–659Google Scholar
  72. Mammerickx M (1973) L’examen nécropsique des bovidés leucémiques. Ann Med Vet 117:93–102Google Scholar
  73. Mammerickx M, Cormann A, Burny A, Dekegel D, Portetelle D (1978) Eradication of enzootic bovine leukosis based on the detection of the disease by the gp51 immunodiffusion test. Ann Rech Vet 9:885–894PubMedGoogle Scholar
  74. Mammerickx M, Portetelle D, Burny A (1981) Experimental cross-transmissions of bovine leukemia virus (BLV) between several animal species. Zentralbl Veterinaermed (B) 28:69–81Google Scholar
  75. Mamoun RZ, Astier T, Guillemain B (1981) Establishment and propagation of a bovine leukemia virus-producing cell-line derived from the leukocytes of a leukemic cow. J Gen Virol 54:357–365PubMedGoogle Scholar
  76. Mamoun RZ, Astier T, Guillemain B, Duplan JF (1983) Bovine lymphosarcoma: expression of BLV-related proteins in cultured cells. J Gen Virol 64:1895–1905PubMedGoogle Scholar
  77. Marbaix G, Kettmann R, Cleuter Y, Burny A (1981) Viral RNA content of bovine leukemia virus-infected cells. Mol Biol Rep 7:135–138PubMedGoogle Scholar
  78. Marín C, López N, Lozano O, Palencia L, Espa\(\ddot{\text{n}}\)a W, Castaños H, León H (1978) Epidemiology of bovine leukemia in Venezuela. Ann Rech Vet 9:743–746PubMedGoogle Scholar
  79. Marín C, de Lopez N, de Alvarez M, Castaños H, Espa\(\ddot{\text{n}}\)a W, León A, Bello A (1982) Humoral spontaneous response to bovine leukaemia virus infection in zebu, sheep, buffalo and capybara. Curr Top Vet Med Anim Sci 15:310–320Google Scholar
  80. McDonald HC, Ferrer JF (1976) Detection, quantitation and characterization of the major internal virion antigen of the bovine leukemia virus by radioimmunoassay. J Natl Cancer Inst 57:875–882PubMedGoogle Scholar
  81. Miller JM, Olson C (1972) Precipitating antibody to an internal antigen of the C-type virus associated with bovine lymphosarcoma. J Natl Cancer Inst 49:1459–1462PubMedGoogle Scholar
  82. Miller JM, Van der Maaten JM (1978 a) Evaluation of an inactivated bovine leukemia virus preparation as an immunogen in cattle. Ann Rech Vet 9:871–877PubMedGoogle Scholar
  83. Miller JM, Van der Maaten MJ (1978 b) Infectivity tests of secretions and excretions from cattle infected by bovine leukemia virus. J Natl Cancer Inst 62:425–428Google Scholar
  84. Miller JM, Miller LD, Olson C, Gillette KG (1969) Virus-like particles in phytohemagglutinin- stimulated lymphocyte culture with reference to bovine lymphosarcoma. J Natl Cancer Inst 43:1297–1305PubMedGoogle Scholar
  85. Miller JM, Van der Maaten MJ, Schmerr MJ (1983) Vaccination of cattle with binary ethylenimine- treated bovine leukemia virus. Am J Vet Res 44:64–67PubMedGoogle Scholar
  86. Muscoplat C, Johnson DW, Pomeroy KA, Olson JM, Larson VL, Stevens JB, Sorensen DK (1974) Lymphocyte surface immunoglobulin: frequency in normal and lymphocytotic cattle. Am J Vet Res 35:593–595Google Scholar
  87. Ogura H, Paulsen J, Bauer H (1977) Cross neutralization of ovine and bovine C-type leukemia virus-induced syncytia formation. Cancer Res 37:1486–1489PubMedGoogle Scholar
  88. Olson C, Kettmann R, Burny A, Kaja R (1981) Goat lymphosarcoma from bovine leukemia virus. J Natl Cancer Inst 67:671–675PubMedGoogle Scholar
  89. Onuma M, Olson C, Baumgartener LE, Pearson LD (1975) An ether-sensitive antigen associated with bovine leukemia virus infection. J Natl Cancer Inst 55:1155–1158PubMedGoogle Scholar
  90. Onuma M, Honma T, Mikami T, Ichijo S, Konishi T (1979) Studies on the sporadic and enzootic forms of bovine leukosis. J Comp Pathol 89:159–167PubMedGoogle Scholar
  91. Onuma M, Hodatsu T, Yamamoto S, Higashihara M, Masu S, Izawa H, Mikami T (1983) Protection against bovine leukemia virus infection in sheep by vaccination. Am J Vet Res, in pressGoogle Scholar
  92. Oroszlan S, Copeland TD, Henderson LE, Stephenson JR, Gilden RV (1979) Amino-terminal sequence of bovine leukemia virus major internal protein : homology with mammalian type-C virus p30 structural proteins. Proc Natl Acad Sci USA 76:2996–3000PubMedGoogle Scholar
  93. Oroszlan S, Sarngadharan MG, Copeland TD, Kalyanaraman VS, Gilden RV, Gallo RC (1982) Primary structure analysis of the major internal protein p24 of human type C T-cell leukemia virus. Proc Natl Acad Sci USA 79:1291–1294PubMedGoogle Scholar
  94. Parodi AL, Mialot M, Crespeau F, Levy D, Salmon H, Nogues G, Gerard-Marchand R (1982) Attempt for a new cytological and cytoimmunological classification of bovine malignant lymphoma (BML) (lymphosarcoma). Curr Top Vet Med Anim Sci 15:561–572Google Scholar
  95. Paul PS, Pomeroy KA, Castro AE, Johnson DW, Muscoplat CC, Sorensen DK (1977 a) Detection of bovine leukemia virus in B-lymphocytes by the syncytia induction assay. J Natl Cancer Inst 59:1269–1271PubMedGoogle Scholar
  96. Paul PS, Pomeroy KA, Johnson DW, Muscoplat CC, Handwerger BS, Soper FS, Sorensen DK (1977b) Evidence for the replication of bovine leukemia virus in the B-lymphocytes. Am J Vet Res 38:873–876PubMedGoogle Scholar
  97. Payne GS, Bishop JM, Varmus HE (1981) Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature 295:209–213Google Scholar
  98. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC (1980) Detection and isolation of type-C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77:7415–7419PubMedGoogle Scholar
  99. Poiesz BJ, Ruscetti FW, Reitz MS, Kalyanaraman VS, Gallo RC (1981) Isolation of a new type-C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukemia. Nature 294:268–271PubMedGoogle Scholar
  100. Portetelle D, Mammerickx M, Beck F, Burny A, Cleuter Y, Dekegel D, Ghysdael J, Kettmann R, Chantrenne H (1977) Purification of BLV gp70 and BLV p24. Detection by radioimmunoassay of antibodies directed against these antigens. In : Burny A (ed) Bovine leucosis : various methods of molecular virology. Commission of the European Communities, Luxembourg, pp 131–152Google Scholar
  101. Portetelle D, Brack C, Burny A, Dekegel D, Mammerickx M, Urbain J (1978) Detection of complement-dependent lytic antibodies in sera from bovine leukemia virus-infected animals. Ann Rech Vet 9:667–674PubMedGoogle Scholar
  102. Portetelle D, Brack C, Mammerickx M, Burny A (1980) In animals infected by bovine leukemia virus (BLV) antibodies to envelope glycoprotein gp51 are directed against the carbohydrate moiety. Virology 105:223–233PubMedGoogle Scholar
  103. Portetelle D, Brack C, Mammerickx M, Burny A (1983) Use of monoclonal antibody in an ELISA test for the detection of antibodies to bovine leukaemia virus. J Virol Meth 6:19–29Google Scholar
  104. Ressang AA, Mastenbroek N, Quak J, Van Griensven LJ, Calafat J, Hilgers J, Hageman P, Souissi T, Swen S (1974) Studies on bovine leukemia. I. Establishment of type-C virus producing cell lines. Zentralbl Veterinaermed (B) 21:602–617Google Scholar
  105. Schmerr MJ, Miller JM, Van der Maaten MJ (1981) Antigenic reactivity of a soluble glycoprotein associated with bovine leukemia virus. Virology 109:431–434PubMedGoogle Scholar
  106. Schmidt FW (1982) Results and observations of an EBL eradication program based on AGID diagnosis and culling of reactors. Curr Top Vet Med Anim Sci 15:491–497Google Scholar
  107. Seiki M, Hattori S, Yoshida M (1982) Human adult T-cell leukemia virus: molecular cloning of the provirus DNA and the unique terminal structures. Proc Natl Acad Sci USA 79:6899–6902PubMedGoogle Scholar
  108. Sentsui H, Thorn RM, Kono Y, Ferrer JF (1982) Haemagglutination by bovine leukaemia virus. J Gen Virol 59:83–89PubMedGoogle Scholar
  109. Stock ND, Ferrer JF (1972) Replicating C-type virus in phytohemagglutinin-treated buffy-coat cultures of bovine origin. J Natl Cancer Inst 48:985–996PubMedGoogle Scholar
  110. Straub O (1982) Transmission studies from leukemic cattle to sheep using secretions, excretions, breath and skin scrapings. Curr Top Vet Med Anim Sci 15:299–308Google Scholar
  111. Straub OC (1978) Preliminary results of a new sanitation program for the eradication of enzootic bovine leukosis. Ann Rech Vet 9:895–898PubMedGoogle Scholar
  112. Takashima I, Olson C, Driscoll DM, Baumgartener LE (1977) B- and T-lymphocytes in three types of bovine lymphosarcoma. J Natl Cancer Inst 59:1205–1209PubMedGoogle Scholar
  113. Theilen GH, Miller JM, Higgins J, Ruppaner RN, Garrett W (1982) Vaccination against bovine leukemia virus infection. Curr Top Vet Med Anim Sci 15:547–559Google Scholar
  114. Uckert W, Wunderlich V (1979) Proteins of bovine leukemia virus: p15 is the major phosphoprotein. Acta Biol Med Ger 38 : K42Google Scholar
  115. Uckert W, Wunderlich V, Ghysdael J, Portetelle D, Burny A (1984) Bovine leukemia virus (BLV - structural model based on chemical cross-linking studies. Virology, in pressGoogle Scholar
  116. Van der Maaten MJ, Miller JM (1976 a) Serological evidence of transmission of bovine leukemia virus to chimpanzees. Vet Microbiol 1:351–357Google Scholar
  117. Van der Maaten MJ, Miller JM (1976b) Replication of bovine leukemia virus in monolayer cell cultures. Bibl Haematol 43:360–362Google Scholar
  118. Van der Maaten MJ, Miller JM (1977) In: Cold Spring Harbor Lab (ed) Origins of human cancer. Cold Spring Harbor Laboratory, New York, pp 1223–1234Google Scholar
  119. Van der Maaten MJ, Miller JM, Boothe AD (1974) Replicating type-C virus particles in monolayer cell cultures of tissue from cattle with lymphosarcoma. J Natl Cancer Inst 52:491–494Google Scholar
  120. Weiland F, Straub OC (1975) Frequency of surface immunoglubulin-bearing blood lymphocytes in cattle affected with bovine leukosis. Res Vet Sci 19:100–102PubMedGoogle Scholar
  121. Wilesmith JW, Straub OC, Lorenz RJ (1978) Untersuchungen zur iatrogenen Übertragung des Virus der Rinderleukose. Tierärztl Umschau 33:519–523Google Scholar
  122. Wittmann W, Urbaneck D (1969) Leukosen des Rindes. In: Röhren H (ed) Handbuch der Virusinfektionen bei Tieren, vol V/1. Fischer, JenaGoogle Scholar
  123. Yoshikawa T, Yoshikawa H, Takeuchi S (1972) Bovine leukosis cluster in the Towada district of Japan. Kitasato Arch Exp Med 45:193–204PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • J. Ghysdael
    • 1
  • C. Bruck
    • 1
  • R. Kettmann
    • 2
  • A. Burny
    • 2
  1. 1.Laboratoire de Chimie BiologiqueUniversité Libre de BruxellesBrusselsBelgium
  2. 2.Faculté des Sciences Agronomiques de l’EtatGemblouxBelgium

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