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Microtubules pp 414-441 | Cite as

MT and MT Poisons in Pathology and Medicine

  • Pierre Dustin

Abstract

The highly conserved molecular structure of tubulin in evolution and the many essential functions of MT explain that tubulin mutations are probably often lethal. In Chapter 2, some abnormal tubulins have been mentioned, and some complexities of the genetics of α and β tubulin described. Apart from these variations of the tubulin molecule, there does not seem to be any pathological condition directly linked to abnormal tubulins. On the other hand, the tubulin-associated proteins, which are very numerous, and differ from cell to cell and from species to species, show a much larger variation, and could be the cause of anomalies of MT. This is particularly apparent in complex structures such a cilia and flagella, where many pathological conditions are known. There also may be some changes in the tubulin cytoskeleton of malignant cells, although this study has so far produced contradictory findings.

Keywords

Familial Mediterranean Fever Vinca Alkaloid Situs Inversus Colchicine Therapy Beige Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • Pierre Dustin
    • 1
  1. 1.Laboratoires d’Anatomie Pathologique et de Microscopie ElectroniqueUniversité Libre de BruxellesBruxellesBelgium

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