Laborit’s concept of “neuroplegia” was, perhaps, the first attempt to move away from total central nervous system depression by employing a combination of tranquilizing agents and narcotic analgesics for the selective inhibition of cellular, autonomic, and endocrine systems known to be activated in response to stress. Unfortunately, this drug-induced homeostatic imbalance frequently resulted in circulatory disturbances, which explains the reluctance of many physicians to accept this new concept of pain control during surgery.
- Emergence Delirium
- Halogenated Agent
- Entire Central Nervous System
- Dissociative Anesthesia
- Human Pharmacologic Study
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