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Radionuclide Methods

  • Chapter
Clinical Pharmacology of Antianginal Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 76))

Abstract

Radionuclide methods for testing antianginal drugs must fulfill the general prerequisites of evaluating coronary heart disease as well as special considerations of the particular method used:

  1. 1.

    Generally, they must allow performance at rest and under exercise under the same external conditions.

  2. 2.

    It should be possible to perform exercise in a supine as well as an upright position.

  3. 3.

    If radionuclide ventriculography is used, the time necessary for evaluation under exercise should be as short as possible. It is difficult to achieve a steady state of ischemia. If the “take” of the gamma camera necessary for a sufficiently high count rate is too long, there is the possibility that states of lesser and greater ischemia are mixed and yield a “diluted” result.

  4. 4.

    A critical condition for the design of the protocol is sufficient reproducibility, if the examination has to be repeated after such a length of time that patient and gamma camery have to be repositioned. For testing acute effects without moving cameray and patient, the reproducibility of technetium scintigraphy is usually sufficient.

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Authors
  1. W. E. Adam
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  2. M. Stauch
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Editor information

Editors and Affiliations

  1. Boehringer Mannheim GmbH, Sandhofer Straße 116, D-6800, Mannheim 31, Germany

    Ulrich Abshagen (Leiter Produktentwicklung Therapeutica) (Leiter Produktentwicklung Therapeutica)

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© 1985 Springer-Verlag Berlin Heidelberg

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Adam, W.E., Stauch, M. (1985). Radionuclide Methods. In: Abshagen, U. (eds) Clinical Pharmacology of Antianginal Drugs. Handbook of Experimental Pharmacology, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69524-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-69524-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69526-1

  • Online ISBN: 978-3-642-69524-7

  • eBook Packages: Springer Book Archive

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