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Contrast Media in the Cardiovascular System

  • C. B. Higgins
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 73)

Abstract

This chapter is a review of current knowledge of the cardiovascular effects of contrast media, examining the literature on this subject over the past 1½ decades. In the previous encyclopedia on radiocontrast agents [1], Almen comprehensively reviewed the published information dealing with the cardiovascular effects of contrast media up to the year 1968. As in other areas of biomedical research the output of scientific papers and new concepts on this subject in the past decade has approached, and on some topics surpassed, the total output prior to this time.

Keywords

Renal Blood Flow Coronary Blood Flow Coronary Arteriography Intracoronary Injection Meglumine Diatrizoate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Almen T (1971) Toxicity of radiocontrast agents. In: Knoefel PK (ed) Radiocontrast agents. Pergamon, Oxford, p 443 (International encyclopedia of pharmacology and therapeutics, vol 2)Google Scholar
  2. 2.
    Price HL (1960) General anesthesia and circulatory homeostasis. Physiol Rev 40:187PubMedGoogle Scholar
  3. 3.
    Peiss CN, Manning JW (1964) Effects of sodium pentobarbital on electrical and reflex activation of the cardiovascular system. Circ Res 14:228PubMedGoogle Scholar
  4. 4.
    Spann JR Jr, Mason DT, Beider GD, Gold HK (1969) Myocardial effects of angiographic dye (Abstr). Am J Cardiol 23:140CrossRefGoogle Scholar
  5. 5.
    Serur JR, Als AV, Miner-Green N, Paulin S (1980) Comparative effects of three radiographic contrast agents in isolated normal and ischemic canine hearts. Invest Radiol 15:5196CrossRefGoogle Scholar
  6. 6.
    Almen T, Aspelin P (1976) Cardiovascular effects of ionic, monomeric, ionic dimeric, and nonionic contrast media. Invest Radiol 10:557CrossRefGoogle Scholar
  7. 7.
    Als AV, Serur JR, LaRaia PJ, et al. (1978) Differential effects of sodium meglumine calcium metrizoate on the inotropic state of normal and ischemic myocardium. Radiology 128:499PubMedGoogle Scholar
  8. 8.
    Wolf GL, Gerlings ED, Wilson WJ (1973) Depression in myocardial contractility induced by hypertonic coronary injections in the isolated perfused dog heart. Radiology 107:655PubMedGoogle Scholar
  9. 9.
    Lipton MJ, Higgins CB, Wilea AAN, et al. (1978) The effect of contrast media on the isolated perfused canine heart. Invest Radiol 13:519PubMedCrossRefGoogle Scholar
  10. 10.
    Higgins CB, Schmidt W (1978) Alterations in calcium levels of coronary sinus blood during coronary arteriography in the dog. Circulation 58:512PubMedGoogle Scholar
  11. 11.
    Higgins CB, Schmidt W (1978) Direct and reflex myocardial effects of intracoronary administered contrast materials in the anesthetized and conscious dog: comparison of standard and newer contrast materials. Invest Radiol 13:205PubMedCrossRefGoogle Scholar
  12. 11a.
    Higgins CB, Bookstein JJ (1977) Comparative hemodynamic effects of coronary vasodilators and contrast material on the normal and ischemic canine myocardium. Determination of the optimal agent for clinical augmentation of coronary blood flow. Invest Radiol 12:299PubMedCrossRefGoogle Scholar
  13. 12.
    Newell JD, Schmidt W, Higgins CB (1979) Effects of intracoronary administration of contrast materials on left ventricular dimensions and rate of relaxation. Invest Radiol 14:233PubMedGoogle Scholar
  14. 13.
    Popio KA, Ross AM, Oravec JM, Ingram JT (1978) Identification and description of separate mechanisms for two components of Renografîn cardiotoxicity. Circulation 58:520PubMedGoogle Scholar
  15. 14.
    Braunwald E, Ross JJ, Sonnenblick EH (1976) Mechanisms of contraction of the normal and failing heart. Little, Brown, BostonGoogle Scholar
  16. 15.
    Mahler F, Ross JJ, O’Rourke RA, Covell JW (1975) Effects of changes in preload, afterload, and inotropic state on ejection and isovolumic phase measures of contractility in the dog. am J Cardiol 35:626PubMedCrossRefGoogle Scholar
  17. 16.
    Chahine RA, Raizner AE (1976) The mechanism of hypotension following angiography. Invest Radiol 11:472PubMedCrossRefGoogle Scholar
  18. 17.
    Higgins CB (1980) Overview and methods used for the study of the cardiovascular actions of contrast materials. Invest Radiol 15:S188PubMedCrossRefGoogle Scholar
  19. 18.
    Shaw DD, Wolf GL, Kraft L, Baltaxe HA (1977) The role of peripheral vasodilatation and direct myocardial depression in the systemic hypotensive response to ventriculography. Invest Radiol 12:424 (Abstr)Google Scholar
  20. 19.
    Freisinger GS, Schaefer J, Crilley JM, Gaertner RA, Ross RS (1965) Hemodynamic consequences of the injection of radiopaque material. Circulation 31:730Google Scholar
  21. 20.
    Hammermeister KE, Warbasse JR (1973) Immediate hemodynamic effects of cardiac angiography in man. Am J Cardiol 31:307PubMedCrossRefGoogle Scholar
  22. 21.
    Karliner JS, Bouchard RJ, Gault JH (1972) Hemodynamic effects of angiographic contrast material in man. Br Heart J 34:347PubMedCrossRefGoogle Scholar
  23. 22.
    Vine DL, Hegg TD, Dodge HT, Stewart DK, Frimer M (1977) Immediate effect of contrast medium injection on left ventricular volumes and ejection fraction. A study using metallic epicardial markers. Circulation 56:379PubMedGoogle Scholar
  24. 23.
    Baltaxe HA, Sos TA, McGrath MB (1976) Effects of the intracoronary and intraventricular injections of a commonly available vs. a newly available contrast medium. Invest Radiol 11:172PubMedCrossRefGoogle Scholar
  25. 24.
    Cohn PF, Horn HR, Teichholz LE, Kreuler TH, Herman MV, Jorlen R (1973) Effects of angiographic contrast medium on left ventricular function in coronary artery disease. Am J Cardiol 32:21PubMedCrossRefGoogle Scholar
  26. 25.
    Gootman N, Rudolph AM, Buckley NM (1970) Effects of angiographic contrast media on cardiac function. Am J Cardiol 25:59PubMedCrossRefGoogle Scholar
  27. 26.
    Mullins CB, Leshin SJ, Mierzwiak DS, Alsobrook HD, Mitchell JH (1972) Changes in left ventricular function produced by the injection of contrast media. Am Heart J 83:373PubMedCrossRefGoogle Scholar
  28. 27.
    Behar VS, Waxman WB, Morris JJ Jr (1970) The effects of a contrast medium (sodium iothalamate, 80%) on left ventricular function. Am J Med Sci 60:202PubMedCrossRefGoogle Scholar
  29. 28.
    Shaw DD, Wolf GL, Wilson WJ, Trevisani T (1975) The effect of angiotension II during ventriculography in dogs with normal coronary arteries. Radiology 115:717PubMedGoogle Scholar
  30. 29.
    Krovetz LJ, Mitchell BM, Neumaster T (1967) Hemodynamic effects of rapidly injected hypertonic solutions into the heart and great vessels. Am Heart J 74:453PubMedCrossRefGoogle Scholar
  31. 30.
    Kelley MJ, Higgins CB, Schmidt WS, Newell JD (1980) Effects of ionic and nonionic contrast agents on left ventricular and extracellular fluid dynamics during angiocardiography in an infant model. Invest Radiol 15:335PubMedCrossRefGoogle Scholar
  32. 31.
    Romero TE, Higgins CB, Kirkpatrick SE, Friedman WF (1977) Effects of contrast material on dimensions and hemodynamics of the newborn heart: a study in conscious newborn lambs. Invest Radiol 12:510PubMedCrossRefGoogle Scholar
  33. 32.
    Lindgren P, Tornell G (1958) Blood pressure and heart rate responses in carotid angiography with sodium acetrizoate. Acta Radiol (Stockh) 50:160PubMedCrossRefGoogle Scholar
  34. 33.
    Lynch PR, Harrington GJ, Michie C (1969) Cardiovascular reflexes associated with cerebral angiography. Invest Radiol 4:156PubMedCrossRefGoogle Scholar
  35. 34.
    Higgins CB, Schmidt W (1979) Identification and evaluation of the contribution of the chemoreflex in the hemodynamic response to intracarotid administration of contrast materials in the conscious dog: comparison with the response to nicotine. Invest Radiol 14:438PubMedCrossRefGoogle Scholar
  36. 35.
    Morris TW, Francis M, Fischer HW (1979) A comparison of the cardiovascular responses to carotid injections of ionic and nonionic contrast media. Invest Radiol 14:217PubMedGoogle Scholar
  37. 36.
    Vatner SF, Higgins CB, Franklin D, Braunwald E (1971) Extent of carotid sinus regulation of the myocardial contractile state in conscious dogs. J Clin Invest 50:1116CrossRefGoogle Scholar
  38. 37.
    Higgins CB, Vatner SF, Eckberg DL, Braunwald E (1972) Alterations in the barore-ceptor reflex in conscious dogs with heart failure. J Clin Invest 51:715PubMedCrossRefGoogle Scholar
  39. 38.
    Downing SE, Remensnyder PP, Mitchell JH (1962) Cardiovascular responses to hypoxic stimulation of the carotid bodies. Circ Res 10:676PubMedGoogle Scholar
  40. 39.
    Comroe JH Jr (1964) The peripheral chemoreceptors. In: Fenn W, Rahn H (eds) Respiration. American Physiological Society, Washington, D.C., p 557 (Handbook of physiology, vol 1)Google Scholar
  41. 40.
    Fischer HW (1968) Hemodynamic reactions to angiographic media. A survey and commentary. Radiology 91:66–73PubMedGoogle Scholar
  42. 41.
    Amundsen AK, Amundsen P, Muller O (1956) Blood pressure and heart rate during angiocardiography, abdominal aortography, and arteriography of the lower extremities. Acta Radiol (Stockh) 45:452PubMedCrossRefGoogle Scholar
  43. 42.
    DiDonato M, Bongrani S, Cucchini F, Baldi G, Fappani A, Colla B, Visioli O (1979) Cardiovascular effects induced by the injection of a new nonionic contrast medium (iopamidol): experimental study in dogs. Invest Radiol 143:309CrossRefGoogle Scholar
  44. 43.
    Berg GR, Hutter AM, Pfister RC (1973) Electrocardiographic abnormalities associated with intravenous urography. N Engl J Med 289:87PubMedCrossRefGoogle Scholar
  45. 44.
    Stanley RJ, Pfister RC (1976) Bradycardia and hypotension following use of intravenous contrast media. Radiology 121:5PubMedGoogle Scholar
  46. 45.
    Stadalnik RC, Vera Z, Da Silva O (1977) Electrocardiographic response to intravenous urography: prospective evaluation of 275 patients. AJR 129:825PubMedGoogle Scholar
  47. 46.
    White CW, Eckberg DL, Inasaka T, Abboud FM (1976) Effects of angiographic contrast media on sinoatrial nodal function. Cardiovasc Res 10:214PubMedCrossRefGoogle Scholar
  48. 47.
    Adams DF, Paulin S (1968) Effects of radiographic contrast media in selective injections into the sinus node artery. An experimental study in dogs. Radiology 91:719PubMedGoogle Scholar
  49. 48.
    Higgins CB (1977) Effects of contrast media on the conducting system of the heart. Mechanism of action and identification of toxic component. Radiology 124:599PubMedGoogle Scholar
  50. 49.
    Benchimol A, McNally EM (1966) Hemodynamic and electrocardiographic effects of selective coronary arteriography in man. N Engl J Med 274:1217PubMedCrossRefGoogle Scholar
  51. 50.
    Banks DC, Rafferty EB, Oram S (1970) Evaluation of contrast media used in man for coronary arteriography. Br Heart J 32:317PubMedCrossRefGoogle Scholar
  52. 51.
    Brown TG Jr (1967) Cardiovascular actions of angiographic media. Angiology 18:273PubMedCrossRefGoogle Scholar
  53. 52.
    Coskey RL, Magidson O (1967) Electrocardiographic response to selective coronary arteriography. Br Heart J 29:512PubMedCrossRefGoogle Scholar
  54. 53.
    Frink RJ, Merrick B, Lower HM (1975) Mechanism of bradycardia during coronary angiography. Am J Cardiol 35:17PubMedCrossRefGoogle Scholar
  55. 54.
    MacAlpin RN, Weidner WA, Kattus AA, Hanafee WN (1966) Electrocardiographic changes during selective coronary cineangiography. Circulation 34:627PubMedGoogle Scholar
  56. 55.
    Nakhjavan FK, Smith AM, Dratch MB, Goldberg H (1974) His bundle electrogram during coronary arteriography in man: studies at spontaneous and constant heart rates. J Electrocardiol 7:101PubMedCrossRefGoogle Scholar
  57. 56.
    Eckberg DL, White CM, Kioschos JM, Abboud FM (1974) Mechanisms mediating bradycardia during coronary arteriography. J Clin Invest 54:1455PubMedCrossRefGoogle Scholar
  58. 57.
    Perez-Gomez F, Garcia-Aguado A (1977) Origin of ventricular reflexes caused by coronary arteriography. Br Heart J 39:967PubMedCrossRefGoogle Scholar
  59. 58.
    Abe S, Itoh M, Unakami H, Kobazashi T (1976) Sinus slowing produced by intracoronary arterial injections of hyperosmotic solutions in man. Am Heart J 91:339PubMedCrossRefGoogle Scholar
  60. 59.
    Carson RP, Lazzara R (1970) Hemodynamic responses initiated by coronary stretch receptors with special reference to coronary arteriography. Am J Cardiol 25:571PubMedCrossRefGoogle Scholar
  61. 60.
    James TN, Nadeu RA (1963) Sinus bradycardia during injections directly into the sinus node artery. Am J Physiol 204:9PubMedGoogle Scholar
  62. 61.
    Higgins CB, Feld GK (1976) Direct chronotropic and dromotropic actions of contrast media: ineffectiveness of atropine in the prevention of bradyarrhythmias and conduction disturbances. Radiology 121:205PubMedGoogle Scholar
  63. 62.
    Zelis R, Caudill C, Baggette K, Mason DT (1976) Reflex vasodilation induced by coronary angiography in human subjects. Circulation 53:490PubMedGoogle Scholar
  64. 63.
    Daves GE, Comroe JH Jr (1954) Chemoreflexes from the heart and lungs. Physiol Rev 34:167Google Scholar
  65. 64.
    Tragardh B, Bove AA, Lynch PR (1974) Cardiac conduction abnormalities during coronary arteriography in dogs: reduced effects of a new contrast medium. Invest Radiol 9:340PubMedCrossRefGoogle Scholar
  66. 65.
    Tragardh B, Bove AA, Lynch PR (1977) Mechanism of production of cardiac conduction abnormalities due to coronary arteriography in dogs. Invest Radiol 11:563Google Scholar
  67. 66.
    Nakhjavan FK (1973) Recording of His bundle and left bundle potentials during left coronary arteriography in the dog. J Electrocardiol 6:45PubMedCrossRefGoogle Scholar
  68. 67.
    Langou RA, Sheps DS, Wolfson S, Cohen LS (1977) Intraventricular conduction during coronary arteriography in patients with pre-existing conduction abnormalities. Invest Radiol 12:505PubMedCrossRefGoogle Scholar
  69. 68.
    Sostman HD, Simon AL, Langou RA (1977) Localization of the conduction delay occurring during coronary arteriography. Invest Radiol 12:128PubMedCrossRefGoogle Scholar
  70. 69.
    Miller D, Lohse J, Wolf G (1976) Slow response induced in canine Purkinje fiber by contrast medium. Invest Radiol 11:577PubMedCrossRefGoogle Scholar
  71. 70.
    Simon AL, Shabetai R, Lang JH, Lasser EC (1972) The mechanism of production of ventricular fibrillation in coronary angiography. AJR 114:810Google Scholar
  72. 71.
    Paulin S, Adams DF (1971) Increased ventricular fibrillation during coronary arteriography with a new contrast medium preparation. Radiology 101:45PubMedGoogle Scholar
  73. 71a.
    Wolf GL, Kraft L, Kilzer K (1978) Contrast agents lower ventricular fibrillation threshold. Radiology 129:215PubMedGoogle Scholar
  74. 72.
    Hildner JF, Scherlag B, Samet P (1971) Evaluation of Renografin M76 as a contrast agent for angiocardiography. Radiology 100:329PubMedGoogle Scholar
  75. 72a.
    Wolf GL (1980) The fibrillatory propensities of contrast agents. Invest Radiol 15:5208Google Scholar
  76. 73.
    Snyder CF, Formanek A, Frech RS, Amplatz K (1971) The role of sodium in promoting ventricular arrhythmia during selective coronary arteriography. AJR 113:567Google Scholar
  77. 73a.
    Violante MR, Thomson KR, Fischer HW, Kenyon T (1978) Ventricular fibrillation from diatrizoate with and without chelating agents. Radiology 128:497PubMedGoogle Scholar
  78. 74.
    Almen T (1973) Effects of metrizamide and other contrast media on the isolated rabbit heart. Acta Radiol [Suppl] (Stockh) 335:216Google Scholar
  79. 74a.
    Thomson KR, Violante MR, Kenyon T, Fischer HW (1978) Reduction in ventricular fibrillation using calcium enriched Renografin 76. Invest Radiol 13:238PubMedCrossRefGoogle Scholar
  80. 75.
    Gensini GG, DiGiorgi S (1964) Myocardial toxocity of contrast agents used in angiography. Radiology 82:24PubMedGoogle Scholar
  81. 75a.
    Tragardh B, Lynch PR (1978) ECG changes and arrhythmias induced by ionic and nonionic contrast media during coronary arteriography in dogs. Invest Radiol 13:233PubMedCrossRefGoogle Scholar
  82. 76.
    Kilzer K, Mulry BS, LeVeen R (1980) New angiographic agents that are less fibrillatory. Invest Radiol 15:416Google Scholar
  83. 77.
    Moore EN, Spear JF (1975) Ventricular fibrillation threshold. Its physiological and pharmacological importance. Arch Intern Med 135:446PubMedCrossRefGoogle Scholar
  84. 78.
    Ross RS, Gorlin R (1968) Coronary arteriography. Circulation [Suppl 3] 37:67Google Scholar
  85. 79.
    Frech RS (1975) Toxicity studies of coronary arteriographic media in dogs. Invest Radiol 10:323PubMedCrossRefGoogle Scholar
  86. 80.
    Carter AM, Olin T (1976) Ionic composition and cardiotoxicity of dimeric contrast media at injections into the coronary arteries of rabbits. Acta Radiol [Diagn] (Stockh) 17:433Google Scholar
  87. 81.
    Bjork L, Eldh P, Paulin S (1977) Nonionic and dimeric contrast media in coronary angiography. Experimental investigation in dogs. Acta Radiol [Diagn] (Stockh) 18:235Google Scholar
  88. 82.
    Refsum H, Passwal M (1978) Arrhythmogenic and cardiodepressive effects of contrast media on isolated rat atria. Invest Radiol 13:444PubMedCrossRefGoogle Scholar
  89. 83.
    Refsum H, Hotvedt R (1979) Cardiotoxic effects of contrast media on isolated rat atria (Abstr). Circulation [Suppl 2] 59/60:162Google Scholar
  90. 84.
    Brown TG, Hoppe JO, Borisenok WA (1967) Cardiovascular studies of Isopaque B and other radiopaque media. Acta Radiol [Diagn] [Suppl] (Stockh) 270:58Google Scholar
  91. 85.
    Smith RF, Harthorne JW, Sanders CA (1967) Vectorcardiographic changes during intracoronary injections. Circulation 36:63PubMedGoogle Scholar
  92. 86.
    Fernandez F, Scebat L, Lenegre J (1970) Electrocardiographic study of left intraventricular hemiblock in man during selective coronary arteriography. Am J Cardiol 25:1CrossRefGoogle Scholar
  93. 87.
    Eie H, Grendahl H, Nordvik A, Muller C (1972) Electrocardiographic changes during selective coronary angiography. Acta Radiol [Diagn] (Stockh) 12:554Google Scholar
  94. 88.
    Grendahl H, Eie H, Nordvik A, Muller C (1972) Electrocardiographic changes during selective coronary arteriography. Acta Med Scand 191:493PubMedGoogle Scholar
  95. 89.
    Ovitt T, Rizk G, Frech RS, Cramer R, Amplatz K (1972) Electrocardiographic changes in selective coronary arteriography: the importance of ions. Radiology 104:705PubMedGoogle Scholar
  96. 90.
    Tragardh B, Lynch PR, Vinciguerra T (1975) Effects of metrizamide, a new nonionic contrast medium, on cardiac function during coronary arteriography in the dog. Radiology 115:59PubMedGoogle Scholar
  97. 91.
    Tragardh B, Almen T, Lynch B (1975) Addition of calcium or other cations and oxygen to ionic and nonionic contrast media. Effects on cardiac functions during coronary arteriography. Invest Radiol 10:231PubMedCrossRefGoogle Scholar
  98. 92.
    Tragardh B, Lynch PR, Vinciguerra T (1976) Cardiac function during coronary arteriography with calcium-enriched diatrizoate and metrizamide. Invest Radiol 11:569PubMedCrossRefGoogle Scholar
  99. 93.
    Bristow JD, Porter G A, Kloster FE, Griswold HE (1967) Hemodynamic changes attending angiocardiography. Radiology 88:939PubMedGoogle Scholar
  100. 94.
    Wildenthal K, Mierzwiak DS, Mitchell JH (1969) Acute effects of increased serum osmolality on left ventricular performance. Am J Physiol 216:898PubMedGoogle Scholar
  101. 95.
    Karliner JS, LeWinter MM, Mahler F, Engler R, O’Rourke RA (1977) Pharmacologic and hemodynamic influences on the rate of isovolumic and left ventricular relaxation in the normal conscious dog. J Clin Invest 60:511PubMedCrossRefGoogle Scholar
  102. 96.
    Brundage BH, Cheitlin MD (1974) Ventricular function curves from the cardiac response to angiographic contrast: a sensitive detector of ventricular dysfunction in coronary artery disease. Am Heart J 88:281PubMedCrossRefGoogle Scholar
  103. 97.
    Brundage BH, Farr JE (1977) Comparison of contrast medium and atrial pacing as tests of ventricular function in coronary artery disease. Br Heart J 40:250CrossRefGoogle Scholar
  104. 98.
    Kober G, Schroder W, Kaltenbach M (1978) Der Einfluß intrakardialer Kontrastmittelinjektionen auf die Hämodynamik des linken Ventrikels. Z Kardiol 67:474PubMedGoogle Scholar
  105. 99.
    Gensini GG, Dubiel J, Huntington PP, Kelley AE (1971) Left ventricular end-diastolic pressure before and after coronary arteriography. The value of coronary arteriography as a stress test. Am J Cardiol 27:453PubMedCrossRefGoogle Scholar
  106. 100.
    Salvesen S, Nilsen PL, Holtermann H (1967) Ameliorating effects of calcium and magnesium ions on toxicity of isopaque sodium. Acta Radiol [Suppl] (Stockh) 270:30Google Scholar
  107. 101.
    Wildenthal K, Skelton GL, Coleman HN III (1969) Cardiac muscle mechanics in hyperosmotic solution. Am J Physiol 217:307Google Scholar
  108. 102.
    Newell JD, Higgins CB, Kelley MJ, Treen CE, Schmidt WS, Haigier F (1980) The influence of hyperosmolality on left ventricular contractile state. Disparate effects of nonionic and ionic solutions. Invest Radiol 15:363PubMedCrossRefGoogle Scholar
  109. 103.
    Sink JD, Wechsler AS, Pellom GL, Thompson WM (1979) Effects of B-15,000 (iopamidol), a new nonionic contrast agent, on cardiac function of the isolated rat heart. Invest Radiol 14:508PubMedCrossRefGoogle Scholar
  110. 104.
    Higgins CB (1980) Effects of contrast materials on left ventricular function. Invest Radiol 15:5220Google Scholar
  111. 105.
    Kaftori JK, Paulin S (1974) The effect of pH on the toxicity of diatrizoate in selective coronary arteriography. An experimental study in dogs. Invest Radiol 9:351PubMedCrossRefGoogle Scholar
  112. 106.
    Guzman SV, West JW (1959) Cardiac effects of intracoronary arterial injections of various roentgenographic contrast media. Am Heart J 58:597PubMedCrossRefGoogle Scholar
  113. 107.
    Jacobsson B, Paulin S (1967) Experiences with different contrast media in coronary angiography. Acta Radiol [Suppl] (Stockh) 270:103Google Scholar
  114. 108.
    Jacobsson B, Paulin S (1967) Experiences with different contrast media in coronary arteriography. Acta Radiol [Suppl] (Stockh) 270:194Google Scholar
  115. 109.
    Oppenheimer MJ, Ascanio G, Henny CG, Caldwell E, Vineiguerra T (1973) Metabolic and cardiovascular effects of selective intracoronary injections of contrast media. Invest Radiol 8:13PubMedCrossRefGoogle Scholar
  116. 110.
    Kaude JV, Lunderquist A, Persson S, Amman K (1974) Selective coronary angiography with iodamide. A comparison of myocardial toxicity of two contrast media. Angiology 25:449PubMedCrossRefGoogle Scholar
  117. 111.
    Higgins CB, Sovak M, Schmidt W, Kelley MJ, Newell JD (1980) Direct myocardial effects of intracoronary administration of new contrast materials with low osmolality. Invest Radiol 15:39PubMedCrossRefGoogle Scholar
  118. 112.
    Caulfield JB, Zir L, Harthorne JW (1975) Blood calcium levels in the presence of arteriographic contrast material. Circulation 52:119PubMedGoogle Scholar
  119. 113.
    Langer GA (1973) Heart: excitation-contraction coupling. Annu Rev Physiol 35:55PubMedCrossRefGoogle Scholar
  120. 114.
    Moore EW (1969) Studies with ion exchange calcium electrodes in biological fluids: some applications in biological research and clinical medicine. In: Durst RA (ed) Ion specific electrodes. Nat Bur Stand U.S. Spec Publ 314:215Google Scholar
  121. 115.
    Latrou J, Bergin M, Cardinal A (1978) Action of contrast media solutions on cardiac hemodynamic parameters during coronary angiography in the pig. Ann Radiol (Paris) 21:261Google Scholar
  122. 116.
    Thomson KR, Eviel CA, Fritzche J, Beness GT (1980) Comparison of iopamidol, ioxaglate, and diatrizoate during coronary arteriography in dogs. Invest Radiol 15:234PubMedCrossRefGoogle Scholar
  123. 116a.
    Tragardh B, Lynch PR (1980) Cardiac function during left coronary ateriography in canines with ioxaglate, nonionic compounds, and diatrizoate. Invest Radiol 15:449PubMedCrossRefGoogle Scholar
  124. 117.
    Green CE, Higgins CB, Kelley MJ, Newell JD, Schmidt WS (1981) Effects of intracoronary administration of contrast materials on left ventricular function in the presence of severe coronary artery stenosis. Cardiovasc Radiol 4:110–116CrossRefGoogle Scholar
  125. 118.
    Yamazaki H, Banka VS, Bondenheimer MM, Heifant RH (1979) Differential effects of Renografin 76 on ischemic and non-ischemic myocardium (Abstr) Circulation [Suppl 2] 59:244Google Scholar
  126. 119.
    Zipfel J, Baller D, Karsch KR, Reutrop P, Heilige G (1980) Decrease in cardiotoxicity of contrast media in coronary angiography in addition of calcium ions. Combined experimental and clinical study. Clin Cardiol 3:178PubMedGoogle Scholar
  127. 120.
    Wolpers HG, Bailer D, Ensink FBM, et al. (1981) Influence of contrast media on calcium in blood. Cardiovasc Radiol 4:8CrossRefGoogle Scholar
  128. 121.
    Adams DF, Abrams HL (1979) Complications of coronary arteriography: a follow-up report. Cardiovasc Radiol 2:89PubMedCrossRefGoogle Scholar
  129. 122.
    Bourassa MG, Noble J (1976) Complication rate of coronary arteriography. A review of 5,250 cases studied by percutaneous femoral technique. Circulation 53:106PubMedGoogle Scholar
  130. 123.
    Swan HJ (1968) Cooperative study on cardiac catheterization. Complications associated with angiocardiography. Circulation [Suppl 3] 37:81Google Scholar
  131. 124.
    Nitter-Hauge S, Enge I (1976) Metrizoic acid (isopaque coronar) used in man for coronary angiography. Radiology 121:537PubMedGoogle Scholar
  132. 125.
    Mcintosh HD (1968) Cooperative study on cardiac catheterization. Arrhythmias. Circulation [Suppl 3] 37:27Google Scholar
  133. 126.
    Enge I, Nitter-Hauge S, Andrew E, Levorstad K (1977) Amipaque. a new contrast medium in coronary angiography. Radiology 125:317PubMedGoogle Scholar
  134. 127.
    Enge I, Nitter-Hauge S, Levorstad K, et al. (1979) Amipaque in coronary angiography. Diagn Imaging 48:219PubMedGoogle Scholar
  135. 128.
    Ludwig JW (1979) Use of metrizamide in coronary arteriography. Diagn Imaging 48:223PubMedGoogle Scholar
  136. 129.
    Lindgren P (1959) Carotid angiography with tri-iodobenzoic acid derivatives: a comparative experimental study of the effects on the systemic circulation in cats. Acta Radiol (Stockh) 51:353PubMedCrossRefGoogle Scholar
  137. 130.
    Hilal SK (1966) Hemodynamic responses in the cerebral vessels to angiographic contrast media. Acta Radiol (Stockh) 5:211Google Scholar
  138. 131.
    Hilal SK (1966) Hemodynamic changes associated with intra-arterial injection of contrast media. Radiology 86:615PubMedGoogle Scholar
  139. 132.
    Fischer HW, Eckstein JW (1961) Comparison of cerebral angiographic contrast media by their circulatory effects. AJR 86:166Google Scholar
  140. 133.
    Cornell SH, Fischer HW (1967) Comparison of mixtures of metrizoate and iothalamate salts with their methylglucamine solutions by the carotid injection technique. Invest Radiol 2:41PubMedCrossRefGoogle Scholar
  141. 134.
    Fischer HW, Kurland C, Burgener FA (1977) Cardiovascular responses to metrizamide and meglumide sodium diatrizoate in cerebral angiography (Abstr). Invest Radiol 12:440CrossRefGoogle Scholar
  142. 135.
    Lindgren P (1970) Hemodynamic responses to contrast media. Invest Radiol 5:424PubMedCrossRefGoogle Scholar
  143. 136.
    Lindgren P, Tornell G (1958) Blood circulation during and after peripheral arteriography: experimental study of the effects of Triurol (sodium acetrizoate) and hypaque (sodium diatrizoate). Acta Radiol (Stockh) 49:425CrossRefGoogle Scholar
  144. 137.
    Gonzales LL, Stieritz D (1966) Cardiovascular responses to injection of contrast medium into proximal aorta. Radiology 86:1070Google Scholar
  145. 138.
    Marshall RJ, Shepherd JT (1959) Effect of injections of hypertonic solutions on blood flow through the femoral artery of the dog. Am J Physiol 197:951PubMedGoogle Scholar
  146. 139.
    Mellander S, Johansson B, Gray S (1967) The effect of hyperosmolarity on intact and isolated vascular smooth muscle: possible role of exercise hyperemia. Angiologica 4:310PubMedGoogle Scholar
  147. 140.
    Haddy FJ (1960) Local effects of sodium, calcium, and magnesium upon small and large blood vessels of the dog forelimb. Circ Res 8:57PubMedGoogle Scholar
  148. 141.
    Delius W, Erikson V (1969) Effect of contrast medium in blood flow and blood pressure in lower extremities. AJR 107:869Google Scholar
  149. 142.
    Mottram RF, Lynch PR (1970) Circulatory effects of repeated intraarterial injections of Conray 60. Invest Radiol 5:534PubMedCrossRefGoogle Scholar
  150. 143.
    Coel MC, Lasser EC (1971) A pharmacologic basis for peripheral vascular resistance changes with contrast media injections. AJR 111:802Google Scholar
  151. 144.
    Almen T, Tragardh B (1973) Effects of nonionic contrast media on the blood flow through the femoral artery of the dog. Acta Radiol [Suppl] (Stockh) 335:197Google Scholar
  152. 144a.
    Speck U, Siefert H-M, Klesik G (1980) Contrast media and pain in peripheral arteriography. Invest Radiol 15:S335PubMedCrossRefGoogle Scholar
  153. 145.
    Aperia A, Broberger O, Ekengren K (1968) Renal hemodynamics during selective renal angiography. Invest Radiol 3:389PubMedCrossRefGoogle Scholar
  154. 146.
    Talner LB, Davidson AJ (1968) Renal hemodynamic effects of contrast media. Invest Radiol 3:310PubMedCrossRefGoogle Scholar
  155. 147.
    Sherwood T, Lavender JP (1969) Does renal blood flow rise or fall in response to diatrizoate? Invest Radiol 4:327PubMedCrossRefGoogle Scholar
  156. 148.
    Chou CC, Hook JB, Hsieh CP, et al. (1971) Effects of radiopaque dyes on renal vascular resistance. J Lab Clin Med 78:705PubMedGoogle Scholar
  157. 149.
    Caldicott WJH, Hollenberg NK, Abrams HL (1970) Characteristics of response of renal vascular bed to contrast media. Evidence for vasoconstriction induced by reninangiotension system. Invest Radiol 5:539PubMedCrossRefGoogle Scholar
  158. 150.
    Katzberg RW, Morris TW, Burgener FA, Kamm DE, Fischer HW (1977) Renal renin and hemodynamic response to selective renal artery catheterization and angiography. Invest Radiol 12:381PubMedCrossRefGoogle Scholar
  159. 151.
    Katzberg RW, Meggs LG, Hollenberg NK, Abrams HL (1980) Investigations into the decrease in renal blood flow following selective angiography (Abstr). Invest Radiol 15:429CrossRefGoogle Scholar
  160. 152.
    Norby LH, Bibona GF (1975) The renal vascular effects of meglumine diatrizoate. J Pharmacol Exp Ther 193:932PubMedGoogle Scholar
  161. 153.
    Gazitua S, Scott JB, Chou CC, Haddy FJ (1969) Effects of osmolarity on canine renal vascular resistance. Am J Physiol 217:1216PubMedGoogle Scholar
  162. 154.
    Gazitua S, Scott JB, Swindall B, Haddy FJ (1971) Resistance responses to local changes in plasma osmolality in three vascular beds. Am J Physiol 220:384PubMedGoogle Scholar
  163. 155.
    Rüssel SB, Sherwood T (1974) Monomer/dimer contrast media in the renal circulation: experimental angiography. Br J Radiol 47:268CrossRefGoogle Scholar
  164. 156.
    Dorph S, Sovak M, Talner LB, Rosen L (1977) Why does kidney size change during urography? Invest Radiol 12:246PubMedCrossRefGoogle Scholar
  165. 157.
    Morris TW, Katzberg RW, Fischer HW (1978) A comparison of the hemodynamic responses to metrizamide and meglumine/sodium diatrizoate in canine renal arteriography. Invest Radiol 13:74PubMedCrossRefGoogle Scholar
  166. 158.
    Gruskin AB, Auerbach VH, Black IFS (1974) Intrarenal blood flow in children with normal kidneys and congenital heart disease: changes attributable to angiography. Pediatr Res 8:561PubMedGoogle Scholar
  167. 159.
    Read RC, Meyer M (1959) The role of red cell agglutination in arteriography complications. Surg Forum 10:472Google Scholar
  168. 160.
    Johnson JH, Knisely MH (1962) Intravascular agglutination of the flowing blood following the injection of radiopaque contrast media. Neurology (Minneap) 12:560Google Scholar
  169. 161.
    Sutherland GR, Rasensen O (1967) The effects of intra-arterial injections of radiographic contrast media on the mesenteric circulation of rats. Clin Radiol 18:200PubMedCrossRefGoogle Scholar
  170. 162.
    Siegelman SS, Warren A, Veith FJ, Boley SJ (1970) The physiology response to superior mesenteric angiography. Radiology 96:101PubMedGoogle Scholar
  171. 163.
    Sovak M, Rosch J, Lakin RC (1975) Vasodilators in the canine mesenteric circulation. Invest Radiol 10:595PubMedCrossRefGoogle Scholar
  172. 164.
    Itzchak Y, Groszmann RJ, Glickman MG (1978) The effect of hepatic arterial injection of contrast medium, blood, and saline on hepatic artery flow. Invest Radiol 13:528PubMedCrossRefGoogle Scholar
  173. 165.
    Kagstrom E, Lindgren P, Torneil G (1958) Changes in cerebral circulation during carotid angiography with sodium acetrizoate (Trirol) and sodium diatrizoate (Hypaque). An experimental study. Acta Radiol (Stockh) 50:151PubMedCrossRefGoogle Scholar
  174. 166.
    Tindall GT, Greenfield JC Jr, Dillingham W, Lee JF (1965) Effect of 50 percent sodium diatrizoate (Hypaque) on blood flow in the internal carotid artery in man. Am Heart J 69:215PubMedCrossRefGoogle Scholar
  175. 167.
    Herrschaft H, Gleim F, Schmidt H (1974) Effects of angiographic contrast media on regional cerebral blood flow and haemodynamics in man. Neuroradiology 7:95PubMedCrossRefGoogle Scholar
  176. 168.
    Talbert JL, Joyce EE, Sabiston DC Jr (1959) The effect of intra-arterial injection of radiopaque contrast media on coronary blood flow. Surgery 46:400PubMedGoogle Scholar
  177. 169.
    Carson R, Wever WJ, Wilson WS (1969) Effect of selective coronary arteriography on myocardial blood flow in the intact dog. Am J Med Sci 257:228PubMedCrossRefGoogle Scholar
  178. 170.
    Kloster FE, Friesen WG, Green GS, Judkins MP (1972) Effects of coronary arteriography on myocardial blood flow. Circ Res 46:438Google Scholar
  179. 171.
    Tragardh B, Lynch P, Tragardh M (1976) Coronary angiography with diatrizoate and metrizamide. Comparison of ionic and nonionic contrast media effect on coronary blood flow in dogs. Acta Radiol (Stockh) 17:69Google Scholar
  180. 172.
    Lehan PH, Harman MA, Oldewurtel HA (1963) Myocardial water shifts induced by coronary arteriography (Abstr). J Clin Invest 42:950Google Scholar
  181. 173.
    Griggs DM Jr, Nakamura Y, Leunissen RLA, Kasparian H, Novack P (1966) Effects of radiopaque material on phasic coronary flow and myocardial oxygen consumption. Clin Res 14:247Google Scholar
  182. 174.
    Gould KL, Lipscomb K, Hamilton GW (1974) Physiological basis for assessing critical coronary stenosis. Am J Cardiol 33:87PubMedCrossRefGoogle Scholar
  183. 175.
    Gould KL, Lipscomb K (1974) Effects of coronary stenoses on coronary flow reserve and resistance. Am J Cardiol 34:48PubMedCrossRefGoogle Scholar
  184. 176.
    Bassan M, Ganz W, Marcus HS, Swan HJC (1975) the effect of intracoronary injection of contrast medium upon coronary blood flow. Circulation 51:442PubMedGoogle Scholar
  185. 177.
    Yamazaki H, Aya S, Horikawa M, Matsumura N, Nakamura Y (1975) Effects of radiopaque material on coronary vascular reserve. Jpn Heart J 16:57PubMedCrossRefGoogle Scholar
  186. 178.
    Scheibel RL, Moore R, Korbuly D, Ovitt TW, Payne JT, Trexa N, Amplatz K (1975) Regional myocardial blood flow measurement in the evaluation of patients with coronary artery disease. Radiology 115:379PubMedGoogle Scholar
  187. 179.
    Bookstein JJ, Higgins CB (1977) Comparative efficacy of coronary vasodilatory methods. Invest Radiol 12:121PubMedCrossRefGoogle Scholar
  188. 180.
    Lohr VE, Makoski HB, Fiebach O (1972) Contrast tolerance during angiography, with special reference to blood electrolyte changes. ROFO 116:367CrossRefGoogle Scholar
  189. 181.
    Lohr E, Reidemeister JC, Popitz G, Otto H, Timmermann J (1977) Myocardial response to contrast media: effects on electrolyte metabolism and subcellular structures. Invest Radiol 12:135PubMedCrossRefGoogle Scholar
  190. 182.
    Lohr E, Timmermann J, Reidemeister JC, Popitz G (1978) Metabolic action and cellular structure of the myocardium during coronary angiography. Cardiovasc Radiol 1:15CrossRefGoogle Scholar
  191. 183.
    Read RC, Vick J, Meyer MW (1959) Influence of perfusate characteristics on the pulmonary vascular effects of hypertonic solutions (Abstr). Fed Proc 18:124Google Scholar
  192. 184.
    O’Connor JF, Sitzman SB, Dealy JB (1967) Vascular injury due to topical application of cardiovascular contrast medium in the hamster cheek pouch. Radiology 89:20PubMedGoogle Scholar
  193. 185.
    Derrick JR, Brown RW, Livanec G, Bond JP, Guest MM (1968) Experimental effects of selective arteriography on the microcirculation. Am J Surg 116:712PubMedCrossRefGoogle Scholar
  194. 186.
    Almen T, Wiedeman MP (1968) Application of contrast media to the external surface of the vasculature. Effects on microcirculation in the bat wing. Invest Radiol 3:151PubMedCrossRefGoogle Scholar
  195. 187.
    Almen T, Wiedeman MP (1968) Application of monomers and polymers to the external surface of the vasculature. Effects on microcirculation of the bat wing. Invest Radiol 3:408PubMedCrossRefGoogle Scholar
  196. 188.
    Almen T, Standertskjold-Nordenstam N (1969) Effects of dyes on microvasculature of the bat wing in vivo. Invest Radiol 4:63PubMedCrossRefGoogle Scholar
  197. 189.
    Branemark PI, Jacobsson B, Sorensen SE (1969) Microvascular effects of topically applied contrast media. Acta Radiol [Diagn] (Stockh) 8:547Google Scholar
  198. 190.
    Brown RT, Youmans CR Jr, Livanec G, Derrick JR, Bond TP, Guest MM (1968) Cinemicrographic observations of the effects of contrast media on the microcirculation. Vase Surg 2:109Google Scholar
  199. 191.
    Almen T (1973) Application of non-ionic and ionic contrast media to the external vessel surface. Acta Radiol [Suppl] (Stockh) 335:239Google Scholar
  200. 192.
    Tuma RF, Ritchie WGM, Wiedeman MP (1974) Effects of intra-arterially injected contrast media on microvessels in the rat’s cecal mesentery. Invest Radiol 9:273PubMedCrossRefGoogle Scholar
  201. 193.
    Ritchie WGM (1975) The effect of contrast media on normal and inflamed canine venous endothelium (Abstr). Br J Radiol 48:945PubMedCrossRefGoogle Scholar
  202. 194.
    Almen T (1976) Effects on venous vasomotion from the ionic content of contrast agent solutions. Acta Radiol [Diagn] (Stockh) 17:439Google Scholar
  203. 195.
    Ekeland A, Uflacker R (1978) Effect of meglumine metrizoate and metrizamide on the microcirculation. Acta Radiol [Diagn] (Stockh) 19:969Google Scholar
  204. 196.
    Endrich B, Ring J, Intaglietta M (1979) Effects of radiopaque contrast media on the microcirculation of the rabbit omentum. Radiology 132:331PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1984

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  • C. B. Higgins

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