Abstract
Radiologists are particularly aware of the importance of genetic damage since it has been known for many years that X-rays can cause sublethal genetic damage in both clinical and experimental settings [1]. Such damage can be expressed clinically as cancer [1], or as a somatic abnormality in the human fetus [2]. Yet, the current picture of mutagenicity is not in particularly sharp focus. Instances of clear-cut carcinogenic mutagens and teratogenic mutagens have been identified in human populations, usually following a tragic underestimation of the potential danger of a chemical or physical agent. Diagnostic radiology has, in the past, learned about such instances the hard way: many early radiologists died of radiation-induced neoplasms, and even today we continue to see, albeit rarely, patients who recieved thorium dioxide and subsequently developed neoplasms induced by that contrast material [3].
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Nelson, J.A. (1984). Are Contrast Media Mutagenic?. In: Sovak, M. (eds) Radiocontrast Agents. Handbook of Experimental Pharmacology, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69515-5_13
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DOI: https://doi.org/10.1007/978-3-642-69515-5_13
Publisher Name: Springer, Berlin, Heidelberg
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