Abstract
Organic bases taken up orally and thus subject to intestinal absorption may be divided into two classes: (1) regular constituents of food participating in intermediary metabolism like purine and pyrimidine bases and amino acids; and (2) xenobiotic substances amongst which drugs form an important group. Studies on the absorption mechanisms led to the discovery of specific and active transport systems for purine and pyrimidine bases (Csáky 1961; Schanker and Tocco 1960, 1962; Schanker et al. 1963; Kolassa et al. 1977; Scharrer et al. 1981) and for amino acids (for reviews see Wiseman 1974; Schultz and Frizzell 1975) capable of transferring these substances against an electrochemical gradient from the gut lumen into the interstitial space equilibrating with the bloodstream. These transport mechanisms are not the subject of the present chapter.
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Lauterbach, F. (1984). Intestinal Permeation of Organic Bases and Quaternary Ammonium Compounds. In: Csáky, T.Z. (eds) Pharmacology of Intestinal Permeation II. Handbook of Experimental Pharmacology, vol 70 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69508-7_5
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