Intestinal Permeability to Calcium and Phosphate

  • L. R. Forte
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 70 / 1)


Calcium and phosphorus are critical elements in the maintenance of living systems. Thus, elegant regulatory mechanisms have evolved by which calcium and phosphorus homeostasis is maintained. In vertebrates, the intestine, kidney, and bone are intimately involved in this process and in fish, the gills appear also to regulate mineral homeostasis. A number of endocrine organs function in the orchestration of mineral homeostasis, including the parathyroid gland, parafollicular cells (C-cell) of the thyroid, and the endocrine kidney. In addition, endocrine factors from the adrenals, gonads, thyroid, and pituitary appear, either directly or indirectly, to influence calcium and phosphorus homeostasis. The purpose of this chapter is to focus primarily on the current views of the mechanisms involved in the intestinal transport of calcium and inorganic phosphate in relation to mineral absorption, with particular emphasis on the physiologic and biochemical mechanisms of calcium and phosphate transport.


Estrogen Xylose Cytosol Macromolecule Strontium 


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  • L. R. Forte

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