Abstract
Morphine which is intrathecally administered interferes with the spinal function by inhibiting the liberation of P substances in the substantia. gelatinosa. The transmission of nociception is blocked at the spinal level [1–3, 7,14,11–13,17, 20, 21, 22]. On the basis of this evidence, it was possible to give spinal anesthesia with morphine for operations followed by very painful postoperative [5], used in this manner, morphine gives produces exceptional pain relief[7,17,18]. During animal and human trials of intrathecal application of morphine, endesired side effects were not noticed in animals and no narcotics dependence was senn in cancer patients [15,16,18,20,23].
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Devaux, C.B., Tessier, C. (1984). Clinical Survey of Spinal Anesthesia with Morphine. In: Wüst, H.J., Zindler, M., d’Arcy Stanton-Hicks, M. (eds) Neue Aspekte in der Regionalanaesthesie 3. Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69453-0_25
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DOI: https://doi.org/10.1007/978-3-642-69453-0_25
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