Clinical Evaluation of Cimetidine with Special Reference to Socioeconomic Effects
From the advent of this century to the beginning of the 1960s there was an increase in the prevalence of peptic ulcers. It is a matter of dispute whether there has been a decrease during recent decades and especially during the last few years. The prevalence of peptic ulcer disease in 50-year-old men and women has been found to be between 10% and 15%. The incidence in men between 50 and 60 years of age and without a previous peptic ulcer history has been found to be about 3%. The incidence of peptic ulcers in patients with a previous known ulcer disease is harder to evaluate partly because it is dependent on the length of time the patient had the previous active ulcer and also on the attitude to treatment among physicians and surgeons as medical or surgical treatment can substantially decrease the incidence of recurrences as we shall see. In Sweden about 3%–4% of men between the ages of 32 and 60 years are absent some time every year because of dyspepsia and in about one-third of cases the cause of the dyspepsia has been found to be due to or related to peptic ulcer disease. In patients where an active peptic ulcer has been found the mean absence - at least in the recent past — was rather stable at about 40 days per year. These figures give a rough impression of the prevalence, incidence, and socioeconomic impact of peptic ulcer disease in a Scandinavian community before the introduction of cimetidine.
KeywordsPlacebo Histamine Dine Cimetidine Dyspepsia
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