Abstract
Because the hilus of the lung does not anchor it very securely, the lung is largely supported by the pleural surfaces and ist therefore subjected to the combined forces of subatmospheric (negative) pleural pressures and the effects of gravity on the lung structure itself. As a result of these combined forces, intrapleural pressure is lower [15] and pulmonary alveoli are larger in size at the apex than at the base of the upright lung [20]. The lower regions of the lung are thus relatively compressed, while the upper parts are relatively overexpanded [37].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ahmed T, Oliver W Jr, Wanner A (1983) Variability of hypoxic pulmonary vasoconstriction in sheep. Am Rev Respir Dis 127: 59–62
Albert RK, Lakshminarayan S, Wayne K, Butler J (1980) Lung inflation can cause pulmonary edema in zone I of in situ dog lungs. J Appl Physiol 49 /5: 815–819
Alexander JM, Nyby MD, Jasberg KA (1976) Effekt of angiotensin on hypoxic pulmonary vasoconstriction in isolated dog lung. J Appl Physiol 41 /1: 84–88
Arborelius M Jr, Bo L (1972) Haemodynamic changes at different lung volumes. J Clin Lab Invest 29: 359–369
Badeer HS (1982) Gravitational effects on the distribution of pulmonary blood flow: Hemodynamic misconceptions. Respiration 43: 408–413
Barer GR, Howard P, McCurrie JR (1967) The effect of carbon dioxide and changes in blood pH on pulmonary vascular resistance in cats. Clin Sci 32: 361–376
Benumof JL (1979) Hypoxic pulmonary vasoconstriction and sodium nitroprusside infusion (editorial). Anesthesiology 50: 481–483
Benumof JL (1979) Mechanism of decreased blood flow to atelectatic lung. J Appl Physiol 46: 1047–1048
Benumof JL (1983) Intermittent hypoxia increases lobar hypoxic pulmonary vasoconstriction. Anesthesiology 58: 399–404
Benumof JL, Wahrenbrock EA (1975) Blunted hypoxic pulmonary vasoconstriction by increased lung vascular pressures. J Appl Physiol 38: 846–850
Benumof JL, Wahrenbrock EA (1975) Local effects of anaesthetics on regional hypoxic pulmonary vasoconstriction. Anesthesiology 43: 525–532
Benumof JL, Mathers JM, Wahrenbrock EA (1976) Cyclic hyoxic pulmonary vasoconstriction induced by concomitant carbon dioxide changes. J Appl Physiol 41: 466–469
Benumof JL, Rogers SN, Moyce PR, Berryhill RE, Wahrenbrock EA, Saidman LJ (1979) Hypoxic pulmonary vasoconstriction and regional and whole-lung PEEP in the dog. Anesthesiology 51: 503–507
Bergofsky EH, Lehr DE, Fishman AP (1962) The effect of changes in hydrogen ion concentration on the pulmonary circulation. J Clin Invest 41: 1492–1501
Coulam CM, Wood EH (1971) Regional differences in pleural and esophageal pressures in head-up and head-down positions. J Physiol 31: 277–287
Ekelund LC, Holmgreen A (1967) Central hemodynamics during exercise. Circ Res [Suppl] 20 /21: 133–143
Emery CJ, Sloan PJM, Mohamed FH, Barer GR (1977) The action of hypercapnia during hypoxia on pulmonary vessels. Bull Eur Physiopathol Respir 13: 763–776
Fishman AP (1976) Hypoxia on the pulmonary circulation: How and when it acts. Circ Res 38: 221–231
Fishman AP (1976) State of the art. Chronic cor pulmonale. Am Rev Respir Dis 114: 775–794
Glazier JB, Hughes JMB, Maloney JE, Pain MCF, Webb JB (1966) Decreasing alveolar size from apex to base in the upright lung. Lancet II: 203–204
Hopewell PC (1979) Failure of positive endexpiratory pressure to decrease lung water content in alloxan-induced pulmonary edema. Am Rev Respir Dis 120: 813–819
Hyman AL, Spannhake EW, Kadowitz PJ (1977) Prostaglandins and the lung. Am Rev Respir Dis 117: 111–136
Ingram RH Jr, Sziden JP, Fishman AP (1970) Response of the main pulmonary artery of the dogs to neuronally released versus blood-borne norepinephrine. Circ Res 26: 249
Junod AF (1975) Metabolism, production and release of hormones and mediators in the lung. Am Rev Respir Dis 112: 93–107
Laver MB, Pohost GM, Strauss HW (1980) Hemodynamic adjustments in acute respiratory failure: The role of the right ventricle. In: Peter K (Hrsg) Akute respiratorische Insuffizienz. Springer, Berlin Heidelberg New York (Anaesthesiologie und Intensivmedizin, Bd 131, S 104–121 )
Lee G de J (1971) Regulation of the pulmonary circulation. Br Hearth J [Suppl] 33: 15–26
Lilja B (1972) Pulmonary blood flow distribution at different lung volumes and body positions. Scand J Clin Lab Invest 29: 351–358
Lucas CL, Wilcox Benson R, Coulter NA Jr (1975) Pulmonary vascular response to atrial septal defect closure in children. J Surg Res 18: 571–586
Malik AB (1977) Pulmonary vascular response to increase in intracranial pressure: Role of sympathetic mechanisms. J Appl Physiol 42 /3: 335–343
Malik AB, Kidd BSL (1973) Time course of pulmonary vascular response to hypoxia in dogs. Am J Physiol 224 /1: 1–6
Mentzer RM Jr, Rubio R, Berne RM (1975) Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation. Am J Physiol 229 /6: 1625–1631
Permutt S, Bronberger-Barnea B, Bane HN (1962) Alveolar pressure, pulmonary venous pressure and the vascular waterfall. Med Thorac 19: 239–266
Pirlo AF, Benumof JL, Trousdale FR (1981) Atelectatic lobe blood flow: Open vs. closed chest, positive pressure vs. spontaneous ventilation. J Appl Physiol 50 /5: 1022–1026
Said SI (1982) Metabolic functions of the pulmonary circulation. Circ Res 50: 325–333
Shapiro BJ, Simmons DH, Linde LM (1966) Pulmonary hemodynamics during acute acid-base changes in the intact dog. Am J Physiol 210 /5: 1026–1032
Suter PM, Fairley B, Isenberg MD (1975) Optimum end-expiratory pressure in patients with pulmonary failure. N Engl J Med 292: 284
West JB, Matthews FL (1972) Stresses, strains, and surface pressures in the lung caused by its weight. J Appl Physiol 32: 332–345
West JB, Dollory CT, Noimark A (1964) Distribution of blood flow in isolated lung, relation to vascular and alveolar pressures. J Appl Physiol 19: 713–724
West JB, Dollery CT, Heard BE (1965) Increased pulmonary vascular resistance in the dependent zone of the isolated dog lung caused by perivascular edema. Circ Res 17: 191–206
Wittenberger JL, McGreyor M, Berglund E et al (1960) Influence of state of inflation of the lung on pulmonary vascular resistance. J Appl Physiol 15: 878
Zapol WM, Snider MT (1977) Pulmonary hypertension in severe acute respiratory failure. N Engl J Med 296: 476–480
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Juhl, B. (1986). Pulmonary Pressure Gradients and Hemodynamics. In: Hossli, G., Frey, P., Kreienbühl, G. (eds) ZAK Zürich. Anaesthesiologie und Intensivmedizin/Anaesthesiology and Intensive Care Medicine, vol 187. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69432-5_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-69432-5_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12979-0
Online ISBN: 978-3-642-69432-5
eBook Packages: Springer Book Archive