Abstract
The commonly used antihypertensive drugs like nitroglycerine, sodium nitroprusside, hydralazine and diazoxide are cerebral vasodilators: their use tends to increase cerebral blood flow, cerebral blood volume and intracranial pressure(1–4).In the normal human brain any increase in intracranial pressure due to vasodilator stimuli will be temporary. Compensation for blood volume increase is ensured by alternating the inflow and outflow of cerebrospinal fluid. In patients whose intracranial pressure is already increased or whose intracranial compliance is decreased, the compensatory mechanism may fail, and intracranial pressure may increase dramatically. As long as the skull remains closed an excessive increase in intracranial pressure may lead to brain herniation. Because of the simultaneous decrease in mean arterial pressure, a dangerous decrease of cerebral perfusion pressure may eventually lead to cerebral ischaemia. In this study the influence of labetalol, urapidil and ketanserin on intracranial pressure and compliance has been investigated.
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References
Cottrell J E, Patel K, Ransohoff JR (1978) Intracranial pressure changes induced by sodium nitroprusside in patients with intracranial mass lesions. J Neurosurg 48: 329
Gagnon RL, Shapiro HM (1979) The effect of diazoxide on intracranial pressure in cats with intracranial mass lesions. Anesthesiology 51: 200
Gupta B, Cotrell JE (1980) Nitroprusside and nitroglycerin induced intracranial pressure changes. In: Shulman K, Marmarou A, Miller JD, Becker DP, Hochwald GM, Brock M (eds) Intracranial pressure IV. Berlin Heidelberg New York, Springer, p 613
van Aken H, Puchstein CH, Hidding J (1982) The prevention of hypertension at intubation. Use of Hydralazine. Correspondence. Anaesthesia 37: 82
Richards DA, Prichard BNC (1979) Clinical pharmacology of Labetalol. Brit J Clin Pharmacol 8: 8 9
Schoetensack W, Bischler P, Dittmann ECH, Steinijans V (1977) Tierexperimentelle Untersuchungen über den Einflut des Antihypertensivums Urapidil auf den Kreislauf and die Kreislaufregulation. Arzneim.-Forsch/Drug Res 27 (II), 1908
Janssen PAJ (1981) The Pharmacology of specific, pure and potent Serotonin 5-HT2-Antagonists. VII. International Congress of Pharmacology, Tokyo, Japan, July 19 - 24, 1981
Miller JD (1975) Volume and pressure in the craniospinal axis. In: Wilkins RH (ed) Clinical neurosurgery. Baltimore, The Williams & Wilkins Co, p 76
Langfitt TW (1980) Closing discussion on IV. Intracranial Pressure Symposium: “Where have we been, where are we now, and where do we go from here?”. In: Shulman K, Marmarou A, Miller JD, Becker DP, Hochwald GM, Brock M (eds) Intracranial pressure I V. Berlin Heidelberg New York, Springer
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© 1983 Springer-Verlag Berlin Heidelberg
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Van Aken, H., Lawin, P., Puchstein, C. (1983). The Influence of Antihypertensive Drugs on Intracranial Pressure. In: Vickers, M.D., Lunn, J.N. (eds) Mortality in Anaesthesia. European Academy of Anaesthesiology, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69355-7_64
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DOI: https://doi.org/10.1007/978-3-642-69355-7_64
Publisher Name: Springer, Berlin, Heidelberg
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