Effects of Anaesthesia on Haemodynamic Responses to Haemorrhage

  • M. Zimpfer
  • E. Kotae
  • N. Mayer
  • P. Placheta
  • K. Steinbereithner
Part of the European Academy of Anaesthesiology book series (ANAESTHESIOLOGY, volume 3)


The traditional concepts of haemodynamic responses to harmorrhage have been derived primarily from studies in anaesthetized animals, often by using indirect techniques for measuring blood flow. It is, however, well recognized that general anaesthetic agents exert a variety of influences on the cardiovascular system and its control by the autonomic nervous system(1–6). Moreover, the effects of the anaesthetic agents can be modified further by concomitant surgical trauma(7).


Arterial Pressure Total Peripheral Resistance Haemodynamic Response Total Blood Loss Peripheral Vasoconstriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Vatner SF (1978) Effects of anesthesia on cardiovascular control mechanisms. Environ Health Perspect 26: 193PubMedCrossRefGoogle Scholar
  2. 2.
    Merin RG, Kumazawa T and Luka NL (1976) Enflurane depresses myocardial function, perfusion and metabolism in the dog. Anesthesiology 45: 501PubMedCrossRefGoogle Scholar
  3. 3.
    Horan BF, Prys-Roberts C, Hamilton WK and Roberts JG (1977) Haemodynamic responses to enflurane anesthesia and hypovolaemia in the dog, and their modification by propranolol. Br J Anaesth 49: 1189PubMedCrossRefGoogle Scholar
  4. 4.
    Zimpfer M, Gilly H, Krosl P, Schlag G and Steinbereithner K (in press) Importance of myocardial loading conditions in determining the effects of enflurane on left ventricular function in the intact and isolated canine heart. AnesthesiologyGoogle Scholar
  5. 5.
    Beck A, Zimpfer M, Raberger G (in press) Inhibition of the carotid chemoreflex by enflurane in chronically instrumented dogs. Naunyn-Schmied Arch PharmacolGoogle Scholar
  6. 6.
    Zimpfer M, Manders WT, Barger AC, Vatner SF (in press) Pentobarbital alters compensatory neural and humoral mechanisms in response to haemorrhage. Am J PhysiolGoogle Scholar
  7. 7.
    Fray JCW, Siwek LG, Strull WM, Steller RN and Wilson JM (1976) Influence of dietary sodium on renin activity and arterial pressure during anesthesia. Am J Physiol 231: 1185PubMedGoogle Scholar
  8. 8.
    Armitage P (1971) Statistical methods in medical research. Oxford, Blackwell Sci-entific PublicationsGoogle Scholar
  9. 9.
    Chien S (1967) Role of the sympathetic nervous system in haemorrhage. Physiol Ref 47: 214Google Scholar
  10. 10.
    Haddy FJ, Overbeck HW, Daugherty RM Jr (1968) Peripheral Vascular resistance. Ann Rev Med 19: 167PubMedCrossRefGoogle Scholar
  11. 11.
    Guyton AC (1976) Textbook of medical physiology. Philadelphia London Toronto, WB SaundersGoogle Scholar
  12. 12.
    Morton M, Duke PC and Ong B (1980) Baroreflex control of heart rate in man awake and during enflurane and enflurane-nitrous oxide anesthesia. Anesthesiology 52: 221PubMedCrossRefGoogle Scholar
  13. 13.
    Weiskopf RB, Townsley MI, Riordan KK, Chadwick K, Baysinger M and Mahoney E (1981) Comparison of cardiopulmonary responses to graded haemorrhage during enflurane, halothane, isoflurane, and ketamine anesthesia. Anaesth Analg 60: 481CrossRefGoogle Scholar
  14. 14.
    Schumacher IG and Arndt JO (1978) Der Effekt von Methohexital, Fentanyl, De- hydrobenzperidol sowie von Chloralone auf die Aktivitat des Aortenbogens decere- brierter Katzen. Anaesthetist 27: 10Google Scholar
  15. 15.
    Zimpfer M, Beck A, Mayer N, Raberger G and Steinbereithner K (in press) Einfluft von Morphium auf die Kontrolle des kardiovaskularen Systems durch den Carotis- Sinus-Reflex und den Carotis-Chemoreflex. AnaesthesistGoogle Scholar
  16. 16.
    Marta JA, Davis HS and Eisele JH (1973) Vagomimetic effects of morphine and In- novar in man. Anaesth Analg 52: 817CrossRefGoogle Scholar
  17. 17.
    Hug CC Jr (1982) Anesthetic agents and the patient with cardiovascular disease. In: Ream AK, Fogdall RP (eds) Acute cardiovascular management. Philadelphia Toronto, J.B. Lippincott, p 247Google Scholar
  18. 18.
    Eger II EI (1976) Anesthetic uptake and action. Baltimore, Williams and WilkinsGoogle Scholar
  19. 19.
    Biscoe TJ, Bardley GW and Purves MJ (1970) The relation between carotid body chemoreceptor discharge, carotid sinus pressure, and carotid body venous flow. J Physiol 208: 99PubMedGoogle Scholar
  20. 20.
    Zimpfer M, Beck A, Raberger G, Mayer N and Steinbereithner K (1982) Effects of fentanyl on the carotid chemoreflex. Anesthesiology 57: A296CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • M. Zimpfer
  • E. Kotae
  • N. Mayer
  • P. Placheta
  • K. Steinbereithner

There are no affiliations available

Personalised recommendations