Automated Autoradiographic Analysis of Tumor Cell Colonies in vitro
The studies reported below are basic to the design of therapeutic strategies against cancer and to the understanding of therapeutic effects. It is unlikely that clinical therapy could employ the same methodology, however, so this approach could not be incorporated into “kinetics-directed” therapy. As defined and implemented successfully by Barranco et al. (1982a, b), therapy is kinetics-directed when the kinetic properties of cell populations under treatment are actually determined and used to schedule the timing of multiple treatments. Thus, the substance of this paper is of potential importance to kinetics-based cancer therapy, i.e. using historical or empirical data to formulate models.
KeywordsSarcoma Thymidine Dine Tritium Photography
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- 5.Elkind MM, Whitmore GF (1967) The radiobiology of cultured mammalian cells. Gordon and Breach, New YorkGoogle Scholar
- 6.Hoffman R (1977) The modulation contrast microscope: Principles and performance. J Microsc 110, Part 3:205–222Google Scholar
- 9.Kallman RF, Combs CA, Franko AJ, Furlong BM, Kelley SD, Kemper HL, Miller RF, Rapacchietta D, Schoenfeld D, Takahashi M (1980) Evidence for the recruitment of noncycling clonogenic tumor cells. In: Meyn RE and Withers HR (eds) Radiation Biology in Cancer Research, Raven Press, New York, pp 397–414Google Scholar