Clot Lysis in Peripheral Arteries

Conference paper


There is no longer any doubt that platelet adhesion and coagulation on the vessel wall are processes essential to the beginning and the progression of every kind of obliterative arteriopathies [8–10, 14, 15, 20]. The material for complete occlusion of an artery is always predominantly thrombotic. As long as this thrombotic material is not already organized, it can be lysed and changed back to normally flowing blood by thrombolytic therapy [4, 19]. If obliterative arteriopathy leads to symptoms within a few days after occurrence — and this happens when total occlusion of an artery develops rapidly — this arteriopathy may be completely cured by thrombolytic therapy [13]. Similarly, an embolic occlusion of an artery can be lysed completely within the first weeks after its occurrence. More patients seek treatment because chronic arteriopathy is symptomatic for weeks or months or becomes worse within this time. These progressive obliterative arteriopathies can be fully reversed by systemic thrombolytic therapy or by local low-dose thrombolytic therapy.


Thrombolytic Therapy Peripheral Artery Clot Lysis Segmental Occlusion Thrombotic Material 
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© Springer-Verlag Berlin Heidelberg 1983

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  • H. Hess

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