Abstract
Nafazatrom (BAY G 6575), 3-methyl-l-[2-(2-naphthyloxy)-ethyl]-2-pyra-zolin-5-one, is under development as an antithrombotic drug with a novel mode of action [1]. Its antithrombotic activity was demonstrated in experimentally induced thrombosis, especially in models based on the following freezing technique. The blood vessels of rats, rabbits, and guinea pigs were exposed and dissected free from the surrounding tissue. The jugular vein and the carotid artery of rats or guinea pigs and the femoral arteries of rabbits were used in most of the experiments. The vessels were frozen at −12° C to −15° C over a length of approximately 1 cm in a metal groove for 2–5 min and simultaneously compressed by a weight of 200 g (rat, guinea pig) or 500 g (rabbit). In addition, arteries were clamped with a small silver clip (diameter 0.15–0.20 mm) distally to the lesion. The experimental device is described elsewhere [2].
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References
Seuter F, Busse WD, Meng K, Hoffmeister F, Möller E, Horstmann H (1979) The antithrombotic activity of BAY G 6575. Arzneimittelforsch/Drug Res 29(1): 54–59.
Schmidt R (1975) Eine neue Methode zur Erzeugung von Thromben durch Unterkühlung der Gefäßwand und ihre Anwendung zur Prüfung von Acetylsalicylsäure und Heparin. Inaugural-Dissertation, Gießen.
Meng K (1975) Tierexperimetnelle Untersuchungen zur antithrombotischen Wirkung von Acetylsalicylsäure. Ther Ber 47: 69–79.
Meng K (1976) Tierexperimentelle Thrombose und Behandlung mit Acetylsalicylsäure. Med Welt 27: 1359–1362.
Meng K, Seuter F (1977) Effect of acetylsalicylic acid on experimentally induced arterial thrombosis in rats. Naunyn-Schmiederberg’s Arch Pharmacol 301: 115–119.
Vermylen J, Chamone DAF, Verstraete M (1979) Stimulation of prostacyclin release from vessel wall by BAY G 6575, an antithrombotic compound. Lancet 1: 518–520.
MacIntyre DE, Salzman EW (1981) Effects of BAY G 6575 on platelets and on vascular PGI2 production. Thromb Haemost 46:19.
Carreras LO, Chamone DAF, Klerckx P, Vermylen J (1980) Decreased vascular prostacyclin (PGI2) in diabetic rats. Stimulation of PGI2 release in normal and diabetic rats by the antithrombotic compound BAY G 6575. Thromb Res 19: 663–670.
Eling TE, Honn KV, Busse WD, Seuter F, Marnett LJ (1982) Stimulation of PGI2 biosynthesis by Nafazatrom (BAY G 6575). In: Powles T J et al. (eds.) Prostaglandins and Cancer. New York, Alan Liss Inc., pp. 783-787.
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© 1983 Springer-Verlag Berlin Heidelberg
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Seuter, F. (1983). Nafazatrom: A New Antithrombotic Compound. In: Dotter, C.T., Grüntzig, A.R., Schoop, W., Zeitler, E. (eds) Percutaneous Transluminal Angioplasty. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69278-9_17
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DOI: https://doi.org/10.1007/978-3-642-69278-9_17
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