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4-Aminoquinolines and Mannich Bases

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Antimalarial Drug II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 68 / 2))

Abstract

The antimalarial 4-aminoquinolines and Mannich bases have been compiled and/or discussed in a number of compendia and reviews. These reviews have, for the most part, considered only those drugs or compounds that have shown an activity sufficient to focus broad attention upon them. Because established drugs are discussed elsewhere in this volume (see Chap. 1), much of the discussion in this chapter will centre on research and development efforts to obtain new 4-aminoquinolineor Mannich base-type antimalarials. The various efforts described are based upon reasonable medicinal chemical rationales, but the research was exploratory and the synthesis of compounds competitive with chlorquine or amodiaquine would not necessarily be immediately anticipated.

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Authors
  1. T. R. Sweeney
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  2. R. O. Pick
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Editors and Affiliations

  1. London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, Great Britain

    Wallace Peters M.D., DSc, FRCP, DTM & H (Professor of Medical Protozoology) (Professor of Medical Protozoology)

  2. Wellcome Research Laboratories, Ravens Lane, Berkhamsted, Herts., HP4 2DY, Great Britain

    William H. G. Richards BSc, Ph. D. (Manager, Scientific Advisory Services) (Manager, Scientific Advisory Services)

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© 1984 Springer-Verlag Berlin Heidelberg

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Sweeney, T.R., Pick, R.O. (1984). 4-Aminoquinolines and Mannich Bases. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drug II. Handbook of Experimental Pharmacology, vol 68 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69254-3_12

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  • DOI: https://doi.org/10.1007/978-3-642-69254-3_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69256-7

  • Online ISBN: 978-3-642-69254-3

  • eBook Packages: Springer Book Archive

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