Skip to main content
SpringerLink
Log in

Anti-Inflammatory Agents: Nonsteroidal Anti-Inflammatory Drugs

  • Chapter
Book cover Pharmacology of the Eye

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 69))

Abstract

Nonsteroidal anti-inflammatory compounds (NSAIDS) have been used since 1763, when Edward Stone described the therapeutic properties of an extract of willow bark upon ague. Although almost four centuries have passed since the first medical use of aspirin and more than four decades since its use for ocular conditions (Gifford 1947; for review see Sears 1974; Leopold and Murray 1979), the mechanism of the anti-inflammatory action of NSAIDS has yet to be clarified. The strong influence of these drugs on the phenomena of fever, pain, and inflammation, taken together with the known undesirable side effects of steroids, has made them of prime interest in ophthalmic therapeutics (Leopold and Murray 1979).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abrishami MA, Thomas J (1977) Aspirin intolerance — a review. Ann Allergy 39:28

    PubMed  CAS  Google Scholar 

  • Anderson JA, Chen CC, Vita JB, Shackleton M (1982) Disposition of topical flurbiprofen in normal and aphakic rabbit eyes. Arch Ophthalmol 100:642–645

    Article  PubMed  CAS  Google Scholar 

  • Arai Y, Shimoji K, Konno M, Konishi Y, Okuyama S, Iguchi S, Hayashi M, Miyamoto T, Toda M (1983) Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds. J Med Chem 26:72–78

    Article  PubMed  CAS  Google Scholar 

  • Arnaud B (1971) The prevention of postoperative inflammation in ocular surgery by the use of Tandearil. Arch Ophthalmol (Paris) 31:349

    CAS  Google Scholar 

  • Bhattacherjee P, Eakins KE (1974 a) Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin. Br J Pharmacol 50:227–230

    PubMed  CAS  Google Scholar 

  • Bhattacherjee P, Eakins KE (1974 b) A comparison of the inhibitory activity of compounds on ocular prostaglandin biosynthesis. Invest Ophthalmol 13:967

    PubMed  CAS  Google Scholar 

  • Bhattacherjee P, Hammond BR, Williams RN, Eakins KE (1980) Arachidonic acid lipoxygenase products in ocular tissues and their effect on leukocyte infiltration in vivo. Proc Int Soc Eye 1:32

    Google Scholar 

  • Bhattacherjee P, Hammond BR, Salmon J A, Stepney R, Eakins KE (1981) Chemotactic response to some arachidonic acid lipoxygenase products in the rabbit eye. Eur J Pharmacol 73:21–28

    Article  PubMed  CAS  Google Scholar 

  • Borgeat P, Samuelsson B (1979 a) Metabolism of arachidonic acid in polymorphonuclear leukocytes: structure analysis of novel hydroxylated compounds. J Biol Chem 254:7865–7869

    PubMed  CAS  Google Scholar 

  • Borgeat P, Samuelsson B (1979 b) Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids. Proc Natl Acad Sci USA 76:3213–3217

    Article  PubMed  CAS  Google Scholar 

  • Brune K (1977) The importance of pharmacokinetics for the action of nonsteroid anti-inflammatory drugs. In: Ritshel WA (ed) Clinical pharmacokinetics, proceedings of an international sysmposium at Salzgitter-Rinzelheim (Germany). Fischer, Stuttgart, p 96

    Google Scholar 

  • Burns CA (1968) Indomethacin, reduced retinal sensitivity, and corneal deposit. Am J Ophthalmol 66:825

    PubMed  CAS  Google Scholar 

  • Carr RE, Siegel IM (1973) Retinal function in patients treated with indomethacin. Am J Ophthalmol 75:302

    PubMed  CAS  Google Scholar 

  • Chavis RM, Uygantas CM, Uygantas A (1976) Experimental inhibition of prostaglandin-like inflammation after cryotherapy. Am J Ophthalmol 82:310

    PubMed  CAS  Google Scholar 

  • Cooper CA, Bergamini MVW, Leopold IH (1980) Use of flurbiprofen to inhibit corneal neovascularization. Arch Ophthalmol 98:1102–1105

    Article  PubMed  CAS  Google Scholar 

  • Crawford JS, Lewandowski RL, Chan W (1975) The effect of aspirin on rebleeding in traumatic hyphema. Am J Ophthalmol 80:543–545

    PubMed  CAS  Google Scholar 

  • Crook D, Collins AJ, Rose AJ (1976) A comparison of the effects of flurbiprofen on prostaglandin synthetase from human rheumatoid synovium and enzymatically active animal tissues. J Pharm Pharmacol 28:535

    Article  PubMed  CAS  Google Scholar 

  • Dewar AJ, Gillian B, Readin HW (1975) The effect of retinol and acetylsalicylic acid on the release of lysosomal enzymes from rat retina in vitro. Exp Eye Res 20:63

    Article  PubMed  CAS  Google Scholar 

  • Dyster-Aas K (1973) Oxyphenbutazone eye ointment in the treatment of foreign bodies in the cornea. Acta Ophthalmol 51:791

    CAS  Google Scholar 

  • Eakins KE (1974) Prostaglandins and prostaglandin synthetase inhibitors: actions in ocular disease: In: Robinson HJ, Vane JR (eds) Prostaglandin synthetase inhibitors. Raven, New York, p 343

    Google Scholar 

  • Flower RJ, Blackwell GJ (1979) Anti-inflammatory steroids induce biosynthesis of a phos-pholipase A2 inhibitor which prevents prostaglandin production. Nature 278:456

    Article  PubMed  CAS  Google Scholar 

  • Flower RJ, Vane JR (1972) Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of paracetamol (4-acetamido-phenol). Nature 238:104

    CAS  Google Scholar 

  • Fowler PD, Wildinson P (1973) Treatment of anterior uveitis, comparison of oral oxyphenbutazone and topical steroids. Br J Ophthalmol 57:892

    Article  PubMed  Google Scholar 

  • Gieser DK, Hodapp E, Goldberg I, Kass MA, Becker B (1981) Flurbiprofen and intraocular pressure. Ann Ophthalmol 13:831–833

    PubMed  CAS  Google Scholar 

  • Gifford SR (1947) A handbook of ocular therapeutics. Lea and Febinger, Philadelphia, p 92

    Google Scholar 

  • Goetzl EJ, Sun FF (1979) Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils. J Exp Med 150:406

    Article  PubMed  CAS  Google Scholar 

  • Goetzl EJ, Hill HR, Gorman RR (1980) Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid. Prostaglandins 19:71

    Article  PubMed  CAS  Google Scholar 

  • Ham EA, Cirillo VJ, Zanetti M, Shen TY, Kuehl FA (1972) Studies on the mode of action of non-steroidal anti-inflammatory agents. In: Ramwell PW, Pharriss BB (eds) Prostaglandins in cellular biology. Plenum, New York, p 345

    Google Scholar 

  • Hanna C, Sharp JD (1972) Ocular absorption of indomethacin by rabbit. Arch Ophthalmol 88:196–198

    Article  PubMed  CAS  Google Scholar 

  • Hayasaka S, Masuda K, Sears ML (1981) Nonsteroid anti-inflammatory drugs stabilize the blood-aqueous barrier and lysosomal enzymes in the rabbit eye. Jpn J Ophthalmol 25:210–216

    CAS  Google Scholar 

  • Huang K, Peyman GA, McGetrick J, Janevicius R(1977) Indomethacin inhibition of prostaglandin-mediated inflammation following intraocular surgery. Invest Ophthalmol 16:760–762

    CAS  Google Scholar 

  • Ishii H, Sakai Y, Masuda K, Matsumura Y, Masuda K, Takase M (to be published) Nonsteroid anti-inflammatory drugs: basic studies on flurbiprofen eye drop. Jpn J Ophthalmol 25

    Google Scholar 

  • Kass MA, Neufeld AH, Sears ML (1975) Systemic aspirin and indomethacin do not prevent the response of the monkey eye to trauma. Invest Ophthalmol 14:604–606

    PubMed  CAS  Google Scholar 

  • Katz I (1981) Indomethacin. Ophthalmology 88:455–458

    PubMed  CAS  Google Scholar 

  • Kramer SG, Oyakawa RT, Drake M (1976) Enhancement of pupillary dilation during intraocular surgery by prostaglandin inhibition. Association for research in vision and ophthalmology meeting, 25-29 April 1976, Sarasota

    Google Scholar 

  • Kulkarni PS, Bhattacherjee P, Eakins, KE, Srinivasan BD (1981) Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. Curr Eye Res 1:43

    Article  PubMed  CAS  Google Scholar 

  • Lee RE (1974) The influence of psychotropic drugs on prostaglandin biosynthesis. Prostaglandins 5:63

    Article  PubMed  CAS  Google Scholar 

  • Leopold IH, Murray D (1979) Noncorticosteroidal anti-inflammatory agents in ophthalmology. Ophthalmology 86:142–155

    PubMed  CAS  Google Scholar 

  • Martin NF, Green WR, Martin LW (1977) Retinal phlebitis in the Irvine-Gass syndrome. Am J Ophthalmol 83:377–386

    PubMed  CAS  Google Scholar 

  • Masuda K, Izawa Y, Mishima S (1977) Breakdown of the blood-aqueous barrier and prostaglandins. Bibl Anat 16:99

    PubMed  CAS  Google Scholar 

  • McGill JI, Easty DL, Levuy I, Holt-Wilson AD, Shilling J (1971) The etiology and treatment of marginal corneal ulcers. Trans Ophthalmol Soc UK 91:501

    PubMed  CAS  Google Scholar 

  • Miami Study Group (1979) Cystoid macular edema in aphakic and pseudophakic eyes. Am J Ophthalmol 88:45–48

    Google Scholar 

  • Miller JD, Eakins KE, Atwal M (1973) The release of PGE2-like activity into aqueous humor after paracentesis and its prevention by aspirin. Invest Ophthalmol 12:939

    PubMed  CAS  Google Scholar 

  • Mishima S, Masuda K (1977) Clinical implication of prostaglandins and synthesis inhibitors. In: Burns RP, Leopold IH (eds) Symposium on ocular therapy, vol 10. Wiley, New York, pp 1–19

    Google Scholar 

  • Mishima S, Masuda K (1979) Prostaglandins and the eye: a review on clinical implications. Metab Pediatr Ophthalmol 3:179

    CAS  Google Scholar 

  • Mishima S, Masuda K, Tamura T (1977) The drugs influencing the intraocular pressure. In: Dikstein S (ed) Drugs and ocular tissues. Karger, Basel, p 128

    Google Scholar 

  • Miyake K (1977) Prevention of cystoid macular edema after lens extraction by topical indomethacin: a preliminary report. Albrecht von Graefes Arch Klin Exp Ophthalmol 203:81–88

    Article  PubMed  CAS  Google Scholar 

  • Miyake K (1978) Prophylaxis of aphakic cystoid macular edema using topical indomethacin. Am Intra-Ocular Implant Soc J 4:174

    CAS  Google Scholar 

  • Miyake K, Sugiyama S, Norimatsu I, Ozawa T (1978) Prevention of macular cystoid macular edema after lens extraction by topical indomethacin (III) radio-immunoassay measurement of prostaglandins in the aqueous during and after lens extraction procedure. Albrecht von Graefes Arch Ophthalmol 209:83

    Article  CAS  Google Scholar 

  • Mochizuki M (1980) Transport of indomethacin in the anterior uvea of the albino rabbit. Jpn J Ophthalmol 24:363

    CAS  Google Scholar 

  • Mochizuki M, Sawa M, Masuda K (1977) Topical indomethacin in intracapsular extraction of senile cataract. Jpn J Ophthalmol 21:215

    Google Scholar 

  • Mortada A, Abboud I (1973) Retinal haemorrhages after prolonged use of salicylates. Brit J Ophthalmol 57:199–200

    Article  CAS  Google Scholar 

  • Neufeld AH, Jampol LM, Sears ML (1972) Aspirin prevents the disruption of the bloodaqueous barrier in the rabbit eye. Nature 238:158–159

    Article  PubMed  CAS  Google Scholar 

  • Norru MS (1973) Oxyphenbutazone (Tandearil R) as an adjuvant in treatment of dendritic keratitis, double blind trial using fluorescein-rose Bengal vital staining. Acta Ophthalmol 51:591

    Google Scholar 

  • Nozu K (1978) Flurbiprofen: highly potent inhibitor of prostaglandin synthesis. Biochimica Biophysica Acta 529:493

    CAS  Google Scholar 

  • Palimeris G, Koliopoulos J, Velissaropoulos P (1972) Ocular side effects of indomethacin. Ophthalmologica 164:339

    Article  PubMed  CAS  Google Scholar 

  • Perkins ES (1975) Prostaglandins and the eye. Adv Ophthalmol 29:2

    PubMed  CAS  Google Scholar 

  • Podos SM, Becker B (1976) Comparison of ocular prostaglandin synthesis inhibitors. Invest Ophthalmol 15:841–844

    PubMed  CAS  Google Scholar 

  • Podos SM, Sugar A (1980) The use of nonsteroidal anti-inflammatory drugs in ocular conditions. In: Srinivasan BD (ed) Ocular therapeutics. Masson, New York, Chap 9, pp 73–81

    Google Scholar 

  • Podos SM, Becker B, Kass MA (1973) Indomethacin blocks arachidonic acid-induced elevation of intraocular pressure. Prostaglandins 3:7–15

    Article  PubMed  CAS  Google Scholar 

  • Rabey JM, et al. (1977) Ophthalmoplegic migraine: amelioration by flufenamic acid, a prostaglandin inhibitor. Ophthalmologica 175:158

    Article  Google Scholar 

  • Sawa M, Masuda K (1976) Topical indomethacin in soft cataract aspiration. Jpn J Ophthalmol 20:514

    Google Scholar 

  • Sears ML (1974) The use of aspirin and aspirin-like drugs in ophthalmology. In: Leopold IH (ed) Symposium on ocular therapy, vol 7. Mosby, St. Louis, Chap 10, pp 104–115

    Google Scholar 

  • Sears ML, Neufeld AH, Jampol LM (1973) Prostaglandins. Invest Ophthalmol 12:161–164

    PubMed  CAS  Google Scholar 

  • Sears D, Sears M (1974) Blood-aqueous barrier and alpha chymotrypsin glaucoma in rabbits. Am J Ophthalmol 77:378–383

    PubMed  CAS  Google Scholar 

  • Soloway HR, Stjernschantz J, Sears ML (1981) The miotic effect of substance P on the isolated rabbit iris. Invest Ophthalmol Vis Sci 20:47–52

    PubMed  CAS  Google Scholar 

  • Stjernschantz J, Sears M, Stjernschantz L (1981) Intraocular effects of substance P in the rabbit. Invest Ophthalmol Vis Sci 20:53–60

    PubMed  CAS  Google Scholar 

  • Stone E (1763) An account of the success of the bark of the willow in the cure of agues. Philos Trans R Soc Lond 53:195

    Article  Google Scholar 

  • Sukamoto H (1976) Clinical use of flurbiprofen as a postoperative anti-inflammatory agent. Folia Ophthalmol Jpn 27:87

    Google Scholar 

  • Tennant JL (1978) Prostaglandins in ophthalmology. In: Emery JM (ed) Current concepts in cataract surgery. Selected proceedings of the fifth biennial cataract congress. Mosby, St. Louis, pp 360–362

    Google Scholar 

  • Thomas AH, Hanna C (1973) Oxyphenbutazone in ocular inflammation. Arch Ophthalmol 89:340–341

    Article  PubMed  CAS  Google Scholar 

  • Unger WG, Cole DF, Hammond B (1975) Disruption of the blood-aqueous barrier following paracentesis in the rabbit. Exp Eye Res 20:255–270

    Article  PubMed  CAS  Google Scholar 

  • Vane JR (1971) Inhibition of prostaglandin-synthesis as a mechanism of action for aspirin-like drugs. Nature [New Biol] 231:232

    CAS  Google Scholar 

  • Vane JR (1976) The mode of action of aspirin and similar compounds. J Allergy Clin Immun 58:691

    Article  PubMed  CAS  Google Scholar 

  • Watson PG, Hayreh SS, Awdry PN (1968) Episcleritis and scleritis. Br J Ophthalmol 52:348–349

    Article  PubMed  CAS  Google Scholar 

  • Watson PG, MacKay DAR, Clement RS, Wilkinson P (1973) Treatment of episcleritis, a double blind trial comparing betamethasone 0.1 percent, oxyphenbutazone 10 percent and placebo eye ointments. Br J Ophthal 57:866–870

    Article  CAS  Google Scholar 

  • Williamson J, Sim AK, Chawla JC, Tham HM, Forrester JV, Mammo NV (1976) Estimation of oxyphenbutazone concentrations in human serum and aqueous humor. Eye Ear Nose Throat Mon 55:176

    PubMed  CAS  Google Scholar 

  • Woods AC (1961) Endogenous inflammation of the uveal tract. Williams and Wilkins, Baltimore, p 458

    Google Scholar 

  • Yannuzzzi LA, Klein RM, Wallyn RH, Cohen N, Katz I (1977) ineffectiveness of indomethacin in the treatment of chronic cystoid macular edema. Am J Ophthalmol 84:517-519

    Google Scholar 

  • Zimmerman TJ, Gravenstein N, Sugar A, Kaufman HE (1975) Aspirin stabilization of the blood-aqueous barier in the human eye. Am J Ophthalmol 79:817–819

    PubMed  CAS  Google Scholar 

  • Zimmerman TJ, Binder P, Abel RA, Kaufman H (1976) Asprin and the intraocular pressure rise following aphakic penetrating keratoplasty: a negetive report. Ann Ophthalmol 8:611–s613

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. K. Masuda
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Ophthalmology and Visual Science, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT, 06510, USA

    Marvin L. Sears

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Masuda, K. (1984). Anti-Inflammatory Agents: Nonsteroidal Anti-Inflammatory Drugs. In: Sears, M.L. (eds) Pharmacology of the Eye. Handbook of Experimental Pharmacology, vol 69. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69222-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69222-2_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69224-6

  • Online ISBN: 978-3-642-69222-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation